SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 10 GLY A 144
PHE A 254
LEU A 176
THR A 394
LEU A 173
 None
 1.40A 1a8uA-4xghA:
undetectable		 1a8uA-4xghA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 10 GLY A 144
PHE A 254
LEU A 176
THR A 394
LEU A 173
 None
 1.41A 1a8uB-4xghA:
undetectable		 1a8uB-4xghA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 334
LEU A 336
ALA A 223
PHE A 385
HIS A 231
 None
None
None
None
EDO  A 509 ( 3.2A)
 1.19A 3b0wA-4xghA:
undetectable		 3b0wA-4xghA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		4 / 8 LEU A 230
ALA A  82
TYR A  73
SER A  90
 None
 0.97A 3rodA-4xghA:
undetectable		 3rodA-4xghA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 11 MET A 136
LEU A 139
ALA A 141
LEU A 146
GLY A 260
 None
 1.19A 3uudA-4xghA:
undetectable		 3uudA-4xghA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		3 / 3 ASN A 273
SER A 371
ARG A 319
 EDO  A 509 (-3.4A)
None
SO4  A 502 (-3.1A)
 0.90A 5b2qA-4xghA:
undetectable		 5b2qA-4xghA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		4 / 5 LEU A  99
TYR A  76
CYH A  91
ASP A 225
 None
 1.36A 5p9iA-4xghA:
undetectable		 5p9iA-4xghA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 PHE A 126
ALA A 180
LEU A 173
PHE A 129
LEU A 146
 None
 1.38A 5uanB-4xghA:
undetectable		 5uanB-4xghA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 137
GLY A 266
ASP A 132
ALA A 133
ARG A 130
 SO4  A 505 ( 4.8A)
None
None
None
None
 1.32A 5zvgA-4xghA:
undetectable		 5zvgA-4xghA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 137
GLY A 266
ASP A 132
ALA A 133
ARG A 130
 SO4  A 505 ( 4.8A)
None
None
None
None
 1.35A 5zvgB-4xghA:
undetectable		 5zvgB-4xghA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 138
GLY A 144
ALA A 141
ALA A 258
ALA A 259
 None
 0.92A 5zw4A-4xghA:
undetectable		 5zw4A-4xghA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 9 TYR A 183
ALA A 137
PHE A 125
GLY A 128
PHE A 129
 None
SO4  A 505 ( 4.8A)
None
None
None
 1.34A 6awoA-4xghA:
undetectable		 6awoA-4xghA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xgh CITRATE SYNTHASE
(Burkholderia
thailandensis) 		5 / 9 TYR A 183
ALA A 137
PHE A 125
GLY A 128
PHE A 129
 None
SO4  A 505 ( 4.8A)
None
None
None
 1.34A 6awqA-4xghA:
undetectable		 6awqA-4xghA:
21.98