SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xjv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN
(Homo
sapiens) 		5 / 12 ALA A 111
GLU A 121
LEU A 112
LEU A 200
LEU A 127
 None
 1.12A 2jfaA-4xjvA:
undetectable		 2jfaA-4xjvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN
(Homo
sapiens) 		5 / 12 ALA A 111
GLU A 121
LEU A 112
LEU A 200
LEU A 127
 None
 1.11A 2jfaB-4xjvA:
undetectable		 2jfaB-4xjvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN
(Homo
sapiens) 		5 / 12 ALA A 111
GLU A 121
LEU A 112
LEU A 200
LEU A 127
 None
 1.14A 2qxsA-4xjvA:
undetectable		 2qxsA-4xjvA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN
(Homo
sapiens) 		4 / 6 ALA A 107
ILE A 106
HIS A  56
VAL A  82
 None
 1.03A 3nneG-4xjvA:
undetectable		 3nneG-4xjvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN
(Homo
sapiens) 		3 / 3 LYS A  77
ARG A 109
LYS A 143
 None
 1.50A 3okxA-4xjvA:
undetectable		 3okxA-4xjvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN
(Homo
sapiens) 		3 / 3 TYR A 105
MET A 102
ILE A 179
 None
 0.87A 4c8bB-4xjvA:
undetectable		 4c8bB-4xjvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN
(Homo
sapiens) 		4 / 5 PHE A  32
LEU A 114
GLY A 113
ILE A 106
 None
 0.96A 5ik1A-4xjvA:
undetectable		 5ik1A-4xjvA:
19.80