SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 11 GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 0.87A 1ohrA-4xibA:
undetectable		 1ohrA-4xibA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		3 / 3 HIS A 122
HIS A 118
HIS A 119
 ZN  A 402 (-3.1A)
ZN  A 402 (-3.2A)
None
 0.66A 1rkyA-4xibA:
undetectable		 1rkyA-4xibA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.40A 2idwB-4xibA:
undetectable		 2idwB-4xibA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 11 GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 0.83A 2nnpA-4xibA:
undetectable		 2nnpA-4xibA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 11 ALA A 155
ALA A 153
GLY A 224
GLY A 150
ILE A 151
 None
 1.08A 2x1lA-4xibA:
undetectable		 2x1lA-4xibA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 11 ALA A 155
ALA A 153
GLY A 224
GLY A 150
ILE A 151
 None
 1.10A 2x1lC-4xibA:
undetectable		 2x1lC-4xibA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		3 / 3 VAL A 161
TRP A 165
TRP A 163
 None
 1.20A 2xdcC-4xibA:
undetectable
2xdcD-4xibA:
undetectable		 2xdcC-4xibA:
6.49
2xdcD-4xibA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.50A 3ekpD-4xibA:
undetectable		 3ekpD-4xibA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.35A 3ekvA-4xibA:
undetectable		 3ekvA-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 11 GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 0.95A 3ekxA-4xibA:
undetectable		 3ekxA-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 8 GLY A  15
ALA A  16
ASP A  72
THR A 128
ILE A  70
 None
None
None
SO4  A 403 (-3.1A)
None
 1.16A 3el0A-4xibA:
undetectable		 3el0A-4xibA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 12 GLY A  15
ALA A  16
ILE A  94
THR A 129
PRO A 130
 None
 0.94A 3el5B-4xibA:
undetectable		 3el5B-4xibA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.46A 3em3A-4xibA:
undetectable		 3em3A-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 1.39A 3em3A-4xibA:
undetectable		 3em3A-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		4 / 7 VAL A  36
ILE A 181
THR A 179
GLY A 150
 None
 1.01A 3gssB-4xibA:
undetectable		 3gssB-4xibA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		3 / 3 ASN A 253
ASP A 116
ARG A 149
 None
 0.74A 3k13A-4xibA:
undetectable		 3k13A-4xibA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 12 GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 0.92A 3nduA-4xibA:
undetectable		 3nduA-4xibA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 11 GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 0.89A 3ndxB-4xibA:
undetectable		 3ndxB-4xibA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 11 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.47A 3nu3B-4xibA:
undetectable		 3nu3B-4xibA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.45A 3nu4B-4xibA:
undetectable		 3nu4B-4xibA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.48A 3nujB-4xibA:
undetectable		 3nujB-4xibA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.46A 3nuoB-4xibA:
undetectable		 3nuoB-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.46A 3oxvA-4xibA:
undetectable		 3oxvA-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.41A 3oxvC-4xibA:
undetectable		 3oxvC-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 1.45A 3oxwC-4xibA:
undetectable		 3oxwC-4xibA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 1.40A 3oy4B-4xibA:
undetectable		 3oy4B-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 12 GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 0.88A 3pwmB-4xibA:
undetectable		 3pwmB-4xibA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		3 / 3 VAL A 161
TRP A 165
TRP A 163
 None
 1.14A 3zq8A-4xibA:
undetectable
3zq8B-4xibA:
undetectable		 3zq8A-4xibA:
6.49
3zq8B-4xibA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 12 VAL A  19
ARG A  20
ILE A 146
PHE A 226
HIS A 230
 None
 1.39A 4c49D-4xibA:
undetectable		 4c49D-4xibA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 1.38A 4dqbB-4xibA:
undetectable		 4dqbB-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.41A 4dqfB-4xibA:
undetectable		 4dqfB-4xibA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		4 / 8 PHE A  42
GLY A  13
ILE A  70
THR A  76
 None
 0.82A 4em2A-4xibA:
undetectable		 4em2A-4xibA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.47A 4ll3B-4xibA:
undetectable		 4ll3B-4xibA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 1.40A 4q1wA-4xibA:
undetectable		 4q1wA-4xibA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 11 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 1.39A 4q1xA-4xibA:
undetectable		 4q1xA-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 10 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
VAL A 207
 None
 1.38A 4q1yA-4xibA:
undetectable		 4q1yA-4xibA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.40A 4rvjB-4xibA:
undetectable		 4rvjB-4xibA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		6 / 9 LEU A 215
GLY A 154
ALA A 155
ASP A 220
GLY A 223
ILE A 151
 None
 1.41A 4rvjD-4xibA:
undetectable		 4rvjD-4xibA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		4 / 4 VAL A 325
ALA A 380
ASN A 377
GLN A 336
 None
 1.42A 4zgfA-4xibA:
undetectable		 4zgfA-4xibA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		3 / 3 GLY A 171
ASP A 169
ASN A 203
 None
 0.59A 5jglA-4xibA:
undetectable		 5jglA-4xibA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens) 		5 / 9 SER A 213
VAL A  49
SER A  41
VAL A  51
GLY A  15
 None
 1.23A 6bklA-4xibA:
undetectable
6bklB-4xibA:
undetectable
6bklC-4xibA:
undetectable
6bklD-4xibA:
undetectable		 6bklA-4xibA:
7.19
6bklB-4xibA:
7.19
6bklC-4xibA:
7.19
6bklD-4xibA:
7.19