SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A  31
TYR A 188
LEU A 179
LEU A  18
ILE A  46
 None
 1.23A 1fmlB-4xgxA:
undetectable		 1fmlB-4xgxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		3 / 3 ASP A  51
ASP A  53
LYS A  61
 None
 0.99A 1lqtB-4xgxA:
undetectable		 1lqtB-4xgxA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		3 / 3 ASP A  51
ASP A  53
LYS A  61
 None
 0.99A 1lquB-4xgxA:
undetectable		 1lquB-4xgxA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		5 / 11 ILE A 308
VAL A 298
LEU A 327
ALA A 224
VAL A 226
 None
 0.93A 1rv7A-4xgxA:
undetectable
1rv7B-4xgxA:
undetectable		 1rv7A-4xgxA:
16.72
1rv7B-4xgxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		4 / 7 THR A 166
VAL A 288
GLY A 285
THR A  98
 ADP  A 403 ( 3.1A)
ADP  A 403 ( 4.9A)
None
None
 0.87A 2a1mA-4xgxA:
undetectable		 2a1mA-4xgxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		4 / 8 GLY A 193
GLY A 170
ALA A 172
ALA A 173
 None
 0.57A 2ej3A-4xgxA:
undetectable		 2ej3A-4xgxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		5 / 10 ILE A 104
MET A  23
TYR A 161
LEU A  66
LEU A  57
 ADP  A 403 ( 4.9A)
None
None
None
None
 1.27A 2w98A-4xgxA:
undetectable		 2w98A-4xgxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		5 / 9 PRO A 274
GLY A 232
ALA A 273
ALA A 281
LEU A 303
 NO3  A 406 (-3.3A)
None
NO3  A 406 (-4.4A)
None
None
 1.45A 3ur0C-4xgxA:
undetectable		 3ur0C-4xgxA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A  28
TRP A  27
GLY A  20
 None
 1.01A 4e7cA-4xgxA:
undetectable		 4e7cA-4xgxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		5 / 12 ASP A 163
ILE A 254
PRO A 256
THR A 284
VAL A 288
 ADP  A 403 (-3.0A)
ADP  A 403 (-4.5A)
ADP  A 403 ( 4.1A)
MG  A 401 (-3.6A)
ADP  A 403 ( 4.9A)
 0.53A 4xdrA-4xgxA:
14.8		 4xdrA-4xgxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A 110
ILE A 254
PRO A 256
THR A 284
VAL A 288
 ADP  A 403 ( 3.7A)
ADP  A 403 (-4.5A)
ADP  A 403 ( 4.1A)
MG  A 401 (-3.6A)
ADP  A 403 ( 4.9A)
 0.69A 4xdrA-4xgxA:
14.8		 4xdrA-4xgxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		3 / 3 ILE A  31
PRO A  32
ILE A  34
 None
 0.44A 5hw8F-4xgxA:
undetectable		 5hw8F-4xgxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4xgx FAD:PROTEIN FMN
TRANSFERASE
(Escherichia
coli) 		4 / 4 VAL A 110
GLY A 107
ASP A 163
ASP A 103
 ADP  A 403 ( 3.7A)
None
ADP  A 403 (-3.0A)
None
 1.03A 6cjkC-4xgxA:
undetectable		 6cjkC-4xgxA:
19.59