SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4xhz PROTOCADHERIN-15
(Homo
sapiens) 		4 / 7 VAL A 891
THR A 890
PHE A 873
ARG A 836
 None
 1.27A 2kotA-4xhzA:
undetectable		 2kotA-4xhzA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 4xhz PROTOCADHERIN-15
(Homo
sapiens) 		4 / 4 SER A 795
PRO A 796
PHE A 878
PRO A 886
 None
 1.32A 3bjwA-4xhzA:
undetectable		 3bjwA-4xhzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)		 4xhz PROTOCADHERIN-15
(Homo
sapiens) 		4 / 4 SER A 795
PRO A 796
PHE A 878
PRO A 886
 None
 1.32A 3bjwG-4xhzA:
undetectable		 3bjwG-4xhzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4xhz PROTOCADHERIN-15
(Homo
sapiens) 		4 / 5 SER A 795
PRO A 796
PHE A 878
PRO A 886
 None
 1.26A 3bjwC-4xhzA:
undetectable		 3bjwC-4xhzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)		 4xhz PROTOCADHERIN-15
(Homo
sapiens) 		4 / 4 SER A 795
PRO A 796
PHE A 878
PRO A 886
 None
 1.33A 3bjwD-4xhzA:
0.0		 3bjwD-4xhzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xhz PROTOCADHERIN-15
(Homo
sapiens) 		4 / 7 ASP A 897
ASP A 931
GLU A 992
GLU A 862
 CA  A2002 (-3.0A)
CA  A2001 (-2.2A)
None
CA  A2002 ( 2.4A)
 1.16A 4fevB-4xhzA:
undetectable		 4fevB-4xhzA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xhz PROTOCADHERIN-15
(Homo
sapiens) 		4 / 8 ASP A 897
ASP A 931
GLU A 992
GLU A 862
 CA  A2002 (-3.0A)
CA  A2001 (-2.2A)
None
CA  A2002 ( 2.4A)
 1.19A 4gkhD-4xhzA:
undetectable		 4gkhD-4xhzA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xhz PROTOCADHERIN-15
(Homo
sapiens) 		4 / 8 ASP A 897
ASP A 931
GLU A 992
GLU A 862
 CA  A2002 (-3.0A)
CA  A2001 (-2.2A)
None
CA  A2002 ( 2.4A)
 0.96A 4gkiC-4xhzA:
undetectable		 4gkiC-4xhzA:
21.91