SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xh9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		4 / 6 ARG A 292
TYR A 200
PHE A 289
PHE A 219
 None
 1.45A 1e73M-4xh9A:
undetectable		 1e73M-4xh9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		5 / 12 MET A 182
LEU A 253
LEU A 232
ILE A 343
VAL A 349
 None
 1.35A 1hrkB-4xh9A:
undetectable		 1hrkB-4xh9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		5 / 12 ARG A 292
LEU A 290
ASP A 202
ARG A 197
ILE A 218
 None
 1.44A 1i6vC-4xh9A:
undetectable		 1i6vC-4xh9A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		5 / 12 CYH A 495
LEU A 410
LEU A 405
ILE A 403
LEU A 436
 None
 1.23A 1xdkB-4xh9A:
undetectable		 1xdkB-4xh9A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 253
GLY A 250
ILE A 249
ILE A 236
LEU A 232
 None
 1.01A 2kawA-4xh9A:
undetectable		 2kawA-4xh9A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		5 / 10 TYR A 424
TYR A 365
ASP A 278
ALA A 275
TYR A 364
 None
 1.40A 3rodC-4xh9A:
undetectable		 3rodC-4xh9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		4 / 4 PRO A 311
LEU A 315
ILE A 353
ARG A 264
 None
 1.30A 3w1wA-4xh9A:
undetectable		 3w1wA-4xh9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 414
HIS A 399
TYR A 427
 None
 0.60A 4fu8A-4xh9A:
undetectable		 4fu8A-4xh9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 414
HIS A 399
TYR A 427
 None
 0.69A 4fu9A-4xh9A:
undetectable		 4fu9A-4xh9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		4 / 4 THR A 245
ARG A 175
GLU A 172
VAL A 246
 None
 1.42A 4odoC-4xh9A:
undetectable		 4odoC-4xh9A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 193
ILE A 310
TYR A 318
 None
 0.69A 5uunB-4xh9A:
undetectable		 5uunB-4xh9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens) 		4 / 4 ILE A 431
LEU A 405
HIS A 503
ALA A 499
 None
 0.75A 6ck2C-4xh9A:
undetectable
6ck2D-4xh9A:
undetectable		 6ck2C-4xh9A:
5.58
6ck2D-4xh9A:
8.78