SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4xk8 CHLOROPHYLL A-B
BINDING PROTEIN 3,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 11 ARG 3 226
LEU 3  62
LEU 3  51
ALA 3  54
PHE 3  72
 CLA  3 302 ( 3.4A)
CLA  3 302 (-4.0A)
None
None
XAT  3 317 ( 4.3A)
 1.37A 1cmaA-4xk83:
undetectable
1cmaB-4xk83:
undetectable		 1cmaA-4xk83:
14.35
1cmaB-4xk83:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4xk8 CHLOROPHYLL A-B
BINDING PROTEIN 3,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 10 ARG 3 226
LEU 3  62
LEU 3  51
ALA 3  54
PHE 3  72
 CLA  3 302 ( 3.4A)
CLA  3 302 (-4.0A)
None
None
XAT  3 317 ( 4.3A)
 1.43A 1cmcA-4xk83:
undetectable
1cmcB-4xk83:
undetectable		 1cmcA-4xk83:
14.35
1cmcB-4xk83:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		4 / 7 THR L 136
LEU L  46
GLY L  49
LEU L 126
 None
 1.03A 1gtiD-4xk8L:
undetectable		 1gtiD-4xk8L:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		3 / 3 SER L 109
GLU L 122
ASP L 124
 None
 0.85A 2zthA-4xk8L:
undetectable		 2zthA-4xk8L:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		3 / 3 SER L 109
GLU L 122
ASP L 124
 None
 0.84A 3bwmA-4xk8L:
undetectable		 3bwmA-4xk8L:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		3 / 3 SER L 109
GLU L 122
ASP L 124
 None
 0.85A 3bwyA-4xk8L:
undetectable		 3bwyA-4xk8L:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		5 / 12 GLY L  85
ALA L  83
ILE L 144
LEU L  60
VAL L 147
 None
BCR  L 201 ( 3.9A)
None
None
None
 0.87A 4azsA-4xk8L:
undetectable		 4azsA-4xk8L:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		5 / 12 GLY L  85
ALA L  83
ILE L 144
LEU L  60
VAL L 147
 None
BCR  L 201 ( 3.9A)
None
None
None
 0.89A 4aztA-4xk8L:
undetectable		 4aztA-4xk8L:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		5 / 12 GLY L  85
ALA L  83
ILE L 144
LEU L  60
VAL L 147
 None
BCR  L 201 ( 3.9A)
None
None
None
 0.87A 4azvA-4xk8L:
undetectable		 4azvA-4xk8L:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		5 / 12 GLY L  85
ALA L  83
ILE L 144
LEU L  60
VAL L 147
 None
BCR  L 201 ( 3.9A)
None
None
None
 0.89A 4azwA-4xk8L:
undetectable		 4azwA-4xk8L:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4xk8 CHLOROPHYLL A-B
BINDING PROTEIN P4,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 12 LEU 4 177
VAL 4 166
SER 4 165
LEU 4  96
VAL 4  97
 CHL  4 615 ( 4.4A)
None
None
None
CLA  4 608 (-4.4A)
 1.28A 4ib4A-4xk84:
undetectable		 4ib4A-4xk84:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		5 / 12 GLY L  85
ALA L  83
ILE L 144
LEU L  60
VAL L 147
 None
BCR  L 201 ( 3.9A)
None
None
None
 1.05A 4uw0A-4xk8L:
undetectable		 4uw0A-4xk8L:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		3 / 3 SER L 109
GLU L 122
ASP L 124
 None
 0.83A 4xudA-4xk8L:
undetectable		 4xudA-4xk8L:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		5 / 7 GLY L  49
GLY L 142
SER L 145
GLY L 143
VAL L  52
 None
None
BCR  L 206 (-3.2A)
None
CLA  L 203 (-3.3A)
 1.32A 5izjB-4xk8L:
undetectable		 5izjB-4xk8L:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 4xk8 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT III,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ARG F 154
HIS F 155
LEU F  81
PRO F  83
 None
 1.46A 5syjA-4xk8F:
2.3		 5syjA-4xk8F:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 4xk8 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT III,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ARG F 154
HIS F 155
LEU F  81
PRO F  83
 None
 1.46A 5syjB-4xk8F:
2.7		 5syjB-4xk8F:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		4 / 6 THR L  41
ARG L  48
PRO L 112
GLN L 127
 None
 1.00A 6ef6A-4xk8L:
undetectable		 6ef6A-4xk8L:
17.00