SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4xko HEAT SHOCK COGNATE
90 KDA PROTEIN
(Dictyostelium
discoideum) 		5 / 12 LEU A 133
THR A  25
ASP A 117
LEU A  18
LEU A  21
 None
 1.45A 1d4fD-4xkoA:
undetectable		 1d4fD-4xkoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4xko HEAT SHOCK COGNATE
90 KDA PROTEIN
(Dictyostelium
discoideum) 		5 / 12 ASP A  43
ASP A  82
MET A  87
ASP A 146
THR A 174
 None
None
PEG  A 301 ( 4.5A)
None
PEG  A 301 ( 4.9A)
 1.33A 1s14A-4xkoA:
10.4		 1s14A-4xkoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4xko HEAT SHOCK COGNATE
90 KDA PROTEIN
(Dictyostelium
discoideum) 		4 / 7 LEU A 178
ILE A 176
ASN A  40
PHE A 128
 None
None
PEG  A 301 (-4.1A)
PEG  A 301 ( 4.5A)
 0.93A 2opxA-4xkoA:
undetectable		 2opxA-4xkoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4xko HEAT SHOCK COGNATE
90 KDA PROTEIN
(Dictyostelium
discoideum) 		3 / 3 LYS A 143
LYS A  62
SER A  61
 None
 1.25A 5odiA-4xkoA:
undetectable		 5odiA-4xkoA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4xko HEAT SHOCK COGNATE
90 KDA PROTEIN
(Dictyostelium
discoideum) 		5 / 10 GLY A 127
GLY A 122
GLU A  36
VAL A  32
ILE A  22
 None
 1.10A 6exiA-4xkoA:
undetectable		 6exiA-4xkoA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4xko HEAT SHOCK COGNATE
90 KDA PROTEIN
(Dictyostelium
discoideum) 		5 / 10 GLY A 127
GLY A 122
GLU A  36
VAL A  32
ILE A  22
 None
 1.10A 6exiB-4xkoA:
undetectable		 6exiB-4xkoA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4xko HEAT SHOCK COGNATE
90 KDA PROTEIN
(Dictyostelium
discoideum) 		5 / 12 GLY A 127
GLY A 122
GLU A  36
VAL A  32
ILE A  22
 None
 1.09A 6exiC-4xkoA:
undetectable
6exiD-4xkoA:
undetectable		 6exiC-4xkoA:
16.09
6exiD-4xkoA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4xko HEAT SHOCK COGNATE
90 KDA PROTEIN
(Dictyostelium
discoideum) 		5 / 12 GLY A 127
GLY A 122
GLU A  36
VAL A  32
ILE A  22
 None
 1.12A 6exiC-4xkoA:
undetectable
6exiD-4xkoA:
undetectable		 6exiC-4xkoA:
16.09
6exiD-4xkoA:
16.09