SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		4 / 7 PHE A 484
ILE A 466
ILE A 469
LYS A 470
 None
 0.98A 1sbrB-4xhcA:
undetectable		 1sbrB-4xhcA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		4 / 6 LYS A 347
LEU A 345
ALA A 350
VAL A 354
 None
 1.07A 1sn5A-4xhcA:
undetectable		 1sn5A-4xhcA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 PHE A 282
ALA A 351
LEU A 384
ARG A 231
LEU A 320
 None
 0.91A 1xdkF-4xhcA:
undetectable		 1xdkF-4xhcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 LEU A 205
ASN A 209
CYH A 210
GLY A 218
SER A  81
 None
 0.88A 2bxeB-4xhcA:
2.4		 2bxeB-4xhcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 ALA A 102
VAL A 163
GLY A  72
GLU A 159
VAL A  40
 None
 1.08A 3c6gB-4xhcA:
undetectable		 3c6gB-4xhcA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 GLY A 218
LEU A 235
ASN A 294
VAL A 291
ASP A 229
 None
None
None
None
RAM  A 900 (-2.7A)
 0.93A 3embA-4xhcA:
undetectable		 3embA-4xhcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 ALA A 419
LEU A 384
LEU A 320
ARG A 380
LEU A 359
 None
 1.14A 3k2hA-4xhcA:
undetectable		 3k2hA-4xhcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		3 / 3 ARG A 428
GLU A 435
TYR A 452
 SO4  A 901 (-3.7A)
None
None
 0.87A 3k37B-4xhcA:
undetectable		 3k37B-4xhcA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		4 / 7 LEU A  50
SER A 505
ASP A 482
THR A 206
 None
 0.93A 3lm8A-4xhcA:
undetectable
3lm8C-4xhcA:
undetectable		 3lm8A-4xhcA:
14.44
3lm8C-4xhcA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		3 / 3 ASN A 267
TRP A 226
ASP A 278
 None
RAM  A 900 (-3.8A)
None
 1.09A 4a7tA-4xhcA:
undetectable
4a7tF-4xhcA:
undetectable		 4a7tA-4xhcA:
16.56
4a7tF-4xhcA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		4 / 8 THR A 191
GLY A 522
ARG A 462
ILE A 518
 None
 1.00A 4e1vG-4xhcA:
undetectable		 4e1vG-4xhcA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		4 / 4 LYS A 347
LEU A 345
ALA A 350
VAL A 354
 None
 1.10A 4ik6A-4xhcA:
undetectable		 4ik6A-4xhcA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 LEU A 205
ASN A 209
CYH A 210
GLY A 218
SER A  81
 None
 0.96A 4ot2A-4xhcA:
2.5		 4ot2A-4xhcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 LEU A 205
ASN A 209
CYH A 210
GLY A 218
SER A  81
 None
 0.93A 4zbrA-4xhcA:
2.9		 4zbrA-4xhcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		3 / 3 ASP A 290
ARG A 361
TYR A 293
 None
 0.92A 5a7mA-4xhcA:
undetectable		 5a7mA-4xhcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		3 / 3 ASP A 290
ARG A 361
TYR A 293
 None
 0.91A 5a7mB-4xhcA:
undetectable		 5a7mB-4xhcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		4 / 5 LYS A 347
LEU A 345
ALA A 350
VAL A 354
 None
 1.17A 5cr1A-4xhcA:
undetectable		 5cr1A-4xhcA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 LEU A  61
PHE A  64
LEU A 104
ILE A 145
LEU A 147
 None
 1.26A 5ienA-4xhcA:
undetectable		 5ienA-4xhcA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 VAL A 270
LEU A 308
THR A 304
ARG A  27
LEU A  26
 None
 1.32A 5m50E-4xhcA:
undetectable		 5m50E-4xhcA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		5 / 12 GLY A 109
PHE A 153
PHE A  89
LEU A 136
PHE A 108
 None
 1.37A 5nknA-4xhcA:
undetectable		 5nknA-4xhcA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		4 / 4 PHE A 288
LEU A 373
LEU A 365
VAL A 316
 None
 1.36A 5xxiA-4xhcA:
undetectable		 5xxiA-4xhcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4xhc ALPHA-L-RHAMNOSIDASE
(Klebsiella
oxytoca) 		4 / 6 TYR A 155
ILE A  76
ALA A  39
ASP A 482
 None
 1.01A 6hu9m-4xhcA:
undetectable
6hu9q-4xhcA:
undetectable		 6hu9m-4xhcA:
21.16
6hu9q-4xhcA:
12.85