SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 6 LEU A 162
ILE A 191
TYR A 221
VAL A 154
 None
 1.01A 1db1A-4xgoA:
undetectable		 1db1A-4xgoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		3 / 3 ASN A 170
ALA A 186
ASN A 210
 None
 0.83A 1n4fA-4xgoA:
undetectable		 1n4fA-4xgoA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 6 LEU A 175
TRP A 217
ASN A 210
LEU A 212
 None
 1.35A 1ru9H-4xgoA:
undetectable
1ru9L-4xgoA:
undetectable		 1ru9H-4xgoA:
21.55
1ru9L-4xgoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 5 LEU A 175
TRP A 217
ASN A 210
LEU A 212
 None
 1.42A 1ruaH-4xgoA:
undetectable
1ruaL-4xgoA:
undetectable		 1ruaH-4xgoA:
21.55
1ruaL-4xgoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 6 LEU A 175
TRP A 217
ASN A 210
LEU A 212
 None
 1.35A 1rukH-4xgoA:
undetectable
1rukL-4xgoA:
undetectable		 1rukH-4xgoA:
21.55
1rukL-4xgoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 5 LEU A 175
TRP A 217
ASN A 210
LEU A 212
 None
 1.39A 1rulH-4xgoA:
undetectable
1rulL-4xgoA:
undetectable		 1rulH-4xgoA:
21.55
1rulL-4xgoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		3 / 3 ASP A 300
PHE A 307
ASN A 279
 None
 0.87A 1sg9B-4xgoA:
undetectable		 1sg9B-4xgoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		5 / 11 VAL A 154
LEU A 151
LEU A 106
LEU A 127
MET A 120
 None
 1.09A 2a15A-4xgoA:
undetectable		 2a15A-4xgoA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		5 / 11 LEU A 274
ASN A 323
ILE A 237
VAL A 284
ILE A 304
 None
None
PO4  A1003 (-4.8A)
None
None
 1.13A 2uxoB-4xgoA:
undetectable		 2uxoB-4xgoA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 8 THR A 319
ASP A 300
SER A 277
TYR A 252
 None
 1.22A 2xz5A-4xgoA:
undetectable
2xz5C-4xgoA:
undetectable		 2xz5A-4xgoA:
19.83
2xz5C-4xgoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 8 THR A 319
ASP A 300
SER A 277
TYR A 252
 None
 1.20A 2xz5C-4xgoA:
undetectable
2xz5D-4xgoA:
undetectable		 2xz5C-4xgoA:
19.83
2xz5D-4xgoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 8 ASN A 232
ASN A 210
ILE A 177
VAL A 227
 None
 0.85A 2yoeB-4xgoA:
undetectable
2yoeC-4xgoA:
undetectable		 2yoeB-4xgoA:
17.86
2yoeC-4xgoA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 6 PHE A 242
THR A 215
LEU A 234
VAL A 253
 None
PO4  A1003 (-2.9A)
PO4  A1003 ( 4.7A)
None
 1.03A 2zuhA-4xgoA:
undetectable		 2zuhA-4xgoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 7 LEU A 156
ALA A 186
ASN A 189
ILE A 191
 None
 0.82A 4y03A-4xgoA:
undetectable		 4y03A-4xgoA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		3 / 3 HIS A 278
ASP A 300
HIS A 301
 None
 0.94A 5n1tW-4xgoA:
undetectable		 5n1tW-4xgoA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B
(Anopheles
gambiae) 		4 / 6 MET A 119
THR A 118
LEU A 141
MET A  97
 None
 1.07A 6mvxA-4xgoA:
undetectable
6mvxB-4xgoA:
undetectable
6mvxC-4xgoA:
undetectable		 6mvxA-4xgoA:
20.63
6mvxB-4xgoA:
20.63
6mvxC-4xgoA:
20.63