SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 CYH A 189
SER A 187
LEU A 145
LEU A 139
TYR A 141
 None
SO4  A 501 ( 4.6A)
None
None
None
 0.97A 1fm6D-4xguA:
undetectable		 1fm6D-4xguA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 CYH A 189
SER A 187
LEU A 145
LEU A 139
TYR A 141
 None
SO4  A 501 ( 4.6A)
None
None
None
 1.15A 1fm6X-4xguA:
undetectable		 1fm6X-4xguA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 ILE A  90
ALA A  13
PHE A  33
LEU A  36
ILE A  37
 None
 1.09A 1g5yB-4xguA:
undetectable		 1g5yB-4xguA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		4 / 4 LEU A 390
PRO A 391
LEU A 393
ARG A 422
 None
 1.38A 1hrkB-4xguA:
2.4		 1hrkB-4xguA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		4 / 4 LEU A 390
PRO A 391
LEU A 393
ARG A 422
 None
 1.36A 2hrcB-4xguA:
2.6		 2hrcB-4xguA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 11 LEU A 192
GLY A 191
SER A 187
VAL A 319
VAL A 149
 None
None
SO4  A 501 ( 4.6A)
None
None
 0.87A 2kawA-4xguA:
undetectable		 2kawA-4xguA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		4 / 4 LEU A 390
PRO A 391
LEU A 393
ARG A 422
 None
 1.45A 2pnjB-4xguA:
2.5		 2pnjB-4xguA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 9 ARG A 419
ILE A 387
ALA A 415
LEU A 331
VAL A 394
 None
 1.45A 3o01A-4xguA:
undetectable
3o01B-4xguA:
undetectable		 3o01A-4xguA:
22.86
3o01B-4xguA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 LEU A 411
ALA A 415
GLU A 418
LEU A 393
ILE A 403
 None
 0.94A 3olsB-4xguA:
undetectable		 3olsB-4xguA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 11 ILE A 284
ILE A 236
PHE A 233
ILE A 251
GLU A 211
 None
 1.07A 3tmzA-4xguA:
undetectable		 3tmzA-4xguA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		4 / 4 PRO A 391
LEU A 338
ILE A 341
ARG A 340
 None
 1.36A 3w1wA-4xguA:
2.4		 3w1wA-4xguA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 VAL A 254
VAL A 149
ILE A 295
LEU A 294
VAL A 153
 None
 1.11A 3w68B-4xguA:
undetectable		 3w68B-4xguA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		4 / 4 PRO A 391
LEU A 338
ILE A 341
ARG A 340
 None
 1.18A 4f4dA-4xguA:
undetectable		 4f4dA-4xguA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		3 / 3 ARG A 340
TYR A 328
ASN A 138
 None
 0.76A 4ffwB-4xguA:
undetectable		 4ffwB-4xguA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 LEU A 382
GLU A 337
ALA A 415
PHE A 412
LEU A 372
 None
 1.14A 4hytA-4xguA:
undetectable		 4hytA-4xguA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 LEU A 382
GLU A 337
ALA A 415
PHE A 412
LEU A 372
 None
 1.14A 4hytC-4xguA:
undetectable		 4hytC-4xguA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		4 / 6 LEU A 188
ASP A  78
GLU A 148
ALA A 154
 None
 1.15A 4nkvC-4xguA:
undetectable		 4nkvC-4xguA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 ILE A 135
LEU A 139
VAL A 319
GLY A 179
PRO A 180
 None
 1.03A 5ienA-4xguA:
undetectable		 5ienA-4xguA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 ILE A 135
LEU A 139
VAL A 319
LEU A 296
GLY A 179
 None
 0.95A 5ienA-4xguA:
undetectable		 5ienA-4xguA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 12 CYH A 189
SER A 187
LEU A 145
LEU A 139
TYR A 141
 None
SO4  A 501 ( 4.6A)
None
None
None
 1.13A 5y2oA-4xguA:
undetectable		 5y2oA-4xguA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2
(Caenorhabditis
elegans) 		5 / 10 LEU A 280
ILE A 236
PHE A 248
LEU A 296
LEU A 174
 None
 1.27A 5y7pD-4xguA:
undetectable		 5y7pD-4xguA:
22.17