SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		3 / 3 GLU A  31
ILE A  32
ARG A 149
 None
BDP  A 401 ( 4.5A)
BDP  A 401 (-2.9A)
 0.67A 1cd2A-4xfeA:
undetectable		 1cd2A-4xfeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		3 / 3 MET A 265
ASN A 326
GLN A 330
 None
 0.78A 1xoqB-4xfeA:
undetectable		 1xoqB-4xfeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		5 / 12 LEU A 315
MET A 316
ILE A 319
GLY A 309
LEU A 175
 None
 1.02A 2lbdA-4xfeA:
undetectable		 2lbdA-4xfeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		4 / 8 MET A 180
LEU A 163
PRO A 106
GLY A 230
 None
 0.79A 2qd5A-4xfeA:
undetectable		 2qd5A-4xfeA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		4 / 8 ILE A  92
GLU A 208
LEU A 232
GLY A  94
 None
 0.93A 2qqdB-4xfeA:
undetectable
2qqdC-4xfeA:
undetectable		 2qqdB-4xfeA:
15.50
2qqdC-4xfeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		4 / 8 VAL A 170
ARG A 149
VAL A 304
TYR A 308
 None
BDP  A 401 (-2.9A)
None
None
 1.33A 2y05A-4xfeA:
undetectable
2y05B-4xfeA:
undetectable		 2y05A-4xfeA:
22.75
2y05B-4xfeA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		4 / 7 MET A 180
LEU A 163
PRO A 106
GLY A 230
 None
 1.11A 3hcnA-4xfeA:
undetectable		 3hcnA-4xfeA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		5 / 11 ASN A 133
GLY A 124
ILE A 119
VAL A  93
ILE A 131
 None
 1.02A 3lzvB-4xfeA:
undetectable		 3lzvB-4xfeA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		5 / 11 VAL A 100
GLY A 124
GLY A 121
TYR A 328
ILE A 118
 None
None
None
CXS  A 402 (-3.0A)
None
 1.38A 3owxA-4xfeA:
undetectable
3owxB-4xfeA:
undetectable		 3owxA-4xfeA:
21.02
3owxB-4xfeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		4 / 5 GLU A 236
LEU A  90
GLN A 171
GLY A  91
 BDP  A 401 (-3.0A)
None
BDP  A 401 (-3.7A)
None
 1.14A 3pp1A-4xfeA:
undetectable		 3pp1A-4xfeA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		5 / 12 VAL A 100
PRO A 237
ILE A 319
VAL A 108
ILE A 233
 None
 1.28A 4eb6B-4xfeA:
undetectable
4eb6C-4xfeA:
undetectable		 4eb6B-4xfeA:
20.73
4eb6C-4xfeA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F92_B_SANB2201_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		5 / 9 GLU A  71
ASN A 173
GLN A 171
GLY A  91
SER A  89
 BDP  A 401 (-2.8A)
None
BDP  A 401 (-3.7A)
None
BDP  A 401 (-4.9A)
 1.47A 4f92B-4xfeA:
0.0		 4f92B-4xfeA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		5 / 9 ALA A 182
ILE A 177
GLY A 187
ILE A 168
VAL A 304
 None
 0.91A 4nptA-4xfeA:
undetectable		 4nptA-4xfeA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		3 / 3 GLU A  71
THR A 213
HIS A  33
 BDP  A 401 (-2.8A)
BDP  A 401 (-3.9A)
BDP  A 401 (-4.0A)
 0.83A 4ydqB-4xfeA:
2.3		 4ydqB-4xfeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		4 / 7 LEU A 175
PHE A 176
ILE A 188
ASN A 181
 None
 1.06A 5n5dA-4xfeA:
undetectable		 5n5dA-4xfeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		3 / 3 MET A 105
GLU A 306
ARG A 305
 None
 0.99A 5tjyA-4xfeA:
3.0		 5tjyA-4xfeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		3 / 3 MET A 105
GLU A 306
ARG A 305
 None
 0.95A 5tjzA-4xfeA:
undetectable		 5tjzA-4xfeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP
(Pseudomonas
putida) 		3 / 3 VAL A  83
ALA A  30
GLN A  77
 None
 0.47A 6gb9A-4xfeA:
undetectable		 6gb9A-4xfeA:
21.15