SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 10 VAL A1009
VAL A 920
ASN A 959
ILE A 927
LEU A 951
 None
 1.19A 1fe2A-4xgtA:
0.2		 1fe2A-4xgtA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 ARG A1095
SER A1092
SER A1100
ASN A1102
 None
 1.12A 1hwiB-4xgtA:
undetectable		 1hwiB-4xgtA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 ARG A1095
SER A1092
SER A1100
ASN A1102
 None
 1.07A 1hwkA-4xgtA:
undetectable		 1hwkA-4xgtA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 ARG A1095
SER A1092
SER A1100
ASN A1102
 None
 1.05A 1hwkC-4xgtA:
undetectable		 1hwkC-4xgtA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 ARG A1095
SER A1092
SER A1100
ASN A1102
 None
 1.04A 1hwkD-4xgtA:
undetectable		 1hwkD-4xgtA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 11 GLY A 365
ALA A 364
ASP A 594
ILE A 369
ILE A 391
 None
 0.84A 1ohrA-4xgtA:
undetectable		 1ohrA-4xgtA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 840
ILE A 839
ILE A 829
PRO A 838
 None
 0.96A 1oniB-4xgtA:
undetectable
1oniC-4xgtA:
undetectable		 1oniB-4xgtA:
8.98
1oniC-4xgtA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 LEU A1064
LEU A1057
ILE A 983
THR A 985
ILE A 973
 None
 1.22A 1tw4B-4xgtA:
undetectable		 1tw4B-4xgtA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.94A 1v54P-4xgtA:
undetectable
1v54W-4xgtA:
undetectable		 1v54P-4xgtA:
12.69
1v54W-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.94A 1v55C-4xgtA:
undetectable
1v55J-4xgtA:
undetectable		 1v55C-4xgtA:
12.69
1v55J-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 ALA A 481
LEU A 502
ILE A 498
ILE A 495
LEU A 524
 None
 0.92A 1xdkF-4xgtA:
undetectable		 1xdkF-4xgtA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 9 LEU A 956
PHE A 961
LEU A 952
LEU A1026
ALA A1001
 None
 1.14A 2bxeA-4xgtA:
undetectable		 2bxeA-4xgtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.87A 2dysP-4xgtA:
undetectable
2dysW-4xgtA:
undetectable		 2dysP-4xgtA:
12.69
2dysW-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.93A 2eijC-4xgtA:
undetectable
2eijJ-4xgtA:
undetectable		 2eijC-4xgtA:
12.69
2eijJ-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.98A 2eikC-4xgtA:
undetectable
2eikJ-4xgtA:
undetectable		 2eikC-4xgtA:
12.69
2eikJ-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.92A 2eimC-4xgtA:
undetectable
2eimJ-4xgtA:
undetectable		 2eimC-4xgtA:
12.69
2eimJ-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.97A 2einC-4xgtA:
undetectable
2einJ-4xgtA:
undetectable		 2einC-4xgtA:
12.69
2einJ-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 1.05A 2einP-4xgtA:
undetectable
2einW-4xgtA:
undetectable		 2einP-4xgtA:
12.69
2einW-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 10 GLY A 365
ALA A 364
ASP A 594
ILE A 369
ILE A 391
 None
 0.93A 2r5qD-4xgtA:
undetectable		 2r5qD-4xgtA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 TYR A 571
SER A 568
LEU A 597
THR A 326
 None
 1.19A 2v0zO-4xgtA:
undetectable		 2v0zO-4xgtA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 PRO A 163
GLU A 160
TYR A 161
 None
 0.76A 2zmbA-4xgtA:
undetectable		 2zmbA-4xgtA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 1.01A 2zxwP-4xgtA:
undetectable
2zxwW-4xgtA:
undetectable		 2zxwP-4xgtA:
12.69
2zxwW-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.86A 3ag1C-4xgtA:
undetectable
3ag1J-4xgtA:
undetectable		 3ag1C-4xgtA:
12.69
3ag1J-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.95A 3ag2C-4xgtA:
undetectable		 3ag2C-4xgtA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.91A 3ag2P-4xgtA:
undetectable
3ag2W-4xgtA:
undetectable		 3ag2P-4xgtA:
12.69
3ag2W-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.93A 3ag4C-4xgtA:
undetectable
3ag4J-4xgtA:
undetectable		 3ag4C-4xgtA:
12.69
3ag4J-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.96A 3ag4P-4xgtA:
undetectable
3ag4W-4xgtA:
undetectable		 3ag4P-4xgtA:
12.69
3ag4W-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.97A 3asnC-4xgtA:
undetectable
3asnJ-4xgtA:
undetectable		 3asnC-4xgtA:
12.69
3asnJ-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 GLY A 365
ALA A 364
ASP A 594
ILE A 369
ILE A 391
 None
 0.87A 3d1yA-4xgtA:
undetectable		 3d1yA-4xgtA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 GLU A1054
VAL A1052
CYH A1047
 None
 1.09A 3fbxA-4xgtA:
undetectable		 3fbxA-4xgtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 5 LEU A 687
LYS A 859
LEU A 863
GLU A 864
 None
 1.12A 3h5gA-4xgtA:
undetectable
3h5gB-4xgtA:
undetectable		 3h5gA-4xgtA:
3.21
3h5gB-4xgtA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 LEU A 753
ARG A 735
PRO A 719
GLY A 771
 None
 1.09A 3hcrA-4xgtA:
3.5		 3hcrA-4xgtA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 TYR A 360
GLU A 375
LEU A 370
ASN A 383
 None
 1.30A 3k8mA-4xgtA:
undetectable		 3k8mA-4xgtA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 ARG A1063
ASP A 300
GLN A 562
 None
 0.71A 3lcvB-4xgtA:
3.4		 3lcvB-4xgtA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 HIS A 949
PHE A 961
PHE A 962
 None
 0.63A 3lk0D-4xgtA:
undetectable		 3lk0D-4xgtA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 MET A 843
ASN A 703
ASP A 850
LYS A 854
 None
 1.16A 3lslA-4xgtA:
undetectable
3lslD-4xgtA:
undetectable		 3lslA-4xgtA:
15.12
3lslD-4xgtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 MET A 843
ASN A 703
ASP A 850
LYS A 854
 None
 1.08A 3lslA-4xgtA:
undetectable
3lslD-4xgtA:
undetectable		 3lslA-4xgtA:
15.12
3lslD-4xgtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 MET A 843
ASN A 703
ASP A 850
LYS A 854
 None
 1.06A 3lslG-4xgtA:
undetectable		 3lslG-4xgtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 LEU A 952
LEU A 956
LEU A1067
LEU A 974
 None
 1.08A 3q1eA-4xgtA:
undetectable
3q1eC-4xgtA:
undetectable		 3q1eA-4xgtA:
7.97
3q1eC-4xgtA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 GLY A 365
ALA A 364
ASP A 594
ILE A 369
ILE A 391
 None
 0.99A 3tkgB-4xgtA:
undetectable		 3tkgB-4xgtA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.88A 3x2qC-4xgtA:
undetectable
3x2qJ-4xgtA:
undetectable		 3x2qC-4xgtA:
12.69
3x2qJ-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.85A 3x2qP-4xgtA:
undetectable
3x2qW-4xgtA:
undetectable		 3x2qP-4xgtA:
12.69
3x2qW-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 5 VAL A 555
LEU A 566
ILE A 605
ASN A 359
 None
 0.93A 4a9kB-4xgtA:
undetectable		 4a9kB-4xgtA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 11 PHE A1087
GLN A1070
ALA A1072
ALA A1074
ALA A1075
 None
 1.01A 4j6cA-4xgtA:
undetectable		 4j6cA-4xgtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 PHE A1087
GLN A1070
ALA A1072
ALA A1074
ALA A1075
 None
 1.03A 4j6dA-4xgtA:
undetectable		 4j6dA-4xgtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 PHE A1087
GLN A1070
ALA A1072
ALA A1074
ALA A1075
 None
 1.00A 4jbtA-4xgtA:
undetectable		 4jbtA-4xgtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 11 PHE A1087
GLN A1070
ALA A1072
ALA A1074
ALA A1075
 None
 1.01A 4jbtB-4xgtA:
undetectable		 4jbtB-4xgtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 LEU A 753
ARG A 735
PRO A 719
GLY A 771
 None
 0.99A 4klrB-4xgtA:
2.5		 4klrB-4xgtA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 ASN A 626
GLU A 309
GLU A 950
ARG A 917
 None
 1.03A 4mi4B-4xgtA:
undetectable
4mi4C-4xgtA:
undetectable		 4mi4B-4xgtA:
12.10
4mi4C-4xgtA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 ASN A 626
GLU A 309
GLU A 950
ARG A 917
 None
 1.01A 4mj8B-4xgtA:
undetectable
4mj8C-4xgtA:
undetectable		 4mj8B-4xgtA:
11.86
4mj8C-4xgtA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 ASP A 820
VAL A 826
ASP A 827
ALA A 787
 None
 1.16A 4nedA-4xgtA:
undetectable		 4nedA-4xgtA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 GLY A 948
LEU A 951
VAL A 624
MET A 623
ARG A 274
 None
 1.30A 4okbA-4xgtA:
undetectable		 4okbA-4xgtA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 4 ASN A 237
VAL A 257
THR A 269
ILE A 272
 None
 1.17A 4retA-4xgtA:
2.2		 4retA-4xgtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 4 ASN A 237
VAL A 257
THR A 269
ILE A 272
 None
 1.16A 4retC-4xgtA:
2.3		 4retC-4xgtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 VAL A1017
LEU A1015
SER A1013
GLU A1012
 None
 1.10A 4zphA-4xgtA:
undetectable
4zphB-4xgtA:
undetectable		 4zphA-4xgtA:
18.03
4zphB-4xgtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 THR A 520
LEU A 517
ILE A 495
LEU A 514
 None
 0.74A 5g48A-4xgtA:
undetectable		 5g48A-4xgtA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 PHE A1043
PRO A1042
ARG A1096
ILE A1046
 None
 1.38A 5ih0A-4xgtA:
undetectable		 5ih0A-4xgtA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 LYS A 490
ASP A 488
ILE A 498
 None
 0.75A 5kc4E-4xgtA:
undetectable		 5kc4E-4xgtA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 5 LEU A 992
LEU A 988
MET A1049
GLN A1039
 None
 1.34A 5uc3A-4xgtA:
undetectable		 5uc3A-4xgtA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 LEU A 371
PHE A 440
ILE A 369
ALA A 575
GLY A 579
 None
 0.96A 5veuA-4xgtA:
1.9		 5veuA-4xgtA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.84A 5z85C-4xgtA:
undetectable
5z85J-4xgtA:
undetectable		 5z85C-4xgtA:
12.69
5z85J-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.74A 5zcoC-4xgtA:
undetectable
5zcoJ-4xgtA:
undetectable		 5zcoC-4xgtA:
12.69
5zcoJ-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.83A 5zcqC-4xgtA:
undetectable
5zcqJ-4xgtA:
undetectable		 5zcqC-4xgtA:
12.69
5zcqJ-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.88A 5zcqP-4xgtA:
undetectable
5zcqW-4xgtA:
undetectable		 5zcqP-4xgtA:
12.69
5zcqW-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 5 ASP A 256
ARG A1059
GLN A 238
MET A 545
 None
 1.34A 5zrfB-4xgtA:
3.6		 5zrfB-4xgtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 GLU A 137
THR A 355
PRO A 356
PRO A 135
 None
 1.13A 6a4iA-4xgtA:
3.0		 6a4iA-4xgtA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 GLU A 137
THR A 355
PRO A 356
PRO A 135
 None
 1.00A 6a4iB-4xgtA:
undetectable		 6a4iB-4xgtA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 GLN A 185
VAL A 200
ARG A 175
PRO A 173
 None
 1.21A 6brdB-4xgtA:
undetectable		 6brdB-4xgtA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		6 / 12 LEU A 517
GLN A 494
LEU A 492
PRO A 493
ILE A1098
VAL A1099
 None
 1.46A 6debB-4xgtA:
2.5		 6debB-4xgtA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 GLN A 647
ASN A 329
PRO A 328
ILE A 327
 None
 1.07A 6hzpA-4xgtA:
2.0		 6hzpA-4xgtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4xgt FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 ILE A 671
GLN A 884
GLU A 880
VAL A 677
 None
 1.19A 6j20A-4xgtA:
undetectable		 6j20A-4xgtA:
16.99