SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xhl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 150
ARG A 115
TYR A 118
GLY A  64
ILE A  65
 None
SO4  A 404 (-2.9A)
None
None
None
 0.85A 1kglA-4xhlA:
undetectable		 1kglA-4xhlA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 293
GLN A 367
LEU A 338
THR A 296
PHE A 344
 None
 1.29A 2oaxB-4xhlA:
undetectable		 2oaxB-4xhlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 293
GLN A 367
LEU A 338
THR A 296
PHE A 344
 None
 1.30A 2oaxC-4xhlA:
undetectable		 2oaxC-4xhlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  89
LEU A  92
LEU A 293
MET A 136
 None
 1.11A 2oaxF-4xhlA:
undetectable		 2oaxF-4xhlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		4 / 7 CYH A 207
PHE A 273
PHE A 102
TYR A 282
 None
 1.30A 3hggA-4xhlA:
undetectable		 3hggA-4xhlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  68
TYR A  56
HIS A 146
LEU A  49
GLY A 137
 None
 1.14A 3ozwB-4xhlA:
undetectable		 3ozwB-4xhlA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 293
GLN A 367
LEU A 338
THR A 296
PHE A 344
 None
 1.24A 3vhuA-4xhlA:
undetectable		 3vhuA-4xhlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  40
ILE A  37
ALA A  36
VAL A  35
PHE A   9
 None
None
CKI  A 401 (-3.3A)
None
None
 0.95A 4u8yB-4xhlA:
undetectable		 4u8yB-4xhlA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  40
ILE A  37
ALA A  36
VAL A  35
PHE A   9
 None
None
CKI  A 401 (-3.3A)
None
None
 0.93A 4u95B-4xhlA:
undetectable		 4u95B-4xhlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 8 ALA A  36
GLU A  52
ILE A  82
LEU A 135
ASP A 149
 CKI  A 401 (-3.3A)
None
CKI  A 401 ( 4.1A)
None
None
 0.78A 5owrA-4xhlA:
19.4		 5owrA-4xhlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 115
ILE A 116
LEU A 203
PHE A 206
 SO4  A 404 (-2.9A)
None
None
None
 1.01A 5vc0A-4xhlA:
undetectable		 5vc0A-4xhlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4xhl CASEIN KINASE I
HOMOLOG HRR25
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 190
ASP A 195
ASP A 132
ASP A 149
ILE A 148
 None
None
None
None
CKI  A 401 ( 3.7A)
 1.39A 6fzbB-4xhlA:
0.8		 6fzbB-4xhlA:
12.95