SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xi8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E00_A_9CRA7223_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4xi8	BARTONELLA EFFECTOR PROTEIN (BEP) SUBSTRATE OF VIRB T4SS (Bartonella clarridgeiae)	5 / 12	ILE A 163 ALA A 166 ALA A 167 VAL A 138 ILE A 116	None	1.08A	3e00A-4xi8A: undetectable	3e00A-4xi8A: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LNW_A_T3A501_2 (THYROID HORMONE RECEPTOR ALPHA)	4xi8	BARTONELLA EFFECTOR PROTEIN (BEP) SUBSTRATE OF VIRB T4SS (Bartonella clarridgeiae)	3 / 3	ILE A 140 MET A 181 ARG A 180	None	0.85A	4lnwA-4xi8A: undetectable	4lnwA-4xi8A: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LNX_A_T3A502_2 (THYROID HORMONE RECEPTOR ALPHA)	4xi8	BARTONELLA EFFECTOR PROTEIN (BEP) SUBSTRATE OF VIRB T4SS (Bartonella clarridgeiae)	3 / 3	ILE A 140 MET A 181 ARG A 180	None	0.86A	4lnxA-4xi8A: undetectable	4lnxA-4xi8A: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_A_X2NA590_1 (CYP51 VARIANT1)	4xi8	BARTONELLA EFFECTOR PROTEIN (BEP) SUBSTRATE OF VIRB T4SS (Bartonella clarridgeiae)	5 / 12	ALA A 82 TYR A 75 PHE A 207 ILE A 210 PHE A 139	None	1.19A	5fsaA-4xi8A: undetectable	5fsaA-4xi8A: 18.55

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3E00_A_9CRA7223_1","RETINOIC ACID RECEPTOR RXR-ALPHA","4xi8","BARTONELLA EFFECTOR PROTEIN (BEP) SUBSTRATE OF VIRB T4SS","Bartonella clarridgeiae",5,"ILE A 163;ALA A 166;ALA A 167;VAL A 138;ILE A 116","None","1.08A","3e00A-4xi8A:undetectable","3e00A-4xi8A:20.98"],["4LNW_A_T3A501_2","THYROID HORMONE RECEPTOR ALPHA","4xi8","BARTONELLA EFFECTOR PROTEIN (BEP) SUBSTRATE OF VIRB T4SS","Bartonella clarridgeiae",3,"ILE A 140;MET A 181;ARG A 180","None","0.85A","4lnwA-4xi8A:undetectable","4lnwA-4xi8A:22.97"],["4LNX_A_T3A502_2","THYROID HORMONE RECEPTOR ALPHA","4xi8","BARTONELLA EFFECTOR PROTEIN (BEP) SUBSTRATE OF VIRB T4SS","Bartonella clarridgeiae",3,"ILE A 140;MET A 181;ARG A 180","None","0.86A","4lnxA-4xi8A:undetectable","4lnxA-4xi8A:22.97"],["5FSA_A_X2NA590_1","CYP51 VARIANT1","4xi8","BARTONELLA EFFECTOR PROTEIN (BEP) SUBSTRATE OF VIRB T4SS","Bartonella clarridgeiae",5,"ALA A  82;TYR A  75;PHE A 207;ILE A 210;PHE A 139","None","1.19A","5fsaA-4xi8A:undetectable","5fsaA-4xi8A:18.55"]]