SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLY A 225
THR A 291
HIS A 334
SER A 355
 None
 0.76A 1c9sT-4xfjA:
undetectable
1c9sU-4xfjA:
undetectable		 1c9sT-4xfjA:
8.68
1c9sU-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLY A 225
THR A 291
HIS A 334
SER A 355
 None
 0.76A 1gtfL-4xfjA:
undetectable
1gtfM-4xfjA:
undetectable		 1gtfL-4xfjA:
8.68
1gtfM-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLY A 225
THR A 291
HIS A 334
SER A 355
 None
 0.75A 1gtfN-4xfjA:
undetectable
1gtfO-4xfjA:
undetectable		 1gtfN-4xfjA:
8.68
1gtfO-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 TYR A 272
ASN A 123
TYR A  87
TYR A 312
 None
ARG  A 503 (-3.9A)
None
ARG  A 503 ( 4.5A)
 1.38A 1kiaA-4xfjA:
undetectable		 1kiaA-4xfjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 TYR A 272
ASN A 123
TYR A  87
TYR A 312
 None
ARG  A 503 (-3.9A)
None
ARG  A 503 ( 4.5A)
 1.37A 1kiaB-4xfjA:
undetectable		 1kiaB-4xfjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TYR A 272
ASN A 123
TYR A  87
TYR A 312
 None
ARG  A 503 (-3.9A)
None
ARG  A 503 ( 4.5A)
 1.37A 1kiaC-4xfjA:
undetectable		 1kiaC-4xfjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TYR A 272
ASN A 123
TYR A  87
TYR A 312
 None
ARG  A 503 (-3.9A)
None
ARG  A 503 ( 4.5A)
 1.37A 1kiaD-4xfjA:
2.4		 1kiaD-4xfjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 TYR A 272
ASN A 123
TYR A  87
TYR A 312
 None
ARG  A 503 (-3.9A)
None
ARG  A 503 ( 4.5A)
 1.38A 1nbhA-4xfjA:
undetectable		 1nbhA-4xfjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TYR A 272
ASN A 123
TYR A  87
TYR A 312
 None
ARG  A 503 (-3.9A)
None
ARG  A 503 ( 4.5A)
 1.38A 1nbhB-4xfjA:
undetectable		 1nbhB-4xfjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 TYR A 272
ASN A 123
TYR A  87
TYR A 312
 None
ARG  A 503 (-3.9A)
None
ARG  A 503 ( 4.5A)
 1.38A 1nbhC-4xfjA:
undetectable		 1nbhC-4xfjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TYR A 272
ASN A 123
TYR A  87
TYR A 312
 None
ARG  A 503 (-3.9A)
None
ARG  A 503 ( 4.5A)
 1.38A 1nbhD-4xfjA:
undetectable		 1nbhD-4xfjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLY A 225
THR A 291
HIS A 334
SER A 355
 None
 0.77A 1utdI-4xfjA:
undetectable
1utdJ-4xfjA:
undetectable		 1utdI-4xfjA:
8.68
1utdJ-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 THR A  26
ILE A  22
GLY A  23
PHE A 158
PRO A 144
 None
 1.30A 2y7pA-4xfjA:
undetectable		 2y7pA-4xfjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 SER A 268
LEU A 263
GLY A 122
GLU A 260
 None
None
None
ARG  A 503 (-3.1A)
 0.89A 3aiaA-4xfjA:
undetectable
3aiaB-4xfjA:
undetectable		 3aiaA-4xfjA:
20.36
3aiaB-4xfjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 THR A 331
HIS A 284
ASN A  80
PHE A 327
 None
 1.23A 4awuA-4xfjA:
undetectable		 4awuA-4xfjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 ASP A 207
GLY A 346
PRO A 215
THR A 214
 None
 1.03A 4l1aB-4xfjA:
undetectable		 4l1aB-4xfjA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 12 ALA A 240
VAL A 220
GLY A 276
ILE A 230
GLY A 248
VAL A 180
 None
 0.88A 4q5mA-4xfjA:
undetectable		 4q5mA-4xfjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLU A 260
TYR A  87
ASP A 177
ALA A 184
 ARG  A 503 (-3.1A)
None
ANP  A 501 (-4.6A)
ARG  A 503 ( 3.9A)
 0.97A 4zz8A-4xfjA:
undetectable		 4zz8A-4xfjA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 SER A 355
GLY A 225
THR A 291
HIS A 334
 None
 0.75A 5eezL-4xfjA:
undetectable
5eezV-4xfjA:
undetectable		 5eezL-4xfjA:
8.68
5eezV-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 SER A 355
GLY A 225
THR A 291
HIS A 334
 None
 0.75A 5ef1L-4xfjA:
undetectable
5ef1V-4xfjA:
undetectable		 5ef1L-4xfjA:
8.68
5ef1V-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 SER A 355
GLY A 225
THR A 291
HIS A 334
 None
 0.75A 5ef2L-4xfjA:
undetectable
5ef2V-4xfjA:
undetectable		 5ef2L-4xfjA:
8.68
5ef2V-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4xfj ARGININOSUCCINATE
SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LYS A 267
VAL A 259
ASP A 261
 None
 0.35A 6fgdA-4xfjA:
2.3		 6fgdA-4xfjA:
24.00