SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 214
ALA A 208
LEU A 206
THR A 104
 None
 1.10A 2roxB-4xfdA:
undetectable		 2roxB-4xfdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A  24
ILE A  28
LEU A  58
GLY A 207
ALA A 208
 None
 1.20A 2xf3B-4xfdA:
undetectable		 2xf3B-4xfdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  24
LEU A  58
GLY A 207
ALA A 208
 None
 0.83A 2xfsA-4xfdA:
undetectable		 2xfsA-4xfdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A  24
ILE A  28
LEU A  58
GLY A 207
ALA A 208
 None
 1.23A 2xfsB-4xfdA:
undetectable		 2xfsB-4xfdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  24
LEU A  58
GLY A 207
ALA A 208
 None
 0.85A 2xh9A-4xfdA:
undetectable		 2xh9A-4xfdA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  83
ALA A 155
VAL A 113
VAL A  85
GLY A  50
 None
 0.91A 3kw4A-4xfdA:
undetectable		 3kw4A-4xfdA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.05A 4feuB-4xfdA:
undetectable		 4feuB-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.03A 4feuD-4xfdA:
undetectable		 4feuD-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.02A 4feuF-4xfdA:
undetectable		 4feuF-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.06A 4fevB-4xfdA:
undetectable		 4fevB-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.08A 4fevD-4xfdA:
undetectable		 4fevD-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.07A 4fevF-4xfdA:
undetectable		 4fevF-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.05A 4fewB-4xfdA:
undetectable		 4fewB-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.09A 4fewD-4xfdA:
undetectable		 4fewD-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.08A 4fewF-4xfdA:
undetectable		 4fewF-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.10A 4fexB-4xfdA:
undetectable		 4fexB-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.09A 4gkhB-4xfdA:
undetectable		 4gkhB-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.05A 4gkhD-4xfdA:
undetectable		 4gkhD-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.10A 4gkhF-4xfdA:
undetectable		 4gkhF-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.09A 4gkhG-4xfdA:
undetectable		 4gkhG-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.06A 4gkhJ-4xfdA:
undetectable		 4gkhJ-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.06A 4gkhC-4xfdA:
undetectable
4gkhK-4xfdA:
undetectable		 4gkhC-4xfdA:
21.36
4gkhK-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.10A 4gkiA-4xfdA:
undetectable		 4gkiA-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.08A 4gkiC-4xfdA:
undetectable		 4gkiC-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  56
ASP A 168
ASP A 242
GLU A 172
 None
 1.08A 4gkiE-4xfdA:
undetectable
4gkiG-4xfdA:
undetectable		 4gkiE-4xfdA:
21.36
4gkiG-4xfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 155
VAL A 151
GLY A 162
THR A  46
PHE A  82
 None
 1.15A 5igiA-4xfdA:
undetectable		 5igiA-4xfdA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  56
ALA A  84
ILE A  51
GLY A 166
GLY A  61
 None
 1.26A 6awoA-4xfdA:
1.3		 6awoA-4xfdA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xfd NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  56
ALA A  84
ILE A  51
GLY A 166
GLY A  61
 None
 1.27A 6awqA-4xfdA:
1.3		 6awqA-4xfdA:
19.65