SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xiv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 9 ASN A 409
ASP A 449
ARG A 452
ILE A 454
THR A 531
ACP  A 601 (-2.9A)
ACP  A 601 (-3.8A)
None
ACP  A 601 ( 4.6A)
ACP  A 601 (-3.9A)
0.90A 1aj6A-4xivA:
3.3
1aj6A-4xivA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 ASN A 409
ASP A 449
ARG A 452
ILE A 454
THR A 531
ACP  A 601 (-2.9A)
ACP  A 601 (-3.8A)
None
ACP  A 601 ( 4.6A)
ACP  A 601 (-3.9A)
0.88A 1kijB-4xivA:
5.6
1kijB-4xivA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
4 / 7 PHE A 362
ALA A 436
ILE A 399
ILE A 535
None
0.95A 1oniD-4xivA:
undetectable
1oniF-4xivA:
undetectable
1oniD-4xivA:
20.24
1oniF-4xivA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 GLU A 416
GLY A 453
VAL A 369
GLY A 430
ILE A 415
None
ACP  A 601 (-4.7A)
None
None
None
1.21A 3k13A-4xivA:
undetectable
3k13A-4xivA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 GLU A 416
GLY A 453
VAL A 369
GLY A 430
ILE A 415
None
ACP  A 601 (-4.7A)
None
None
None
1.22A 3k13B-4xivA:
undetectable
3k13B-4xivA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 GLU A 416
GLY A 530
VAL A 369
GLY A 430
ILE A 415
None
1.19A 3k13B-4xivA:
undetectable
3k13B-4xivA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 GLU A 416
GLY A 453
VAL A 369
GLY A 430
ILE A 415
None
ACP  A 601 (-4.7A)
None
None
None
1.22A 3k13C-4xivA:
undetectable
3k13C-4xivA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 GLU A 416
GLY A 530
VAL A 369
GLY A 430
ILE A 415
None
1.18A 3k13C-4xivA:
undetectable
3k13C-4xivA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 ILE A 358
THR A 389
VAL A 396
ILE A 399
ILE A 445
None
1.19A 3kpbA-4xivA:
undetectable
3kpbA-4xivA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 GLY A 414
ARG A 452
GLY A 530
ARG A 408
ASP A 412
ACP  A 601 (-3.4A)
None
None
None
ACP  A 601 (-3.7A)
1.19A 3tkaA-4xivA:
undetectable
3tkaA-4xivA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 GLY A 414
ALA A 410
GLY A 451
LEU A 432
GLY A 530
ACP  A 601 (-3.4A)
ACP  A 601 ( 4.3A)
None
None
None
0.86A 4o3fA-4xivA:
undetectable
4o3fA-4xivA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 ASN A 409
ASP A 449
ARG A 452
ILE A 454
THR A 531
ACP  A 601 (-2.9A)
ACP  A 601 (-3.8A)
None
ACP  A 601 ( 4.6A)
ACP  A 601 (-3.9A)
1.03A 4uroD-4xivA:
3.7
4uroD-4xivA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 VAL A 533
ILE A 454
VAL A 488
PHE A 487
MET A 507
None
ACP  A 601 ( 4.6A)
None
None
ACP  A 601 (-4.2A)
0.96A 4y0pA-4xivA:
undetectable
4y0pA-4xivA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
4 / 6 ILE A 415
ARG A 421
ILE A 429
GLU A 379
None
1.08A 4zzcA-4xivA:
4.1
4zzcB-4xivA:
3.6
4zzcA-4xivA:
20.25
4zzcB-4xivA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
3 / 3 LYS A 511
ASP A 508
ILE A 399
None
0.84A 5kc4E-4xivA:
undetectable
5kc4E-4xivA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima)
5 / 12 GLU A 416
GLY A 453
VAL A 369
GLY A 430
ILE A 415
None
ACP  A 601 (-4.7A)
None
None
None
1.16A 5vooD-4xivA:
undetectable
5vooD-4xivA:
23.72