SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xhj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		3 / 3 MET A 590
LEU A 593
SER A 594
 None
 0.56A 1ee2A-4xhjA:
undetectable		 1ee2A-4xhjA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 12 MET A 536
ALA A 509
ILE A 744
ARG A 483
LEU A 498
 None
 1.11A 1eiiA-4xhjA:
undetectable		 1eiiA-4xhjA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifA-4xhjA:
undetectable		 1kifA-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifB-4xhjA:
undetectable		 1kifB-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifC-4xhjA:
undetectable		 1kifC-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifD-4xhjA:
undetectable		 1kifD-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifE-4xhjA:
undetectable		 1kifE-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifF-4xhjA:
undetectable		 1kifF-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifG-4xhjA:
undetectable		 1kifG-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifH-4xhjA:
undetectable		 1kifH-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		3 / 3 ASP B 152
PHE B 155
VAL A 224
 None
 0.71A 1kijB-4xhjB:
undetectable		 1kijB-4xhjB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 11 ARG A 163
THR A 169
GLY A 175
GLU A 332
GLU A 331
 None
 1.31A 1odiA-4xhjA:
undetectable		 1odiA-4xhjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 11 ARG A 163
THR A 169
GLY A 175
GLU A 332
GLU A 331
 None
 1.30A 1odiB-4xhjA:
undetectable		 1odiB-4xhjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 11 ARG A 163
THR A 169
GLY A 175
GLU A 332
GLU A 331
 None
 1.34A 1odiD-4xhjA:
undetectable		 1odiD-4xhjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 11 ARG A 163
THR A 169
GLY A 175
GLU A 332
GLU A 331
 None
 1.29A 1odiE-4xhjA:
undetectable		 1odiE-4xhjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 11 ARG A 163
THR A 169
GLY A 175
GLU A 332
GLU A 331
 None
 1.35A 1odiF-4xhjA:
undetectable		 1odiF-4xhjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 12 ASN A 551
ILE A 552
GLY A 555
ALA A 557
LEU A 606
 None
 0.99A 1r9oA-4xhjA:
undetectable		 1r9oA-4xhjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 GLY A 239
ILE A 426
VAL A 256
SER A 218
 None
 1.25A 1rs7A-4xhjA:
undetectable		 1rs7A-4xhjA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 7 LEU A 606
GLU A 554
LEU A 592
ALA A 618
 None
 1.16A 1sn0B-4xhjA:
undetectable
1sn0D-4xhjA:
undetectable		 1sn0B-4xhjA:
10.74
1sn0D-4xhjA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.94A 1ve9A-4xhjA:
undetectable		 1ve9A-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 7 GLY A 784
SER A 668
SER A 699
GLU A 643
 None
 1.10A 2c8aD-4xhjA:
undetectable		 2c8aD-4xhjA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 10 ALA A 202
GLN A 397
LEU A 468
LEU A 433
LEU A 390
 None
 1.40A 2ceoB-4xhjA:
undetectable		 2ceoB-4xhjA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 6 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.95A 2du8A-4xhjA:
undetectable		 2du8A-4xhjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.90A 2du8G-4xhjA:
undetectable		 2du8G-4xhjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 1.03A 2du8J-4xhjA:
undetectable		 2du8J-4xhjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 8 VAL A 589
ASN A 591
ALA A 739
ARG A 673
 None
 1.00A 2ij7C-4xhjA:
undetectable		 2ij7C-4xhjA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 PRO A 764
ILE A 744
ARG A 733
ASP A 742
 None
 1.16A 2rhmB-4xhjA:
undetectable		 2rhmB-4xhjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 5 PRO A 764
ILE A 744
ARG A 733
ASP A 742
 None
 1.31A 2rhmD-4xhjA:
undetectable		 2rhmD-4xhjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		3 / 3 LEU A 407
MET A 408
MET A 576
 None
 0.99A 2vavF-4xhjA:
undetectable		 2vavF-4xhjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 7 SER A 260
TYR A 235
VAL A 126
ILE A 274
 None
 1.24A 3bu1A-4xhjA:
undetectable		 3bu1A-4xhjA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 12 TYR A 682
ILE A 671
GLY A 784
PHE A 781
LEU A 684
 None
None
None
NAG  A 903 (-3.7A)
None
 1.18A 3em0B-4xhjA:
undetectable		 3em0B-4xhjA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		5 / 12 LEU B 107
GLY B 106
LEU B 104
ILE B  74
PHE A 132
 None
 0.81A 3gwwA-4xhjB:
undetectable		 3gwwA-4xhjB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 9 LEU A 334
PRO A 277
VAL A 256
GLY A 255
MET A 259
 None
 1.30A 3hcnB-4xhjA:
undetectable		 3hcnB-4xhjA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		3 / 3 ARG A 483
THR A 751
THR A 531
 None
 0.50A 3k2hB-4xhjA:
undetectable		 3k2hB-4xhjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		5 / 11 GLY B 112
LEU B 107
LEU A 100
LEU B 128
LEU B 125
 None
 1.05A 3ndvA-4xhjB:
undetectable
3ndvB-4xhjB:
undetectable		 3ndvA-4xhjB:
16.51
3ndvB-4xhjB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		5 / 11 LEU B 128
LEU B 125
GLY B 112
LEU B 107
LEU A 100
 None
 1.01A 3ndvA-4xhjB:
undetectable
3ndvB-4xhjB:
undetectable		 3ndvA-4xhjB:
16.51
3ndvB-4xhjB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		5 / 11 GLY B 112
LEU B 107
LEU A 100
LEU B 128
LEU B 125
 None
 1.02A 3ndvC-4xhjB:
undetectable
3ndvD-4xhjB:
undetectable		 3ndvC-4xhjB:
16.51
3ndvD-4xhjB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		5 / 11 LEU B 128
LEU B 125
GLY B 112
LEU B 107
LEU A 100
 None
 1.06A 3ndvC-4xhjB:
undetectable
3ndvD-4xhjB:
undetectable		 3ndvC-4xhjB:
16.51
3ndvD-4xhjB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 6 ILE A 274
HIS A 223
PRO A 128
LEU A 282
 None
 1.22A 3oi8A-4xhjA:
undetectable		 3oi8A-4xhjA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		3 / 3 TYR A 682
TYR A 669
GLU A 706
 None
 0.83A 3pfgA-4xhjA:
undetectable		 3pfgA-4xhjA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		5 / 12 PHE A 149
PRO B 143
GLY A 313
ASN A 317
LEU A 226
 None
 1.09A 4kotA-4xhjA:
0.0		 4kotA-4xhjA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		5 / 10 PHE A 149
PRO B 143
GLY A 313
ASN A 317
LEU A 226
 None
 1.11A 4kouA-4xhjA:
undetectable		 4kouA-4xhjA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		5 / 12 PHE A 149
PRO B 143
GLY A 313
ASN A 317
LEU A 226
 None
 1.11A 4kowA-4xhjA:
undetectable		 4kowA-4xhjA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 4 HIS A 321
GLU A 362
HIS A 366
LEU A 273
 None
 1.25A 4m2rA-4xhjA:
undetectable		 4m2rA-4xhjA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 12 TYR A 364
GLY A 268
SER A 266
ILE A 271
GLY A 313
 None
 1.27A 4obwC-4xhjA:
undetectable		 4obwC-4xhjA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 11 ARG A 483
SER A 487
ARG A 482
LEU A 535
LEU A 462
 None
 1.21A 4or0A-4xhjA:
undetectable		 4or0A-4xhjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		3 / 3 MET A 350
MET A 342
TYR A 364
 None
 1.40A 4p6xI-4xhjA:
undetectable		 4p6xI-4xhjA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		3 / 3 ILE A 743
ASP A 582
ARG A 733
 None
 0.72A 4pstA-4xhjA:
undetectable		 4pstA-4xhjA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4xhj ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3) 		4 / 6 LYS B  36
PRO B  37
LEU B  43
GLU B  47
 None
 1.35A 4z4cA-4xhjB:
undetectable		 4z4cA-4xhjB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 4 VAL A 696
ILE A 693
ASN A 674
VAL A 658
 None
 1.17A 5ajqA-4xhjA:
undetectable		 5ajqA-4xhjA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 6 SER A 260
HIS A 223
PRO A 225
LEU A 262
 None
 1.29A 5dzka-4xhjA:
undetectable
5dzko-4xhjA:
undetectable		 5dzka-4xhjA:
14.07
5dzko-4xhjA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 12 VAL A 394
GLN A 397
ALA A 195
LEU A 425
SER A 423
 None
 1.21A 5hv1A-4xhjA:
1.0		 5hv1A-4xhjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L
(Human
alphaherpesvirus
3;
Human
alphaherpesvirus
3) 		3 / 3 GLN B 160
THR A 418
ASP A 246
 None
 0.71A 5k9dA-4xhjB:
undetectable		 5k9dA-4xhjB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		5 / 12 ARG A 249
SER A 267
ILE A 359
ILE A 367
ALA A 368
 None
 1.10A 5vc0A-4xhjA:
undetectable		 5vc0A-4xhjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 7 THR A 584
PHE A 620
VAL A 589
ILE A 552
 None
 1.16A 5vkqA-4xhjA:
undetectable
5vkqB-4xhjA:
undetectable		 5vkqA-4xhjA:
19.28
5vkqB-4xhjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 8 THR A 584
PHE A 620
VAL A 589
ILE A 552
 None
 1.15A 5vkqB-4xhjA:
undetectable
5vkqC-4xhjA:
undetectable		 5vkqB-4xhjA:
19.28
5vkqC-4xhjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4xhj ENVELOPE
GLYCOPROTEIN H
(Human
alphaherpesvirus
3) 		4 / 7 THR A 584
PHE A 620
VAL A 589
ILE A 552
 None
 1.13A 5vkqC-4xhjA:
undetectable
5vkqD-4xhjA:
undetectable		 5vkqC-4xhjA:
19.28
5vkqD-4xhjA:
19.28