SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		4 / 5 LEU A  89
LEU A  92
LEU A 293
MET A 136
 None
 1.12A 2oaxF-4xhgA:
undetectable		 2oaxF-4xhgA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		4 / 7 CYH A 207
PHE A 273
PHE A 102
TYR A 282
 None
 1.45A 3hggA-4xhgA:
undetectable		 3hggA-4xhgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		5 / 12 ASP A  91
ASP A 289
PHE A 342
PHE A 102
TYR A 205
 ADP  A 501 ( 4.9A)
None
None
None
None
 1.07A 3pwwA-4xhgA:
undetectable		 3pwwA-4xhgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		5 / 12 ASP A 261
ASP A 195
GLY A 121
LEU A 196
PHE A 150
 None
 1.09A 3pwwA-4xhgA:
undetectable		 3pwwA-4xhgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		5 / 12 ILE A 129
ASP A 195
ASP A 194
ILE A 125
GLU A 189
 None
 1.32A 4i41A-4xhgA:
21.4		 4i41A-4xhgA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		5 / 12 GLU A  40
ILE A  37
ALA A  36
VAL A  35
PHE A   9
 None
None
ADP  A 501 ( 3.7A)
None
None
 1.04A 4u8yB-4xhgA:
undetectable		 4u8yB-4xhgA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		5 / 12 GLU A  40
ILE A  37
ALA A  36
VAL A  35
PHE A   9
 None
None
ADP  A 501 ( 3.7A)
None
None
 1.06A 4u95B-4xhgA:
undetectable		 4u95B-4xhgA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		4 / 6 ARG A 115
PRO A  66
ARG A 141
THR A 144
 None
 1.38A 5ih0A-4xhgA:
7.9		 5ih0A-4xhgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4xhg SIMILAR TO
UNIPROT|P29295
SACCHAROMYCES
CEREVISIAE YPL204W
HRR25
([Candida]
glabrata) 		3 / 3 CYH A 241
MET A 252
ASN A 253
 None
 1.33A 5qh8A-4xhgA:
undetectable		 5qh8A-4xhgA:
19.30