SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZV_A_GCSA1900_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		4 / 6 GLU A 356
ASP A 546
TYR A 314
TRP A 576
 None
 1.45A 2vzvA-4xgmA:
0.5		 2vzvA-4xgmA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VZV_B_GCSB1900_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		4 / 6 GLU A 356
ASP A 546
TYR A 314
TRP A 576
 None
 1.47A 2vzvB-4xgmA:
1.2		 2vzvB-4xgmA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		5 / 11 ALA A 284
GLY A 289
ILE A 251
VAL A 260
ALA A 263
 None
 0.98A 3dcmX-4xgmA:
2.3		 3dcmX-4xgmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		5 / 12 ALA A 284
ILE A 251
MET A 278
LEU A 271
ILE A 304
 None
 1.17A 3qfxB-4xgmA:
undetectable		 3qfxB-4xgmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		4 / 8 PRO A 210
LEU A 216
ASN A 246
ILE A 236
 None
 0.89A 3u5kD-4xgmA:
undetectable		 3u5kD-4xgmA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		4 / 7 LEU A 233
PRO A 242
ILE A 275
LEU A 271
 None
 0.92A 5fxtA-4xgmA:
undetectable		 5fxtA-4xgmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		5 / 9 PRO A 277
TYR A 307
ILE A 304
THR A 281
ILE A 251
 None
 1.44A 5mvnB-4xgmA:
2.0		 5mvnB-4xgmA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_C_PFLC407_1
(PROTON-GATED ION
CHANNEL)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		5 / 9 PRO A 277
TYR A 307
ILE A 304
THR A 281
ILE A 251
 None
 1.43A 5mvnC-4xgmA:
2.0		 5mvnC-4xgmA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		5 / 10 PRO A 277
TYR A 307
ILE A 304
THR A 281
ILE A 251
 None
 1.44A 5mvnD-4xgmA:
2.0		 5mvnD-4xgmA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		3 / 3 LYS A 478
PRO A 480
LYS A 386
 None
 1.29A 5y9yA-4xgmA:
undetectable		 5y9yA-4xgmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens) 		3 / 3 TYR A 307
LEU A 279
ASP A 561
 None
 0.61A 5zv2B-4xgmA:
undetectable		 5zv2B-4xgmA:
13.33