SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 TYR A 367
ASP A 305
VAL A 287
GLY A  27
 None
 1.19A 1ekjC-4xg1A:
undetectable
1ekjD-4xg1A:
undetectable		 1ekjC-4xg1A:
19.04
1ekjD-4xg1A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 ASP A 305
VAL A 287
GLY A  27
TYR A 367
 None
 1.19A 1ekjC-4xg1A:
undetectable
1ekjD-4xg1A:
undetectable		 1ekjC-4xg1A:
19.04
1ekjD-4xg1A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 GLU A  86
ILE A  38
TYR A  33
GLY A 284
 None
 1.11A 1maaB-4xg1A:
undetectable
1maaD-4xg1A:
undetectable		 1maaB-4xg1A:
21.88
1maaD-4xg1A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		6 / 9 HIS A 200
GLY A 202
SER A 203
ARG A 277
ARG A 313
TYR A 317
 LLP  A 508 (-3.5A)
None
LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-3.8A)
LLP  A 508 (-4.2A)
 0.73A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 SER A 203
ARG A 277
ARG A 313
TYR A 376
 LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-3.8A)
LLP  A 508 (-3.4A)
 0.77A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 SER A 203
ARG A 277
TYR A 317
TYR A 376
 LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-4.2A)
LLP  A 508 (-3.4A)
 0.32A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 ALA A 115
PHE A 123
ILE A 134
VAL A 137
 None
 0.97A 2cizA-4xg1A:
undetectable		 2cizA-4xg1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 11 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.45A 2iyfA-4xg1A:
undetectable		 2iyfA-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 THR A 258
GLU A 255
PHE A 211
ILE A 212
 None
 1.25A 2w98B-4xg1A:
undetectable		 2w98B-4xg1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 5 ILE A  56
TYR A 256
MET A 257
THR A 258
 None
 1.43A 3abkN-4xg1A:
undetectable
3abkW-4xg1A:
undetectable		 3abkN-4xg1A:
22.83
3abkW-4xg1A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 4 LEU A 311
ASP A 342
VAL A 304
THR A 288
 None
 1.07A 3cyxB-4xg1A:
undetectable		 3cyxB-4xg1A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 VAL A 395
VAL A  19
PHE A  13
GLU A  15
 None
 1.37A 3n61A-4xg1A:
undetectable
3n61B-4xg1A:
undetectable		 3n61A-4xg1A:
21.56
3n61B-4xg1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 12 ASP A  80
GLY A 238
SER A 103
LEU A 241
GLY A 276
 LLP  A 508 (-4.0A)
LLP  A 508 ( 4.7A)
LLP  A 508 (-3.5A)
None
LLP  A 508 (-3.2A)
 1.24A 4blvB-4xg1A:
undetectable		 4blvB-4xg1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 11 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.44A 4m83A-4xg1A:
undetectable		 4m83A-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 11 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.49A 4m83B-4xg1A:
undetectable		 4m83B-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		3 / 3 SER A 378
GLU A  86
GLU A 274
 None
None
LLP  A 508 (-3.8A)
 0.88A 4ymgB-4xg1A:
undetectable		 4ymgB-4xg1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 ILE A 134
VAL A 143
PRO A 146
ALA A 138
 None
 0.89A 5cu6A-4xg1A:
undetectable		 5cu6A-4xg1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 12 VAL A 369
VAL A 287
VAL A  68
THR A 379
GLY A 377
 None
 1.20A 6brdC-4xg1A:
undetectable		 6brdC-4xg1A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 12 ASP A 247
GLU A 248
GLN A 204
LEU A 311
ILE A 323
 None
 1.46A 6fzbB-4xg1A:
undetectable		 6fzbB-4xg1A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 9 ILE A 347
ALA A 307
GLY A 377
TYR A  31
ASN A 309
 None
 1.21A 6nm4B-4xg1A:
undetectable		 6nm4B-4xg1A:
18.76