SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xin'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		4 / 5 ALA A 118
ALA A 104
GLN A  72
VAL A  69
 None
 0.93A 2nyrB-4xinA:
undetectable		 2nyrB-4xinA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		4 / 6 PHE A  98
MET A  91
ILE A  44
ARG A  42
 None
 1.34A 4mk4B-4xinA:
undetectable		 4mk4B-4xinA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 11 SER A  20
THR A  94
SER A  16
ALA A  13
THR A  18
 None
 1.44A 4qvyV-4xinA:
undetectable
4qvyb-4xinA:
undetectable		 4qvyV-4xinA:
20.26
4qvyb-4xinA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 11 SER A  20
THR A  94
SER A  16
ALA A  13
THR A  18
 None
 1.45A 4qvyH-4xinA:
undetectable
4qvyN-4xinA:
undetectable		 4qvyH-4xinA:
20.26
4qvyN-4xinA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 11 SER A  20
THR A  94
SER A  16
ALA A  13
THR A  18
 None
 1.45A 5l5fV-4xinA:
undetectable
5l5fb-4xinA:
undetectable		 5l5fV-4xinA:
20.26
5l5fb-4xinA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 12 ILE A 100
VAL A  33
ALA A  89
MET A  91
VAL A  57
 None
 1.09A 5n0rA-4xinA:
undetectable		 5n0rA-4xinA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 12 ILE A 100
VAL A  33
ALA A  89
MET A  91
VAL A  57
 None
 1.09A 5n0tA-4xinA:
undetectable		 5n0tA-4xinA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 12 ILE A 100
VAL A  33
ALA A  89
MET A  91
VAL A  57
 None
 1.07A 5n0wA-4xinA:
undetectable		 5n0wA-4xinA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 12 ILE A 100
VAL A  33
ALA A  89
MET A  91
VAL A  57
 None
 1.06A 5n0xA-4xinA:
undetectable		 5n0xA-4xinA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 12 ILE A 100
VAL A  33
ALA A  89
MET A  91
VAL A  57
 None
 1.05A 5n0xB-4xinA:
undetectable		 5n0xB-4xinA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4xin LPQH ORTHOLOGUE
(Mycobacterium
avium) 		5 / 12 ILE A 100
VAL A  33
ALA A  89
MET A  91
VAL A  57
 None
 1.06A 5n4iA-4xinA:
undetectable		 5n4iA-4xinA:
15.37