SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xi2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
4 / 8 LEU A 486
VAL A 529
CYH A 527
GLY A 480
None
1.00A 1jlfA-4xi2A:
undetectable
1jlfB-4xi2A:
undetectable
1jlfA-4xi2A:
22.41
1jlfB-4xi2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 9 LEU A 408
GLY A 409
VAL A 416
ALA A 428
TYR A 476
LEU A 528
None
0.99A 1muoA-4xi2A:
18.3
1muoA-4xi2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
4 / 6 PHE A 559
ASN A 603
ARG A 525
ASN A 526
None
1.46A 1t9uA-4xi2A:
undetectable
1t9uA-4xi2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 VAL A 416
ALA A 428
THR A 474
LEU A 512
HIS A 519
None
0.52A 1uwjA-4xi2A:
7.8
1uwjA-4xi2A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
3 / 3 ARG A 641
SER A 592
TYR A 591
None
0.66A 1x70A-4xi2A:
3.7
1x70A-4xi2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 ALA A 428
MET A 449
THR A 474
GLY A 480
CYH A 481
LEU A 483
LEU A 528
ASP A 539
PHE A 540
None
1.09A 1xkkA-4xi2A:
30.9
1xkkA-4xi2A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 MET A 449
THR A 474
GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
ASP A 539
PHE A 540
None
0.92A 1xkkA-4xi2A:
30.9
1xkkA-4xi2A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 11 GLY A 409
GLY A 411
VAL A 416
ALA A 428
TYR A 476
LEU A 528
None
0.57A 2evaA-4xi2A:
19.8
2evaA-4xi2A:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
None
0.72A 2gqgA-4xi2A:
27.4
2gqgA-4xi2A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
None
0.80A 2gqgB-4xi2A:
31.0
2gqgB-4xi2A:
31.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 9 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
None
0.71A 2xp2A-4xi2A:
31.2
2xp2A-4xi2A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LYS A 406
ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
None
0.95A 2y6oA-4xi2A:
30.4
2y6oA-4xi2A:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 10 VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
ASP A 539
None
0.68A 2y7jB-4xi2A:
23.7
2y7jB-4xi2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
None
0.67A 2zvaA-4xi2A:
25.2
2zvaA-4xi2A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 10 LEU A 408
ALA A 428
VAL A 458
MET A 477
GLY A 480
LEU A 528
None
0.51A 3aoxA-4xi2A:
25.1
3aoxA-4xi2A:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
10 / 12 VAL A 416
ALA A 428
MET A 449
LEU A 460
THR A 474
GLY A 480
LEU A 528
ASP A 539
PHE A 540
LEU A 542
None
0.87A 3bbtB-4xi2A:
30.9
3bbtB-4xi2A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 VAL A 416
ALA A 428
MET A 449
THR A 474
GLY A 480
LEU A 528
ASP A 539
PHE A 540
LEU A 542
None
0.90A 3bbtD-4xi2A:
27.0
3bbtD-4xi2A:
25.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 10 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
None
0.87A 3cs9A-4xi2A:
25.1
3cs9A-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 ALA A 428
LEU A 457
THR A 474
GLY A 480
HIS A 519
LEU A 528
None
0.89A 3cs9A-4xi2A:
25.1
3cs9A-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 ALA A 428
LEU A 457
THR A 474
GLY A 480
PHE A 517
LEU A 528
None
0.91A 3cs9A-4xi2A:
25.1
3cs9A-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 9 LEU A 408
VAL A 416
VAL A 458
ILE A 472
LEU A 528
VAL A 537
None
1.16A 3cs9B-4xi2A:
24.9
3cs9B-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 9 LEU A 408
VAL A 416
ILE A 472
MET A 477
VAL A 537
None
1.21A 3cs9C-4xi2A:
24.8
3cs9C-4xi2A:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 9 LEU A 408
VAL A 416
VAL A 458
ILE A 472
VAL A 537
None
0.94A 3cs9C-4xi2A:
24.8
3cs9C-4xi2A:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 10 LEU A 408
VAL A 416
ALA A 428
THR A 474
TYR A 476
LEU A 528
None
0.77A 3g0fB-4xi2A:
28.6
3g0fB-4xi2A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
None
0.76A 3g5dA-4xi2A:
24.3
3g5dA-4xi2A:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
None
0.73A 3g5dA-4xi2A:
24.3
3g5dA-4xi2A:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.71A 3g5dB-4xi2A:
24.4
3g5dB-4xi2A:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
None
0.77A 3k54A-4xi2A:
28.3
3k54A-4xi2A:
65.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
GLY A 409
VAL A 416
ALA A 428
VAL A 458
TYR A 476
CYH A 481
LEU A 528
None
1.26A 3lxkA-4xi2A:
27.8
3lxkA-4xi2A:
25.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 11 ALA A 428
VAL A 458
MET A 477
GLY A 480
LEU A 528
SER A 538
ASP A 539
None
0.67A 3miyA-4xi2A:
29.4
3miyA-4xi2A:
42.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 9 ALA A 428
MET A 477
GLY A 480
LEU A 528
SER A 538
None
0.57A 3miyB-4xi2A:
32.6
3miyB-4xi2A:
42.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.87A 3octA-4xi2A:
14.5
3octA-4xi2A:
97.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 GLY A 409
VAL A 416
ALA A 428
THR A 474
ASP A 539
None
0.49A 3ohtB-4xi2A:
6.1
3ohtB-4xi2A:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 ALA A 428
LEU A 457
VAL A 458
THR A 474
GLY A 480
HIS A 519
None
0.88A 3oxzA-4xi2A:
29.8
3oxzA-4xi2A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 9 ILE A 472
MET A 477
ARG A 520
LEU A 528
VAL A 537
None
1.16A 3oxzA-4xi2A:
29.7
3oxzA-4xi2A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 9 LEU A 408
ILE A 472
MET A 477
LEU A 528
VAL A 537
None
1.15A 3oxzA-4xi2A:
29.7
3oxzA-4xi2A:
38.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.71A 3qlgA-4xi2A:
24.1
3qlgA-4xi2A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
ASP A 539
None
0.84A 3qlgB-4xi2A:
24.4
3qlgB-4xi2A:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.83A 3sxrA-4xi2A:
32.0
3sxrA-4xi2A:
43.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
SER A 538
None
0.69A 3sxrA-4xi2A:
32.0
3sxrA-4xi2A:
43.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.88A 3sxrB-4xi2A:
31.7
3sxrB-4xi2A:
43.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
SER A 538
None
0.92A 3sxrB-4xi2A:
31.7
3sxrB-4xi2A:
43.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
None
0.78A 3ue4A-4xi2A:
30.3
3ue4A-4xi2A:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
None
0.85A 3ue4B-4xi2A:
30.1
3ue4B-4xi2A:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 LEU A 408
GLY A 409
ALA A 428
GLY A 480
PHE A 540
LEU A 542
None
1.00A 3wzdA-4xi2A:
29.3
3wzdA-4xi2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 9 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
None
0.65A 4anqA-4xi2A:
31.3
4anqA-4xi2A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 9 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
None
0.66A 4ansA-4xi2A:
31.2
4ansA-4xi2A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 10 LEU A 408
GLY A 409
VAL A 416
ALA A 428
TYR A 476
LEU A 528
None
0.50A 4ckjA-4xi2A:
27.8
4ckjA-4xi2A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 LEU A 408
VAL A 416
ALA A 428
THR A 474
MET A 477
GLY A 480
CYH A 481
LEU A 528
ASP A 539
None
0.96A 4hjoA-4xi2A:
31.8
4hjoA-4xi2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 10 ALA A 428
VAL A 458
GLY A 480
LEU A 528
SER A 538
ASP A 539
None
0.77A 4ks8A-4xi2A:
24.4
4ks8A-4xi2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 ILE A 472
ASN A 526
ASP A 539
PHE A 540
GLY A 541
MET A 437
None
1.31A 4lmnA-4xi2A:
24.9
4lmnA-4xi2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
None
0.64A 4mxoA-4xi2A:
29.9
4mxoA-4xi2A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.69A 4mxoB-4xi2A:
24.1
4mxoB-4xi2A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.72A 4mxxA-4xi2A:
24.0
4mxxA-4xi2A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
None
0.67A 4mxxB-4xi2A:
25.5
4mxxB-4xi2A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
None
0.62A 4mxyA-4xi2A:
26.4
4mxyA-4xi2A:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
TYR A 476
GLY A 480
LEU A 528
None
0.54A 4mxyB-4xi2A:
30.1
4mxyB-4xi2A:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
TYR A 476
GLY A 480
LEU A 528
None
0.62A 4mxzA-4xi2A:
26.4
4mxzA-4xi2A:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
TYR A 476
GLY A 480
LEU A 528
None
0.54A 4mxzB-4xi2A:
30.1
4mxzB-4xi2A:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 LEU A 408
VAL A 416
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
1.02A 4otwA-4xi2A:
28.0
4otwA-4xi2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 11 LEU A 408
VAL A 416
ALA A 428
TYR A 476
MET A 477
GLY A 480
ASN A 526
LEU A 528
None
0.69A 4u5jA-4xi2A:
24.4
4u5jA-4xi2A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 9 LEU A 408
VAL A 416
ALA A 428
TYR A 476
MET A 477
GLY A 480
LEU A 528
None
0.67A 4u5jB-4xi2A:
24.3
4u5jB-4xi2A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 9 LEU A 408
VAL A 416
LYS A 430
TYR A 476
MET A 477
GLY A 480
LEU A 528
None
1.08A 4u5jB-4xi2A:
24.3
4u5jB-4xi2A:
28.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 11 LEU A 408
ALA A 428
THR A 474
MET A 477
GLY A 480
ASN A 526
LEU A 528
None
0.63A 4wa9A-4xi2A:
27.8
4wa9A-4xi2A:
33.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
4 / 6 LEU A 408
ALA A 428
MET A 477
LEU A 528
None
0.73A 4wboC-4xi2A:
16.4
4wboC-4xi2A:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
None
0.77A 4xeyA-4xi2A:
30.6
4xeyA-4xi2A:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
VAL A 416
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
None
0.74A 4xeyB-4xi2A:
30.1
4xeyB-4xi2A:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
ALA A 428
VAL A 458
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
None
0.86A 4xliA-4xi2A:
24.8
4xliA-4xi2A:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.81A 4xliB-4xi2A:
27.1
4xliB-4xi2A:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
4 / 6 ALA A 428
LYS A 430
MET A 477
LEU A 528
None
0.48A 4xoyA-4xi2A:
undetectable
4xoyA-4xi2A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
4 / 6 ALA A 428
LYS A 430
MET A 477
LEU A 528
None
0.37A 4xp3A-4xi2A:
22.0
4xp3A-4xi2A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 9 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
None
0.75A 5aaaA-4xi2A:
31.8
5aaaA-4xi2A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 10 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
None
0.56A 5aacA-4xi2A:
31.4
5aacA-4xi2A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
THR A 474
GLY A 480
LEU A 528
None
0.82A 5h2uA-4xi2A:
34.0
5h2uA-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
3 / 3 ILE A 472
MET A 477
ASP A 539
None
0.68A 5h2uA-4xi2A:
34.0
5h2uA-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 LEU A 408
ALA A 428
THR A 474
GLY A 480
LEU A 528
ASP A 539
None
0.95A 5h2uC-4xi2A:
30.3
5h2uC-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
ILE A 472
LEU A 528
ASP A 539
None
0.65A 5h2uD-4xi2A:
34.0
5h2uD-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 LEU A 408
VAL A 416
ALA A 428
LYS A 430
THR A 474
LEU A 528
ASP A 539
None
0.79A 5h2uD-4xi2A:
34.0
5h2uD-4xi2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 VAL A 416
ALA A 428
ILE A 472
THR A 474
TYR A 476
PHE A 540
None
0.83A 5hesA-4xi2A:
10.0
5hesA-4xi2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 VAL A 416
ALA A 428
ILE A 472
THR A 474
TYR A 476
PHE A 540
None
0.76A 5hesB-4xi2A:
26.5
5hesB-4xi2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 GLY A 411
VAL A 416
ALA A 428
ILE A 472
THR A 474
None
0.64A 5hieA-4xi2A:
10.2
5hieA-4xi2A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 GLY A 411
VAL A 416
ALA A 428
ILE A 472
THR A 474
None
0.65A 5hieB-4xi2A:
10.2
5hieB-4xi2A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 GLY A 411
VAL A 416
ALA A 428
ILE A 472
THR A 474
None
0.66A 5hieD-4xi2A:
23.6
5hieD-4xi2A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
None
0.84A 5i9xA-4xi2A:
30.5
5i9xA-4xi2A:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 ALA A 428
THR A 474
TYR A 476
GLY A 480
LEU A 528
SER A 538
None
0.77A 5i9yA-4xi2A:
27.0
5i9yA-4xi2A:
29.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
10 / 12 GLY A 411
VAL A 416
ALA A 428
MET A 449
ILE A 472
THR A 474
GLY A 480
LEU A 528
SER A 538
PHE A 540
None
0.56A 5p9iA-4xi2A:
41.2
5p9iA-4xi2A:
94.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 GLY A 411
VAL A 416
LYS A 430
MET A 449
ILE A 472
GLY A 480
LEU A 528
SER A 538
PHE A 540
None
0.81A 5p9iA-4xi2A:
41.2
5p9iA-4xi2A:
94.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
10 / 12 VAL A 416
ALA A 428
MET A 449
ILE A 472
THR A 474
GLY A 480
ASN A 484
LEU A 528
SER A 538
PHE A 540
None
0.71A 5p9iA-4xi2A:
41.2
5p9iA-4xi2A:
94.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
9 / 12 VAL A 416
LYS A 430
MET A 449
ILE A 472
GLY A 480
ASN A 484
LEU A 528
SER A 538
PHE A 540
None
0.90A 5p9iA-4xi2A:
41.2
5p9iA-4xi2A:
94.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 5 LEU A 408
TYR A 476
MET A 477
CYH A 481
ASP A 539
None
0.62A 5p9iA-4xi2A:
41.2
5p9iA-4xi2A:
94.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
3 / 3 HIS A 519
SER A 538
ARG A 525
None
0.96A 5u63A-4xi2A:
undetectable
5u63A-4xi2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 GLU A 567
LEU A 569
ILE A 610
ARG A 615
VAL A 585
None
1.43A 5vlmE-4xi2A:
undetectable
5vlmE-4xi2A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 LEU A 408
GLY A 409
VAL A 416
ALA A 428
MET A 449
CYH A 481
LEU A 528
ASP A 539
None
0.98A 5yu9A-4xi2A:
29.9
5yu9A-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 LEU A 408
GLY A 409
VAL A 416
LYS A 430
MET A 449
CYH A 481
ASP A 539
None
1.09A 5yu9A-4xi2A:
29.9
5yu9A-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 GLY A 409
VAL A 416
ALA A 428
MET A 449
CYH A 481
LEU A 528
ASP A 539
None
0.88A 5yu9B-4xi2A:
26.7
5yu9B-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 VAL A 416
ALA A 428
MET A 449
GLY A 480
CYH A 481
ASP A 539
None
0.82A 5yu9C-4xi2A:
29.9
5yu9C-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 VAL A 416
ALA A 428
MET A 449
GLY A 480
CYH A 481
LEU A 528
ASP A 539
LEU A 542
None
0.75A 5yu9D-4xi2A:
25.7
5yu9D-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
6 / 12 VAL A 416
LYS A 430
MET A 449
CYH A 481
ASP A 539
LEU A 542
None
1.04A 5yu9D-4xi2A:
25.7
5yu9D-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
3 / 3 TYR A 476
LEU A 528
ASP A 539
None
0.60A 5zv2B-4xi2A:
30.0
5zv2B-4xi2A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
7 / 12 VAL A 416
ALA A 428
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
None
0.73A 6bsdA-4xi2A:
25.3
6bsdA-4xi2A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 LEU A 542
GLY A 541
SER A 564
VAL A 568
ARG A 544
None
1.33A 6bxlB-4xi2A:
undetectable
6bxlB-4xi2A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 LEU A 542
GLY A 541
SER A 564
VAL A 568
ARG A 544
None
1.22A 6bxmA-4xi2A:
undetectable
6bxmA-4xi2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
5 / 12 LEU A 542
GLY A 541
SER A 564
VAL A 568
ARG A 544
None
1.35A 6bxnB-4xi2A:
undetectable
6bxnB-4xi2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
4 / 8 GLY A 389
GLN A 459
THR A 387
SER A 394
None
0.86A 6eqpA-4xi2A:
undetectable
6eqpA-4xi2A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus
musculus)
8 / 12 VAL A 416
ALA A 428
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
SER A 538
None
0.67A 6fnmA-4xi2A:
30.7
6fnmA-4xi2A:
26.68