SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4xi5 FAB-94 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 THR D 168
VAL D 171
VAL D 190
SER D 188
ASN D 205
 None
 1.20A 3nyaA-4xi5D:
undetectable		 3nyaA-4xi5D:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4xi5 FAB-94 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 HIS D  35
VAL D  37
TRP D 111
HIS D 103
TYR D 106
 None
 1.35A 3wfhA-4xi5D:
19.2
3wfhB-4xi5D:
15.2		 3wfhA-4xi5D:
49.38
3wfhB-4xi5D:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4xi5 FAB-94 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 HIS D  35
VAL D  37
TRP D 111
HIS D 103
TYR D 106
 None
 1.36A 3whxA-4xi5D:
19.2
3whxB-4xi5D:
15.3		 3whxA-4xi5D:
49.18
3whxB-4xi5D:
27.56