SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		5 / 6 HIS A  61
GLY A  59
TYR A  44
TYR A  58
GLU A  46
 FDA  A 403 (-3.7A)
FDA  A 403 ( 3.9A)
None
None
None
 1.41A 1dmaB-4xgkA:
undetectable		 1dmaB-4xgkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		3 / 3 ALA A  79
VAL A  74
TRP A  71
 None
 0.93A 1jo4A-4xgkA:
undetectable		 1jo4A-4xgkA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		3 / 3 ALA A  79
VAL A  74
TRP A  71
 None
 0.94A 1jo4B-4xgkA:
undetectable		 1jo4B-4xgkA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		3 / 3 ALA A  79
VAL A  74
TRP A  71
 None
 0.90A 1nruA-4xgkA:
undetectable		 1nruA-4xgkA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		3 / 3 ALA A  79
VAL A  74
TRP A  71
 None
 0.90A 1nruB-4xgkA:
undetectable		 1nruB-4xgkA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		3 / 3 GLY A  41
GLU A  34
ASN A  42
 FDA  A 403 (-3.2A)
FDA  A 403 (-2.7A)
FDA  A 403 (-4.0A)
 0.66A 1zq9A-4xgkA:
undetectable		 1zq9A-4xgkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		5 / 11 GLY A  12
SER A  11
LEU A  39
ILE A 371
ALA A 370
 FDA  A 403 (-3.3A)
None
None
None
FDA  A 403 (-3.5A)
 1.25A 2a58A-4xgkA:
6.5
2a58E-4xgkA:
6.4		 2a58A-4xgkA:
18.97
2a58E-4xgkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		5 / 11 ILE A  32
GLY A  41
HIS A  38
LEU A 217
GLY A  10
 None
FDA  A 403 (-3.2A)
None
None
FDA  A 403 (-3.1A)
 1.42A 2fn1A-4xgkA:
undetectable		 2fn1A-4xgkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 8 TYR A 326
HIS A  61
HIS A 290
ARG A 288
 40K  A 402 ( 3.9A)
FDA  A 403 (-3.7A)
None
40K  A 402 (-3.1A)
 1.29A 2vmyA-4xgkA:
undetectable
2vmyB-4xgkA:
undetectable		 2vmyA-4xgkA:
20.91
2vmyB-4xgkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 7 GLY A  12
ALA A 370
VAL A 238
ILE A  32
 FDA  A 403 (-3.3A)
FDA  A 403 (-3.5A)
None
None
 0.74A 3a2qA-4xgkA:
undetectable		 3a2qA-4xgkA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 5 ALA A 282
ALA A  89
TYR A  96
MET A 100
 None
 1.11A 3d91A-4xgkA:
undetectable		 3d91A-4xgkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		5 / 12 VAL A   9
GLY A  10
GLU A  34
LYS A  35
ASP A 220
 FDA  A 403 ( 4.8A)
FDA  A 403 (-3.1A)
FDA  A 403 (-2.7A)
None
FDA  A 403 (-3.7A)
 0.70A 3fuuA-4xgkA:
3.6		 3fuuA-4xgkA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		5 / 12 VAL A   9
GLY A  10
GLY A  12
LYS A  35
ASP A 220
 FDA  A 403 ( 4.8A)
FDA  A 403 (-3.1A)
FDA  A 403 (-3.3A)
None
FDA  A 403 (-3.7A)
 0.90A 3fuuA-4xgkA:
3.6		 3fuuA-4xgkA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		6 / 12 ARG A 358
GLY A  40
GLY A  12
LEU A  39
SER A 205
ALA A  43
 FDA  A 403 (-3.8A)
None
FDA  A 403 (-3.3A)
None
None
FDA  A 403 ( 4.5A)
 1.50A 3kkzA-4xgkA:
undetectable		 3kkzA-4xgkA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		5 / 12 ARG A 358
GLY A  40
GLY A  12
SER A 205
ALA A  43
 FDA  A 403 (-3.8A)
None
FDA  A 403 (-3.3A)
None
FDA  A 403 ( 4.5A)
 1.31A 3t7sD-4xgkA:
undetectable		 3t7sD-4xgkA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 5 HIS A  56
GLY A  59
TYR A  44
TYR A  58
 None
FDA  A 403 ( 3.9A)
None
None
 1.19A 4ae1B-4xgkA:
undetectable		 4ae1B-4xgkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 7 HIS A  56
TYR A 200
LEU A 195
PHE A 188
 None
 1.31A 4awuA-4xgkA:
undetectable		 4awuA-4xgkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 6 ASN A 206
MET A 367
ILE A 213
VAL A 215
 None
FDA  A 403 (-4.2A)
None
None
 0.70A 4olmA-4xgkA:
undetectable		 4olmA-4xgkA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 6 GLU A  54
PHE A 292
TYR A  83
HIS A 296
 None
 1.46A 4uciA-4xgkA:
undetectable		 4uciA-4xgkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 7 GLU A  54
PHE A 292
TYR A  83
HIS A 296
 None
 1.45A 4uciB-4xgkA:
undetectable		 4uciB-4xgkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 7 TYR A 325
ARG A 316
PHE A 261
GLU A 313
 FDA  A 403 (-4.2A)
None
None
None
 1.33A 4xzkA-4xgkA:
undetectable		 4xzkA-4xgkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		5 / 12 GLY A 360
TYR A 246
THR A 240
GLY A  10
PHE A 222
 None
None
FDA  A 403 ( 4.6A)
FDA  A 403 (-3.1A)
FDA  A 403 (-4.6A)
 1.00A 5d4uA-4xgkA:
2.7		 5d4uA-4xgkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		5 / 12 GLY A 360
TYR A 246
THR A 240
GLY A  10
PHE A 222
 None
None
FDA  A 403 ( 4.6A)
FDA  A 403 (-3.1A)
FDA  A 403 (-4.6A)
 0.98A 5d4uB-4xgkA:
undetectable		 5d4uB-4xgkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 7 GLY A  10
GLU A  34
LYS A  35
ASP A 220
 FDA  A 403 (-3.1A)
FDA  A 403 (-2.7A)
None
FDA  A 403 (-3.7A)
 0.51A 5mvsA-4xgkA:
undetectable		 5mvsA-4xgkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 8 GLY A  10
GLU A  34
LYS A  35
ASP A 220
 FDA  A 403 (-3.1A)
FDA  A 403 (-2.7A)
None
FDA  A 403 (-3.7A)
 0.43A 5mvsB-4xgkA:
undetectable		 5mvsB-4xgkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 6 GLY A  10
GLY A 241
PRO A 242
GLY A 360
 FDA  A 403 (-3.1A)
FDA  A 403 ( 3.7A)
FDA  A 403 (-4.7A)
None
 0.67A 6ag0C-4xgkA:
undetectable		 6ag0C-4xgkA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 5 TYR A 157
GLU A 313
TYR A  83
HIS A 290
 None
 1.20A 6ep4A-4xgkA:
undetectable		 6ep4A-4xgkA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4xgk UDP-GALACTOPYRANOSE
MUTASE
(Corynebacterium
diphtheriae) 		4 / 5 TYR A 326
GLU A 313
TYR A  83
HIS A 290
 40K  A 402 ( 3.9A)
None
None
None
 1.38A 6ep4A-4xgkA:
undetectable		 6ep4A-4xgkA:
14.96