SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xjx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 4xjx HSDR
(Escherichia
coli) 		4 / 6 GLN A 384
CYH A 410
ASP A 338
VAL A 336
 None
 1.47A 1ekjG-4xjxA:
undetectable
1ekjH-4xjxA:
undetectable		 1ekjG-4xjxA:
12.77
1ekjH-4xjxA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4xjx HSDR
(Escherichia
coli) 		4 / 8 GLN A 199
LEU A 200
LYS A 319
LEU A 129
 None
 1.02A 1hk2A-4xjxA:
undetectable		 1hk2A-4xjxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4xjx HSDR
(Escherichia
coli) 		5 / 10 LEU A 521
THR A 517
ILE A 516
THR A 578
ILE A 654
 None
 1.42A 1i18A-4xjxA:
undetectable
1i18B-4xjxA:
undetectable		 1i18A-4xjxA:
6.08
1i18B-4xjxA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4xjx HSDR
(Escherichia
coli) 		5 / 10 THR A 578
ILE A 654
LEU A 521
THR A 517
ILE A 516
 None
 1.40A 1i18A-4xjxA:
undetectable
1i18B-4xjxA:
undetectable		 1i18A-4xjxA:
6.08
1i18B-4xjxA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 ASP A 777
PHE A 763
ARG A 762
 None
 0.80A 2a3aA-4xjxA:
undetectable		 2a3aA-4xjxA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4xjx HSDR
(Escherichia
coli) 		4 / 7 LEU A 781
PHE A 778
GLY A 783
ILE A 791
 None
 1.09A 2bdmA-4xjxA:
undetectable		 2bdmA-4xjxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4xjx HSDR
(Escherichia
coli) 		5 / 11 SER A 311
ASP A 343
THR A 309
GLY A 310
PHE A 663
 ATP  A1102 (-4.4A)
None
ATP  A1102 (-3.7A)
ATP  A1102 (-3.2A)
None
 1.45A 2hmaA-4xjxA:
undetectable		 2hmaA-4xjxA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4xjx HSDR
(Escherichia
coli) 		5 / 12 ILE A 579
TYR A 619
LEU A 660
ALA A 577
ASP A 341
 None
 1.33A 2iyfB-4xjxA:
undetectable		 2iyfB-4xjxA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4xjx HSDR
(Escherichia
coli) 		4 / 7 THR A 435
ILE A 439
ASN A 443
PHE A 440
 None
 1.18A 2jc9A-4xjxA:
undetectable		 2jc9A-4xjxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4xjx HSDR
(Escherichia
coli) 		5 / 11 LEU A  68
LEU A  89
SER A  58
LEU A  61
LEU A 159
 None
 1.09A 2xn5A-4xjxA:
undetectable		 2xn5A-4xjxA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4xjx HSDR
(Escherichia
coli) 		4 / 8 THR A 661
LEU A 677
GLU A 597
SER A 595
 None
 1.05A 2zw9A-4xjxA:
2.4		 2zw9A-4xjxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4xjx HSDR
(Escherichia
coli) 		4 / 6 GLN A 761
LEU A 759
GLU A 758
LEU A 781
 None
 0.80A 3h5gA-4xjxA:
undetectable
3h5gC-4xjxA:
undetectable		 3h5gA-4xjxA:
2.61
3h5gC-4xjxA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 ASP A 605
PHE A 582
SER A 546
 None
 1.00A 3i5uB-4xjxA:
2.7		 3i5uB-4xjxA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 THR A 491
LYS A 527
GLU A 490
 None
 0.94A 3ijdB-4xjxA:
undetectable		 3ijdB-4xjxA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 SER A 545
ASP A 674
ASP A 548
 None
 0.85A 3iv6A-4xjxA:
2.4		 3iv6A-4xjxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 SER A 545
ASP A 674
ASP A 548
 None
 0.84A 3iv6C-4xjxA:
undetectable		 3iv6C-4xjxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 LYS A 749
ILE A 173
PHE A 177
 None
 1.00A 3j7zS-4xjxA:
undetectable
3j7za-4xjxA:
undetectable		 3j7zS-4xjxA:
7.68
3j7za-4xjxA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4xjx HSDR
(Escherichia
coli) 		5 / 12 ARG A 412
GLY A 446
GLY A 592
LEU A 718
SER A 711
 None
 1.07A 3kkzB-4xjxA:
2.3		 3kkzB-4xjxA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 ALA A 365
ARG A 369
LYS A 373
 None
 0.91A 3kp5B-4xjxA:
undetectable		 3kp5B-4xjxA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 ASN A 157
ASN A  63
GLU A  66
 None
 0.88A 3kpdC-4xjxA:
undetectable		 3kpdC-4xjxA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 HIS A 165
PHE A 243
PHE A 248
 None
 0.65A 3lk0D-4xjxA:
undetectable		 3lk0D-4xjxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 TYR A  20
ASP A  43
ASP A 242
 None
 0.53A 3r24A-4xjxA:
undetectable		 3r24A-4xjxA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4xjx HSDR
(Escherichia
coli) 		4 / 8 PHE A 557
GLU A 562
GLU A 563
LEU A 521
 None
 1.07A 3rqwC-4xjxA:
2.3
3rqwD-4xjxA:
2.4		 3rqwC-4xjxA:
15.60
3rqwD-4xjxA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4xjx HSDR
(Escherichia
coli) 		4 / 8 GLU A 562
GLU A 563
LEU A 521
PHE A 557
 None
 1.06A 3rqwF-4xjxA:
undetectable
3rqwJ-4xjxA:
undetectable		 3rqwF-4xjxA:
15.60
3rqwJ-4xjxA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4xjx HSDR
(Escherichia
coli) 		4 / 4 LEU A 653
ALA A 642
PHE A 663
ASN A 647
 None
 1.48A 3vasA-4xjxA:
undetectable		 3vasA-4xjxA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4xjx HSDR
(Escherichia
coli) 		4 / 5 ASP A 881
THR A 696
LEU A 882
GLU A 879
 None
 1.41A 4a3pA-4xjxA:
undetectable		 4a3pA-4xjxA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 HIS A 181
GLU A 186
ASN A 214
 None
 0.97A 4bupB-4xjxA:
undetectable		 4bupB-4xjxA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 4xjx HSDR
(Escherichia
coli) 		4 / 7 LEU A 161
ILE A  52
ILE A 137
VAL A  54
 None
 0.81A 4ojbA-4xjxA:
undetectable		 4ojbA-4xjxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4xjx HSDR
(Escherichia
coli) 		4 / 4 LEU A 759
VAL A 755
GLU A 758
ARG A 750
 None
 1.08A 4ww7A-4xjxA:
undetectable		 4ww7A-4xjxA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xjx HSDR
(Escherichia
coli) 		5 / 12 ILE A 439
PHE A 415
GLY A 416
GLY A 446
VAL A 453
 None
 0.97A 5i73A-4xjxA:
2.5		 5i73A-4xjxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4xjx HSDR
(Escherichia
coli) 		5 / 12 SER A 261
ASN A 157
VAL A 134
VAL A 256
LEU A 254
 None
 1.17A 5kocB-4xjxA:
undetectable		 5kocB-4xjxA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xjx HSDR
(Escherichia
coli) 		4 / 4 GLN A 249
THR A 252
THR A 209
LEU A  40
 None
 1.48A 5m5kC-4xjxA:
3.0		 5m5kC-4xjxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xjx HSDR
(Escherichia
coli) 		4 / 4 GLN A 249
THR A 252
THR A 209
LEU A  40
 None
 1.47A 5m66B-4xjxA:
2.7		 5m66B-4xjxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4xjx HSDR
(Escherichia
coli) 		4 / 5 LEU A 253
LEU A 257
MET A 130
GLN A  47
 None
 1.16A 5uc3A-4xjxA:
undetectable		 5uc3A-4xjxA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 HIS A 181
GLU A 186
ASN A 214
 None
 1.00A 5wbvA-4xjxA:
undetectable		 5wbvA-4xjxA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4xjx HSDR
(Escherichia
coli) 		3 / 3 HIS A 181
GLU A 186
ASN A 214
 None
 1.01A 5wbvB-4xjxA:
undetectable		 5wbvB-4xjxA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4xjx HSDR
(Escherichia
coli) 		5 / 12 ILE A 137
PHE A 195
LEU A 123
PRO A 160
LEU A 155
 None
 1.12A 5xxiA-4xjxA:
undetectable		 5xxiA-4xjxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4xjx HSDR
(Escherichia
coli) 		5 / 12 SER A 261
VAL A 202
THR A 209
LEU A 161
LEU A 254
 None
 1.34A 6a93B-4xjxA:
undetectable		 6a93B-4xjxA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 4xjx HSDR
(Escherichia
coli) 		4 / 4 GLN A 249
THR A 252
THR A 209
LEU A  40
 None
 1.49A 6f3mB-4xjxA:
2.6		 6f3mB-4xjxA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4xjx HSDR
(Escherichia
coli) 		4 / 5 THR A 346
THR A 661
HIS A 411
GLY A 360
 None
 1.08A 6gbnC-4xjxA:
2.7		 6gbnC-4xjxA:
17.43