SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 205
LEU A 200
THR A 112
ILE A 146
PHE A 160
 None
 1.48A 1p93B-4xkbA:
undetectable		 1p93B-4xkbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 TRP A 167
LEU A 166
LYS A 180
 None
 1.47A 1yajK-4xkbA:
undetectable		 1yajK-4xkbA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 ASP A 114
ARG A 127
LEU A 130
GLU A 134
 None
 1.03A 2cdqB-4xkbA:
undetectable		 2cdqB-4xkbA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLN A 103
PHE A 105
PHE A 158
TRP A 150
 None
 1.33A 2qmzA-4xkbA:
undetectable
2qmzB-4xkbA:
undetectable		 2qmzA-4xkbA:
19.84
2qmzB-4xkbA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLN A 103
PHE A 105
TRP A 150
GLY A 156
 None
 1.05A 2qmzA-4xkbA:
undetectable
2qmzB-4xkbA:
undetectable		 2qmzA-4xkbA:
19.84
2qmzB-4xkbA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 ASN A 147
PHE A 160
TYR A  93
PHE A 138
 None
 0.97A 2wekA-4xkbA:
undetectable		 2wekA-4xkbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 ASN A 147
PHE A 160
TYR A  93
PHE A 138
 None
 0.96A 2wekB-4xkbA:
undetectable		 2wekB-4xkbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A  88
LYS A 137
PHE A 138
LEU A 130
TYR A  93
 None
 1.14A 3hj3B-4xkbA:
undetectable		 3hj3B-4xkbA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 219
VAL A 135
LEU A 119
LEU A 143
PHE A 160
 None
 1.35A 4zmeB-4xkbA:
undetectable		 4zmeB-4xkbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 LEU A 210
LEU A 116
PRO A 208
ILE A 146
LEU A 119
 None
 1.30A 5g48B-4xkbA:
undetectable		 5g48B-4xkbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4xkb YCF53-LIKE PROTEIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 LEU A 152
ILE A  82
TYR A  41
 None
 0.69A 5uunB-4xkbA:
undetectable		 5uunB-4xkbA:
22.33