SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 198
ILE A 337
SER A 295
ASN A 151
 LLP  A 197 ( 4.2A)
None
None
None
 1.20A 1h7xA-4xk1A:
undetectable		 1h7xA-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 198
ILE A 337
SER A 295
ASN A 151
 LLP  A 197 ( 4.2A)
None
None
None
 1.21A 1h7xB-4xk1A:
undetectable		 1h7xB-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 198
ILE A 337
SER A 295
ASN A 151
 LLP  A 197 ( 4.2A)
None
None
None
 1.21A 1h7xC-4xk1A:
undetectable		 1h7xC-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 198
ILE A 337
SER A 295
ASN A 151
 LLP  A 197 ( 4.2A)
None
None
None
 1.21A 1h7xD-4xk1A:
undetectable		 1h7xD-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 338
SER A 336
THR A 153
ASN A 151
 LLP  A 197 ( 4.0A)
None
LLP  A 197 ( 3.0A)
None
 1.38A 1yvpA-4xk1A:
undetectable		 1yvpA-4xk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 PRO A  85
TYR A 114
GLY A 115
THR A 116
 None
 1.10A 3ib0A-4xk1A:
undetectable		 3ib0A-4xk1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  71
GLY A 194
ALA A  77
ILE A  84
 None
LLP  A 197 ( 4.5A)
LLP  A 197 ( 3.5A)
None
 0.81A 3jusA-4xk1A:
undetectable		 3jusA-4xk1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  71
GLY A 194
ALA A  77
ILE A  84
 None
LLP  A 197 ( 4.5A)
LLP  A 197 ( 3.5A)
None
 0.81A 3jusA-4xk1A:
undetectable		 3jusA-4xk1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 PRO A 163
TYR A 148
ILE A  98
VAL A 146
THR A 165
 None
 1.46A 3p4wA-4xk1A:
undetectable		 3p4wA-4xk1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ASN A   7
ALA A  14
TYR A 338
ALA A  10
 None
None
LLP  A 197 ( 4.0A)
None
 1.36A 3twpD-4xk1A:
undetectable		 3twpD-4xk1A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 332
GLY A 331
ILE A 279
THR A 278
LEU A 275
 None
 0.78A 4n49A-4xk1A:
undetectable		 4n49A-4xk1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 200
PRO A 201
GLN A 196
 None
None
LLP  A 197 ( 3.1A)
 0.57A 4oltB-4xk1A:
undetectable		 4oltB-4xk1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 132
LEU A 139
SER A 122
 None
 0.74A 5fsaB-4xk1A:
undetectable		 5fsaB-4xk1A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ILE A  64
LEU A 170
GLY A 189
PHE A 188
 None
 0.93A 5kmdC-4xk1A:
undetectable
5kmdD-4xk1A:
undetectable		 5kmdC-4xk1A:
22.66
5kmdD-4xk1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 PRO A 240
LEU A 204
ILE A 199
PHE A  72
PHE A 252
 None
 1.20A 5m0oA-4xk1A:
undetectable		 5m0oA-4xk1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 PRO A 163
TYR A 148
ILE A  98
VAL A 146
THR A 165
 None
 1.35A 5mzrA-4xk1A:
undetectable		 5mzrA-4xk1A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 PRO A 163
TYR A 148
ILE A  98
VAL A 146
THR A 165
 None
 1.37A 5mzrC-4xk1A:
undetectable		 5mzrC-4xk1A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 PRO A 163
TYR A 148
ILE A  98
VAL A 146
THR A 165
 None
 1.41A 5mzrD-4xk1A:
undetectable		 5mzrD-4xk1A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 196
GLY A 194
VAL A 207
SER A  78
 LLP  A 197 ( 3.1A)
LLP  A 197 ( 4.5A)
None
LLP  A 197 ( 2.4A)
 1.05A 6hu9S-4xk1A:
undetectable
6hu9q-4xk1A:
undetectable		 6hu9S-4xk1A:
13.11
6hu9q-4xk1A:
17.76