SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xh3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens) 		4 / 5 GLU A  45
ALA A  48
GLU A  49
ASN A 227
 None
 1.33A 5dwkC-4xh3A:
5.5		 5dwkC-4xh3A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens) 		4 / 4 ILE A 124
ILE A  54
ARG A  50
LEU A 125
 None
 1.19A 5dzkh-4xh3A:
undetectable
5dzkn-4xh3A:
undetectable
5dzkv-4xh3A:
undetectable		 5dzkh-4xh3A:
19.61
5dzkn-4xh3A:
19.61
5dzkv-4xh3A:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens) 		3 / 3 THR A 140
SER A 139
TYR A 121
 None
 0.84A 5jsdA-4xh3A:
undetectable		 5jsdA-4xh3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens) 		3 / 3 THR A 140
SER A 139
TYR A 121
 None
 0.85A 5jsdB-4xh3A:
undetectable		 5jsdB-4xh3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens) 		3 / 3 THR A 140
SER A 139
TYR A 121
 None
 0.84A 5jsdC-4xh3A:
undetectable		 5jsdC-4xh3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens) 		3 / 3 THR A 140
SER A 139
TYR A 121
 None
 0.83A 5jseA-4xh3A:
undetectable		 5jseA-4xh3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens) 		3 / 3 THR A 140
SER A 139
TYR A 121
 None
 0.83A 5jseB-4xh3A:
undetectable		 5jseB-4xh3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4xh3 ACTIN-BINDING
PROTEIN ANILLIN
(Homo
sapiens) 		3 / 3 THR A 140
SER A 139
TYR A 121
 None
 0.84A 5jseC-4xh3A:
undetectable		 5jseC-4xh3A:
19.12