SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xhp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 VAL A 536
ALA A 486
ARG A 532
ARG A 519
ILE A 571
 None
 1.14A 1d1gB-4xhpA:
undetectable		 1d1gB-4xhpA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 PHE A 689
ILE A 677
LYS A 809
ALA A 807
 None
 0.95A 1hk2A-4xhpA:
undetectable		 1hk2A-4xhpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A 377
GLY A 373
LEU A 237
ASP A 383
LEU A 345
 None
ADP  A 901 (-4.2A)
None
None
None
 1.15A 1jg2A-4xhpA:
undetectable		 1jg2A-4xhpA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 8 GLU A 251
VAL A 203
HIS A 517
GLU A 164
 None
 1.30A 1s3zA-4xhpA:
undetectable
1s3zB-4xhpA:
undetectable		 1s3zA-4xhpA:
10.05
1s3zB-4xhpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A 152
GLY A 153
SER A 205
LEU A 207
ALA A 410
 None
 0.90A 1v2xA-4xhpA:
undetectable		 1v2xA-4xhpA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 LEU A  27
GLY A  31
ASN A 215
ILE A 213
 None
 0.75A 1xf1B-4xhpA:
2.9		 1xf1B-4xhpA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 LEU A 470
GLY A 474
ASN A 658
ILE A 656
 None
 0.85A 1xf1B-4xhpA:
2.9		 1xf1B-4xhpA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 MET A 134
ASN A 194
GLN A 415
 None
 1.06A 1xoqB-4xhpA:
undetectable		 1xoqB-4xhpA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 GLU A  71
ASP A  69
PHE A  36
ARG A 140
 None
 1.08A 2a3bB-4xhpA:
undetectable		 2a3bB-4xhpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 747
THR A 742
VAL A 783
PHE A 746
SER A 738
 ADP  A 903 (-3.6A)
None
None
None
None
 1.50A 2gl0A-4xhpA:
undetectable
2gl0C-4xhpA:
undetectable		 2gl0A-4xhpA:
12.82
2gl0C-4xhpA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 PHE A 746
SER A 738
ILE A 747
THR A 742
VAL A 783
 None
None
ADP  A 903 (-3.6A)
None
None
 1.48A 2gl0D-4xhpA:
undetectable
2gl0E-4xhpA:
undetectable		 2gl0D-4xhpA:
12.82
2gl0E-4xhpA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 LEU A 454
LEU A 449
MET A 448
 None
 0.87A 2itzA-4xhpA:
undetectable		 2itzA-4xhpA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 LEU A  73
LEU A  11
ILE A 128
VAL A 177
ILE A 189
 None
 1.16A 2uxoB-4xhpA:
undetectable		 2uxoB-4xhpA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 VAL A 770
ASN A 363
TRP A 359
 None
 0.89A 2y00B-4xhpA:
undetectable		 2y00B-4xhpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 ILE A 513
VAL A 579
ARG A 583
 None
 0.76A 3p73A-4xhpA:
undetectable		 3p73A-4xhpA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 384
GLY A 377
GLY A 373
ASP A 350
ALA A 348
 None
None
ADP  A 901 (-4.2A)
None
None
 0.98A 3uj7B-4xhpA:
undetectable		 3uj7B-4xhpA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A 142
LYS A 187
ILE A 189
VAL A 177
LEU A  11
 None
 1.06A 4a81A-4xhpA:
undetectable		 4a81A-4xhpA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 GLY A 585
LYS A 630
ILE A 632
VAL A 620
LEU A 454
 None
 1.15A 4a81A-4xhpA:
undetectable		 4a81A-4xhpA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 SER A 205
TYR A 407
ASP A 243
 None
 0.83A 4rp8C-4xhpA:
2.2		 4rp8C-4xhpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 VAL A 770
VAL A 775
GLY A 773
PHE A 722
 None
 1.05A 5d4nA-4xhpA:
undetectable
5d4nC-4xhpA:
undetectable		 5d4nA-4xhpA:
8.55
5d4nC-4xhpA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 ILE A 811
GLY A 814
PHE A 845
TYR A 790
 None
ADP  A 903 ( 4.1A)
None
None
 0.86A 5h3aA-4xhpA:
undetectable		 5h3aA-4xhpA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 LYS A 541
ALA A 540
VAL A 536
TYR A 539
 None
 1.04A 5i8fA-4xhpA:
undetectable		 5i8fA-4xhpA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 GLY A 814
ASP A 679
ASN A 702
 ADP  A 903 ( 4.1A)
MG  A 902 (-3.1A)
None
 0.59A 5jglA-4xhpA:
undetectable		 5jglA-4xhpA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 GLY A 152
GLY A 153
SER A 205
LEU A 207
ALA A 410
 None
 1.04A 5l0zB-4xhpA:
undetectable		 5l0zB-4xhpA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 8 ASP A 236
SER A 354
ASN A 244
SER A 399
 MG  A 900 (-2.9A)
None
None
None
 1.12A 5l1fA-4xhpA:
2.3
5l1fB-4xhpA:
2.5		 5l1fA-4xhpA:
23.75
5l1fB-4xhpA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 ARG A 532
ALA A 488
GLN A 547
ILE A 485
 None
 1.32A 6g9bA-4xhpA:
undetectable
6g9bB-4xhpA:
0.7		 6g9bA-4xhpA:
6.71
6g9bB-4xhpA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4xhp PARM HYBRID FUSION
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 ARG A 532
ALA A 533
GLN A 547
ILE A 485
 None
 1.19A 6g9bA-4xhpA:
undetectable
6g9bB-4xhpA:
0.7		 6g9bA-4xhpA:
6.71
6g9bB-4xhpA:
6.04