SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 671
TYR A 709
TYR A 713
THR A 734
 None
 1.39A 1ceaA-4xkzA:
undetectable
1ceaB-4xkzA:
undetectable		 1ceaA-4xkzA:
16.10
1ceaB-4xkzA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 825
VAL A 806
GLY A 805
ALA A 847
LEU A 849
 None
 1.03A 1e7bA-4xkzA:
undetectable		 1e7bA-4xkzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 636
HIS A 637
HIS A 634
 None
 0.67A 1rkyA-4xkzA:
undetectable		 1rkyA-4xkzA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 874
GLU A 873
MET A 872
ILE A 823
HIS A 833
 None
 1.36A 1vhwA-4xkzA:
undetectable
1vhwD-4xkzA:
undetectable		 1vhwA-4xkzA:
17.92
1vhwD-4xkzA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 833
VAL A 874
GLU A 873
MET A 872
ILE A 823
 None
 1.36A 1vhwC-4xkzA:
undetectable
1vhwE-4xkzA:
undetectable		 1vhwC-4xkzA:
17.92
1vhwE-4xkzA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 636
HIS A 637
HIS A 634
 None
 0.68A 2w0qA-4xkzA:
undetectable		 2w0qA-4xkzA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 PRO A 664
VAL A 665
GLY A 733
ILE A 739
GLY A 659
 None
 1.47A 3csjB-4xkzA:
3.4		 3csjB-4xkzA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 665
GLN A 767
ILE A 675
GLY A 733
 None
None
IOD  A 902 ( 4.3A)
None
 0.82A 3hjoA-4xkzA:
3.6		 3hjoA-4xkzA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 810
ARG A 807
ILE A 821
 None
PGE  A 906 (-3.1A)
None
 0.87A 4b7qA-4xkzA:
undetectable		 4b7qA-4xkzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 810
ARG A 807
ILE A 821
 None
PGE  A 906 (-3.1A)
None
 0.81A 4b7qC-4xkzA:
undetectable		 4b7qC-4xkzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 851
ARG A 810
ILE A 852
GLU A 850
 None
 1.19A 4cx7A-4xkzA:
undetectable
4cx7B-4xkzA:
undetectable		 4cx7A-4xkzA:
20.92
4cx7B-4xkzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 867
ILE A 809
ILE A 821
LEU A 849
ILE A 823
 None
 1.21A 4dtaA-4xkzA:
undetectable		 4dtaA-4xkzA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 748
GLU A 682
LEU A 678
ILE A 764
ILE A 739
 None
 1.28A 4j26B-4xkzA:
undetectable		 4j26B-4xkzA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 TYR A 713
TYR A 709
ALA A 646
THR A 658
LEU A 721
 None
 1.39A 6ay6A-4xkzA:
undetectable		 6ay6A-4xkzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4xkz VALINE-TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 699
GLU A 703
TRP A 706
ALA A 631
 None
 1.35A 6f6jC-4xkzA:
undetectable
6f6jD-4xkzA:
undetectable		 6f6jC-4xkzA:
19.20
6f6jD-4xkzA:
19.20