SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xhf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC
(Shewanella
oneidensis) 		5 / 12 GLY A 151
MET A 235
PHE A 239
GLY A 164
VAL A 155
 None
 1.30A 2fqyA-4xhfA:
undetectable		 2fqyA-4xhfA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC
(Shewanella
oneidensis) 		4 / 5 PHE A 247
PHE A 248
PHE A 239
VAL A 123
 None
 1.16A 2lh6A-4xhfA:
undetectable		 2lh6A-4xhfA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC
(Shewanella
oneidensis) 		3 / 3 LEU A  78
ASN A 119
ARG A 117
 None
 0.97A 2qhfA-4xhfA:
undetectable		 2qhfA-4xhfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC
(Shewanella
oneidensis) 		4 / 5 GLY A 142
TRP A 238
ALA A 112
PHE A 201
 None
 1.42A 3wqwA-4xhfA:
undetectable		 3wqwA-4xhfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC
(Shewanella
oneidensis) 		4 / 8 VAL A 166
VAL A 167
ASP A 182
PHE A 179
 None
 0.69A 3wzeA-4xhfA:
undetectable		 3wzeA-4xhfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC
(Shewanella
oneidensis) 		5 / 12 ILE A 162
ALA A 154
ALA A  53
ILE A 215
HIS A 216
 None
 1.11A 4nqaH-4xhfA:
undetectable		 4nqaH-4xhfA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC
(Shewanella
oneidensis) 		4 / 5 PHE A 239
PHE A 247
PHE A 248
VAL A 138
 None
 1.11A 5a1rA-4xhfA:
undetectable		 5a1rA-4xhfA:
19.06