SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		4 / 5 THR A 211
THR A 259
HIS A 295
HIS A 204
 NAD  A 401 (-4.5A)
None
NAD  A 401 (-3.7A)
None
 1.46A 1d4fD-4xkjA:
4.4		 1d4fD-4xkjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 11 THR A 202
GLY A 157
LEU A 109
ALA A 107
ALA A 110
 None
 0.97A 1x7pA-4xkjA:
2.7
1x7pB-4xkjA:
undetectable		 1x7pA-4xkjA:
24.44
1x7pB-4xkjA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 10 ALA A 232
ILE A 230
VAL A 160
ALA A 161
LEU A 167
 NAD  A 401 (-4.7A)
None
None
None
None
 1.17A 1xp0A-4xkjA:
undetectable		 1xp0A-4xkjA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 12 LEU A 203
LEU A 229
LEU A 243
ALA A 242
ALA A 219
 None
 1.16A 2bxpA-4xkjA:
undetectable		 2bxpA-4xkjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 11 LEU A 203
ILE A 151
GLY A 152
GLY A 157
LEU A 229
 None
None
NAD  A 401 (-3.4A)
None
None
 1.01A 2qmmA-4xkjA:
2.5
2qmmB-4xkjA:
2.3		 2qmmA-4xkjA:
21.80
2qmmB-4xkjA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 11 THR A  38
ILE A   4
ASN A  58
ILE A  50
VAL A 315
 None
 1.04A 3a51A-4xkjA:
undetectable		 3a51A-4xkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 12 THR A  38
ILE A   4
ASN A  58
ILE A  50
VAL A 315
 None
 1.02A 3a51C-4xkjA:
undetectable		 3a51C-4xkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 12 THR A  38
ILE A   4
ASN A  58
ILE A  50
VAL A 315
 None
 0.96A 3a51D-4xkjA:
undetectable		 3a51D-4xkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 12 THR A  38
ILE A   4
ASN A  58
ILE A  50
VAL A 315
 None
 0.89A 3a51E-4xkjA:
undetectable		 3a51E-4xkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 12 ASN A 289
VAL A 238
ILE A 252
LEU A 220
THR A 259
 None
 1.11A 3fl9B-4xkjA:
undetectable		 3fl9B-4xkjA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 11 ASN A 289
VAL A 238
ILE A 252
LEU A 220
THR A 259
 None
 1.11A 3fl9C-4xkjA:
undetectable		 3fl9C-4xkjA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		4 / 7 ASP A  84
LEU A  73
GLN A 327
LEU A 328
 None
 0.92A 4ib4A-4xkjA:
undetectable		 4ib4A-4xkjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 11 ALA A 242
LEU A 243
LEU A 284
LEU A 260
LEU A 257
 None
 1.20A 4wg0I-4xkjA:
undetectable
4wg0J-4xkjA:
undetectable
4wg0K-4xkjA:
undetectable		 4wg0I-4xkjA:
3.49
4wg0J-4xkjA:
3.49
4wg0K-4xkjA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		4 / 4 LEU A  34
ARG A  76
ILE A  48
PHE A   6
 None
 1.27A 5kirB-4xkjA:
0.0		 5kirB-4xkjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 12 ILE A  50
PHE A   6
ILE A  48
LEU A  73
VAL A  61
 None
 1.01A 5km9B-4xkjA:
undetectable		 5km9B-4xkjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 9 LEU A 203
ILE A 151
GLY A 152
GLY A 157
LEU A 229
 None
None
NAD  A 401 (-3.4A)
None
None
 0.88A 5o96A-4xkjA:
2.7
5o96B-4xkjA:
2.7		 5o96A-4xkjA:
22.51
5o96B-4xkjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 12 LEU A 203
ILE A 151
GLY A 152
GLY A 157
LEU A 229
 None
None
NAD  A 401 (-3.4A)
None
None
 0.93A 5twjA-4xkjA:
2.2		 5twjA-4xkjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4xkj D-LACTATE
DEHYDROGENASE
(Sporolactobacill
us
inulinus) 		5 / 10 LEU A 203
ILE A 151
GLY A 152
GLY A 157
LEU A 229
 None
None
NAD  A 401 (-3.4A)
None
None
 0.99A 5twjB-4xkjA:
2.2		 5twjB-4xkjA:
21.35