SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xij'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		5 / 10 GLU A 233
ALA A 189
LEU A 114
ALA A 188
GLY A 118
 None
 1.24A 1mjqG-4xijA:
undetectable
1mjqH-4xijA:
undetectable		 1mjqG-4xijA:
18.50
1mjqH-4xijA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		5 / 12 ALA A 117
LEU A 137
ILE A 124
LEU A 205
VAL A 211
 None
 1.03A 4kfjB-4xijA:
undetectable		 4kfjB-4xijA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		5 / 12 GLY A  12
GLY A  68
LEU A  51
LEU A  48
GLU A  39
 None
 0.98A 4lg1B-4xijA:
5.0		 4lg1B-4xijA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		4 / 7 GLY A 115
ARG A 210
ALA A 113
ILE A 235
 None
 0.65A 4txnA-4xijA:
2.7		 4txnA-4xijA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		4 / 7 GLY A 115
ARG A 210
ALA A 113
ILE A 235
 None
 0.63A 4txnB-4xijA:
undetectable		 4txnB-4xijA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		4 / 7 GLY A 115
ARG A 210
ALA A 113
ILE A 235
 None
 0.64A 4txnC-4xijA:
undetectable		 4txnC-4xijA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		4 / 7 GLY A 115
ARG A 210
ALA A 113
ILE A 235
 None
 0.65A 4txnD-4xijA:
undetectable		 4txnD-4xijA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		4 / 6 ASP A 106
ALA A  83
THR A 105
THR A  91
 SO4  A 304 (-2.7A)
None
None
None
 1.49A 4z4cA-4xijA:
undetectable		 4z4cA-4xijA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		5 / 12 VAL A 190
VAL A 142
GLY A 118
ALA A 117
LEU A 114
 None
 1.13A 5iktA-4xijA:
undetectable		 5iktA-4xijA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4xij SHIKIMATE
5-DEHYDROGENASE
(Mycolicibacteriu
m
fortuitum) 		5 / 12 GLY A 175
GLY A 176
LEU A 179
GLY A 127
PRO A 131
 None
None
None
EDO  A 303 ( 3.7A)
None
 1.10A 6gngB-4xijA:
5.2		 6gngB-4xijA:
20.39