SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A  77
THR A 167
VAL A  91
 None
 0.87A 1hxbA-4xgiA:
undetectable		 1hxbA-4xgiA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 LEU A  30
VAL A  33
ALA A 419
CYH A 420
 None
 0.99A 1mz9D-4xgiA:
undetectable		 1mz9D-4xgiA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ALA A 359
VAL A 357
TRP A 108
 None
 0.58A 1tkqB-4xgiA:
undetectable		 1tkqB-4xgiA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ARG A 145
GLY A 126
ILE A 154
ILE A 171
ILE A 150
 None
 0.77A 2b60A-4xgiA:
undetectable		 2b60A-4xgiA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 ASP A 159
PRO A 161
THR A 192
TRP A 371
 None
None
AKG  A 501 ( 4.9A)
None
 1.41A 2q6oB-4xgiA:
undetectable		 2q6oB-4xgiA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A  77
THR A 167
VAL A  91
 None
 0.91A 2qakA-4xgiA:
undetectable		 2qakA-4xgiA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 GLN A 259
THR A 283
HIS A 279
LEU A 276
 NAD  A 500 ( 4.9A)
None
None
None
 1.29A 2zj0A-4xgiA:
3.1		 2zj0A-4xgiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 GLN A 259
THR A 283
HIS A 279
LEU A 276
 NAD  A 500 ( 4.9A)
None
None
None
 1.30A 3ce6A-4xgiA:
undetectable		 3ce6A-4xgiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 GLN A 259
THR A 283
HIS A 279
LEU A 276
 NAD  A 500 ( 4.9A)
None
None
None
 1.30A 3ce6C-4xgiA:
undetectable		 3ce6C-4xgiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 THR A 273
VAL A 234
GLY A 209
THR A 208
 None
None
None
NAD  A 500 (-3.3A)
 1.05A 3cflA-4xgiA:
undetectable		 3cflA-4xgiA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8F_A_DM1A127_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 MET A 393
ALA A 396
VAL A 400
ALA A 419
VAL A 364
 None
None
None
None
AKG  A 501 ( 4.2A)
 1.16A 3f8fA-4xgiA:
undetectable
3f8fB-4xgiA:
0.8		 3f8fA-4xgiA:
12.96
3f8fB-4xgiA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 GLU A 138
GLU A  64
ALA A  71
ASN A  67
 None
 1.10A 3pgyA-4xgiA:
undetectable
3pgyB-4xgiA:
undetectable		 3pgyA-4xgiA:
23.96
3pgyB-4xgiA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 LEU A 389
GLY A 362
ILE A 243
VAL A 240
 None
None
None
NAD  A 500 (-4.0A)
 0.89A 3wriA-4xgiA:
undetectable		 3wriA-4xgiA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 LEU A 389
GLY A 362
ILE A 243
VAL A 240
 None
None
None
NAD  A 500 (-4.0A)
 0.90A 3wriB-4xgiA:
undetectable		 3wriB-4xgiA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 GLY A 238
ALA A 312
GLY A 236
VAL A 165
HIS A  94
 NAD  A 500 (-3.2A)
NAD  A 500 (-3.4A)
NAD  A 500 (-3.3A)
NAD  A 500 (-3.5A)
None
 1.34A 4c5nB-4xgiA:
3.9		 4c5nB-4xgiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 ASP A  96
ASP A  22
GLU A  74
GLU A 101
 None
 1.16A 4fewB-4xgiA:
undetectable		 4fewB-4xgiA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 VAL A 409
SER A 410
THR A 413
 None
 0.42A 4luhA-4xgiA:
undetectable		 4luhA-4xgiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 ILE A 329
LYS A 328
ILE A 307
ALA A 230
 None
 0.95A 4ou1A-4xgiA:
undetectable		 4ou1A-4xgiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 TYR A 179
GLY A 155
PRO A 156
 None
 0.56A 4qwpA-4xgiA:
undetectable		 4qwpA-4xgiA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 SER A  83
ILE A 423
ALA A 114
ILE A 160
GLY A  89
 None
None
None
None
AKG  A 501 ( 3.9A)
 1.02A 5veuB-4xgiA:
undetectable		 5veuB-4xgiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ARG A 136
LEU A 139
GLY A 284
ILE A 171
GLY A 281
 None
 0.87A 5veuH-4xgiA:
undetectable		 5veuH-4xgiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 391
HIS A 387
ARG A 394
 None
 1.11A 6dwdD-4xgiA:
undetectable		 6dwdD-4xgiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4xgi GLUTAMATE
DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 GLY A  90
GLY A  89
VAL A 364
ASN A 113
GLY A 122
 AKG  A 501 (-3.2A)
AKG  A 501 ( 3.9A)
AKG  A 501 ( 4.2A)
None
None
 1.16A 6gneA-4xgiA:
2.7		 6gneA-4xgiA:
23.34