SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 11 ILE A 280
ALA A 283
VAL A 285
ARG A 230
ALA A 314
 None
 1.11A 1n4hA-4xfkA:
undetectable		 1n4hA-4xfkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 11 ILE A 280
VAL A 285
ARG A 230
VAL A 248
ALA A 314
 None
 1.08A 1n4hA-4xfkA:
undetectable		 1n4hA-4xfkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 4 THR A 315
GLY A 322
ASP A 440
ALA A 327
 None
 1.17A 1sg9A-4xfkA:
5.0		 1sg9A-4xfkA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 PHE A 204
ASN A 186
GLU A 190
GLY A 188
 None
None
None
NA  A 502 (-3.6A)
 0.95A 1ykiA-4xfkA:
undetectable
1ykiB-4xfkA:
undetectable		 1ykiA-4xfkA:
21.23
1ykiB-4xfkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 TYR A 238
PHE A 317
GLY A 188
ALA A 189
LEU A 194
 ACT  A 500 (-4.4A)
ACT  A 500 ( 4.9A)
NA  A 502 (-3.6A)
ACT  A 500 (-4.2A)
None
 0.85A 2aylA-4xfkA:
undetectable		 2aylA-4xfkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 6 TYR A 238
PRO A 136
ILE A 166
LEU A 194
 ACT  A 500 (-4.4A)
None
None
None
 1.12A 2wekB-4xfkA:
4.3		 2wekB-4xfkA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		3 / 3 VAL A 288
ASN A 235
TRP A 240
 None
None
ACT  A 500 ( 4.0A)
 0.84A 2y00B-4xfkA:
undetectable		 2y00B-4xfkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 GLN A 110
ALA A 117
PHE A 378
ASN A 115
GLY A 112
 None
 1.34A 3aobC-4xfkA:
undetectable		 3aobC-4xfkA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 TYR A 238
PHE A 317
GLY A 188
ALA A 189
LEU A 194
 ACT  A 500 (-4.4A)
ACT  A 500 ( 4.9A)
NA  A 502 (-3.6A)
ACT  A 500 (-4.2A)
None
 0.97A 3n8xA-4xfkA:
undetectable		 3n8xA-4xfkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 6 PRO A 321
GLY A 322
ASN A 326
LEU A 298
 None
 0.90A 3zqtA-4xfkA:
undetectable		 3zqtA-4xfkA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		3 / 3 LYS A  85
LEU A 128
ALA A 151
 None
 0.82A 4iizA-4xfkA:
undetectable		 4iizA-4xfkA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 6 ILE A 401
ILE A 153
PHE A 206
LEU A 375
 None
 0.92A 4m51A-4xfkA:
undetectable		 4m51A-4xfkA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 ALA A 311
ALA A 327
ILE A 330
ASN A 292
LEU A 300
 None
 1.18A 4r38A-4xfkA:
undetectable		 4r38A-4xfkA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 ALA A 311
ALA A 327
ILE A 330
ASN A 292
LEU A 300
 None
 1.22A 4r38D-4xfkA:
undetectable		 4r38D-4xfkA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 TRP A 240
PHE A 317
HIS A 203
THR A 195
 ACT  A 500 ( 4.0A)
ACT  A 500 ( 4.9A)
None
None
 1.44A 5yj1G-4xfkA:
undetectable
5yj1Y-4xfkA:
undetectable		 5yj1G-4xfkA:
16.08
5yj1Y-4xfkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 HIS A 203
THR A 195
TRP A 240
PHE A 317
 None
None
ACT  A 500 ( 4.0A)
ACT  A 500 ( 4.9A)
 1.46A 5yj1k-4xfkA:
undetectable
5yj1t-4xfkA:
undetectable		 5yj1k-4xfkA:
16.08
5yj1t-4xfkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		3 / 3 VAL A 359
TYR A 356
GLU A 116
 None
 0.79A 5zmqD-4xfkA:
undetectable
5zmqE-4xfkA:
undetectable		 5zmqD-4xfkA:
19.19
5zmqE-4xfkA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		3 / 3 ALA A 370
PHE A 424
GLN A 421
 None
 0.69A 6eceA-4xfkA:
2.7		 6eceA-4xfkA:
24.09