SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xga'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 TRP B 206
VAL B 208
TRP B 205
 None
 1.34A 1c4dC-4xgaB:
undetectable
1c4dD-4xgaB:
undetectable		 1c4dC-4xgaB:
5.08
1c4dD-4xgaB:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 7 VAL B 258
LEU B 226
SER B 228
LEU B 231
 None
 0.83A 1j8uA-4xgaB:
undetectable		 1j8uA-4xgaB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 VAL B 258
LEU B 226
SER B 228
LEU B 231
THR B 243
 None
 0.94A 1kw0A-4xgaB:
undetectable		 1kw0A-4xgaB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 11 VAL B 258
LEU B 226
SER B 228
LEU B 231
THR B 243
 None
 1.02A 1mmtA-4xgaB:
undetectable		 1mmtA-4xgaB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 HIS B 280
GLU B 285
ILE B 284
GLY B 275
VAL B 322
 None
 1.24A 4fqsA-4xgaB:
undetectable		 4fqsA-4xgaB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 HIS B 280
GLU B 285
ILE B 284
GLY B 275
VAL B 322
 None
 1.25A 4fqsB-4xgaB:
undetectable		 4fqsB-4xgaB:
21.21