SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETB_2_T442129_1 (TRANSTHYRETIN)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	4 / 6	LEU A 44 GLU A 32 THR A 118 LEU A 42	CRO A 66 ( 4.4A) None None CRO A 66 ( 4.7A)	1.19A	1etb2-4xgyA: 0.7	1etb2-4xgyA: 17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJ6_A_AZMA400_1 (CARBONIC ANHYDRASE XIV)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	5 / 10	HIS A 194 LEU A 53 LEU A 64 THR A 62 THR A 63	None None CRO A 66 ( 4.2A) CRO A 66 ( 4.6A) None	1.39A	1rj6A-4xgyA: undetectable	1rj6A-4xgyA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJ6_B_AZMB401_1 (CARBONIC ANHYDRASE XIV)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	5 / 10	HIS A 194 LEU A 53 LEU A 64 THR A 62 THR A 63	None None CRO A 66 ( 4.2A) CRO A 66 ( 4.6A) None	1.37A	1rj6B-4xgyA: undetectable	1rj6B-4xgyA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q6F_C_010C6_0 (INFECTIOUS BRONCHITIS VIRUS (IBV) MAIN PROTEASE N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Vibrio parahaemolyticus ; Aequorea victoria; synthetic construct)	3 / 3	ASN A 170 LEU A 141 HIS A 169	None	0.79A	2q6fB-4xgyA: 0.9	2q6fB-4xgyA: 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IK6_H_HCZH800_1 (GLUTAMATE RECEPTOR 2)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	4 / 4	LYS A 41 SER A 215 LEU A 234 SER A 218	PE5 A 301 (-2.5A) None PE5 A 301 (-4.1A) CRO A 66 ( 3.2A)	1.45A	3ik6H-4xgyA: 0.0	3ik6H-4xgyA: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ILU_H_HFZH800_1 (GLUTAMATE RECEPTOR 2)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	4 / 5	LYS A 41 SER A 215 LEU A 234 SER A 218	PE5 A 301 (-2.5A) None PE5 A 301 (-4.1A) CRO A 66 ( 3.2A)	1.48A	3iluH-4xgyA: undetectable	3iluH-4xgyA: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGY_A_GLYA510_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Vibrio parahaemolyticus ; Aequorea victoria; synthetic construct)	4 / 6	ILE A 201 PHE A 83 ALA A 87 ASN A 198	None	1.14A	3pgyA-4xgyA: undetectable 3pgyB-4xgyA: undetectable	3pgyA-4xgyA: 21.41 3pgyB-4xgyA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3R_B_9PLB501_1 (CYTOCHROME P450 2A6)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	5 / 9	PHE A 71 VAL A 112 ASN A 121 ILE A 14 PHE A 8	None CRO A 66 ( 4.8A) CRO A 66 ( 3.6A) None None	1.19A	3t3rB-4xgyA: undetectable	3t3rB-4xgyA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3R_C_9PLC501_1 (CYTOCHROME P450 2A6)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	5 / 9	PHE A 71 VAL A 112 ASN A 121 ILE A 14 PHE A 8	None CRO A 66 ( 4.8A) CRO A 66 ( 3.6A) None None	1.22A	3t3rC-4xgyA: undetectable	3t3rC-4xgyA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3R_D_9PLD501_1 (CYTOCHROME P450 2A6)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	5 / 10	PHE A 71 VAL A 112 ASN A 121 ILE A 14 PHE A 8	None CRO A 66 ( 4.8A) CRO A 66 ( 3.6A) None None	1.17A	3t3rD-4xgyA: undetectable	3t3rD-4xgyA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O1Z_A_MXMA807_2 (PROSTAGLANDIN G/H SYNTHASE 1)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Aequorea victoria; Vibrio parahaemolyticus ; synthetic construct)	4 / 6	VAL A 55 LEU A 53 LEU A 125 PHE A 165	None None None CRO A 66 ( 4.0A)	1.00A	4o1zA-4xgyA: undetectable	4o1zA-4xgyA: 20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QLG_B_FOLB201_0 (DIHYDROFOLATE REDUCTASE)	4xgy	GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN (Vibrio parahaemolyticus ; Aequorea victoria; synthetic construct)	6 / 12	ALA A 110 LEU A 64 ILE A 14 LEU A 42 TYR A 92 THR A 108	None CRO A 66 ( 4.2A) None CRO A 66 ( 4.7A) None None	1.44A	4qlgB-4xgyA: undetectable	4qlgB-4xgyA: 16.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ETB_2_T442129_1","TRANSTHYRETIN","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",4,"LEU A  44;GLU A  32;THR A 118;LEU A  42","CRO A  66 ( 4.4A);None;None;CRO A  66 ( 4.7A)","1.19A","1etb2-4xgyA:0.7","1etb2-4xgyA:17.99"],["1RJ6_A_AZMA400_1","CARBONIC ANHYDRASE XIV","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",5,"HIS A 194;LEU A  53;LEU A  64;THR A  62;THR A  63","None;None;CRO A  66 ( 4.2A);CRO A  66 ( 4.6A);None","1.39A","1rj6A-4xgyA:undetectable","1rj6A-4xgyA:21.10"],["1RJ6_B_AZMB401_1","CARBONIC ANHYDRASE XIV","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",5,"HIS A 194;LEU A  53;LEU A  64;THR A  62;THR A  63","None;None;CRO A  66 ( 4.2A);CRO A  66 ( 4.6A);None","1.37A","1rj6B-4xgyA:undetectable","1rj6B-4xgyA:21.10"],["2Q6F_C_010C6_0","INFECTIOUS BRONCHITIS VIRUS (IBV) MAIN PROTEASE;N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Vibrio parahaemolyticus;Aequorea victoria;synthetic construct",3,"ASN A 170;LEU A 141;HIS A 169","None","0.79A","2q6fB-4xgyA:0.9","2q6fB-4xgyA:22.80"],["3IK6_H_HCZH800_1","GLUTAMATE RECEPTOR 2","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",4,"LYS A  41;SER A 215;LEU A 234;SER A 218","PE5 A 301 (-2.5A);None;PE5 A 301 (-4.1A);CRO A  66 ( 3.2A)","1.45A","3ik6H-4xgyA:0.0","3ik6H-4xgyA:21.77"],["3ILU_H_HFZH800_1","GLUTAMATE RECEPTOR 2","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",4,"LYS A  41;SER A 215;LEU A 234;SER A 218","PE5 A 301 (-2.5A);None;PE5 A 301 (-4.1A);CRO A  66 ( 3.2A)","1.48A","3iluH-4xgyA:undetectable","3iluH-4xgyA:21.77"],["3PGY_A_GLYA510_0","SERINE HYDROXYMETHYLTRANSFERASE","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Vibrio parahaemolyticus;Aequorea victoria;synthetic construct",4,"ILE A 201;PHE A  83;ALA A  87;ASN A 198","None","1.14A","3pgyA-4xgyA:undetectable;3pgyB-4xgyA:undetectable","3pgyA-4xgyA:21.41;3pgyB-4xgyA:21.41"],["3T3R_B_9PLB501_1","CYTOCHROME P450 2A6","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",5,"PHE A  71;VAL A 112;ASN A 121;ILE A  14;PHE A   8","None;CRO A  66 ( 4.8A);CRO A  66 ( 3.6A);None;None","1.19A","3t3rB-4xgyA:undetectable","3t3rB-4xgyA:19.79"],["3T3R_C_9PLC501_1","CYTOCHROME P450 2A6","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",5,"PHE A  71;VAL A 112;ASN A 121;ILE A  14;PHE A   8","None;CRO A  66 ( 4.8A);CRO A  66 ( 3.6A);None;None","1.22A","3t3rC-4xgyA:undetectable","3t3rC-4xgyA:19.79"],["3T3R_D_9PLD501_1","CYTOCHROME P450 2A6","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",5,"PHE A  71;VAL A 112;ASN A 121;ILE A  14;PHE A   8","None;CRO A  66 ( 4.8A);CRO A  66 ( 3.6A);None;None","1.17A","3t3rD-4xgyA:undetectable","3t3rD-4xgyA:19.79"],["4O1Z_A_MXMA807_2","PROSTAGLANDIN G\/H SYNTHASE 1","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Aequorea victoria;Vibrio parahaemolyticus;synthetic construct",4,"VAL A  55;LEU A  53;LEU A 125;PHE A 165","None;None;None;CRO A  66 ( 4.0A)","1.00A","4o1zA-4xgyA:undetectable","4o1zA-4xgyA:20.03"],["4QLG_B_FOLB201_0","DIHYDROFOLATE REDUCTASE","4xgy","GREEN FLUORESCENT PROTEIN, MAB LCDR3, GREEN FLUORESCENT PROTEIN","Vibrio parahaemolyticus;Aequorea victoria;synthetic construct",6,"ALA A 110;LEU A  64;ILE A  14;LEU A  42;TYR A  92;THR A 108","None;CRO A  66 ( 4.2A);None;CRO A  66 ( 4.7A);None;None","1.44A","4qlgB-4xgyA:undetectable","4qlgB-4xgyA:16.18"]]