SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		4 / 6 LEU B  62
PHE B  30
TYR B 169
VAL B 173
 MLY  B  63 ( 3.6A)
None
None
None
 1.32A 1ibgH-4xl1B:
undetectable		 1ibgH-4xl1B:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		5 / 12 ALA B  45
LEU B 139
THR B  56
GLN B 160
ILE B 119
 None
 1.23A 2jjpA-4xl1B:
undetectable		 2jjpA-4xl1B:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		5 / 12 SER B 170
PHE B  89
ARG B  33
ILE B  91
ASN B 101
 None
 1.29A 2vdyB-4xl1B:
undetectable		 2vdyB-4xl1B:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		4 / 5 VAL B 173
VAL B 174
THR B 110
ARG B 172
 None
None
None
MLY  B 153 ( 3.5A)
 1.12A 3bjwA-4xl1B:
undetectable		 3bjwA-4xl1B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		3 / 3 SER B 148
ALA B 150
VAL B 151
 None
 0.52A 4o2bA-4xl1B:
undetectable		 4o2bA-4xl1B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		3 / 3 SER B 148
ALA B 150
VAL B 151
 None
 0.32A 4x1iA-4xl1B:
undetectable		 4x1iA-4xl1B:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		3 / 3 SER B 148
ALA B 150
VAL B 151
 None
 0.37A 5eypA-4xl1B:
undetectable		 5eypA-4xl1B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		3 / 3 SER B 148
ALA B 150
VAL B 151
 None
 0.52A 5xiwC-4xl1B:
undetectable		 5xiwC-4xl1B:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		4 / 5 ILE B 140
PHE B  37
ARG B  41
THR B 163
 None
 1.29A 5z84N-4xl1B:
undetectable
5z84W-4xl1B:
undetectable		 5z84N-4xl1B:
17.12
5z84W-4xl1B:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		4 / 7 PHE B  37
ARG B 168
LEU B 167
ALA B 121
 None
 1.07A 6b89A-4xl1B:
undetectable		 6b89A-4xl1B:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xl1 DELTA-LIKE PROTEIN
(Rattus
norvegicus) 		4 / 5 LEU B 103
GLN B  31
PHE B  30
PHE B  58
 None
 1.37A 6nmpP-4xl1B:
undetectable
6nmpW-4xl1B:
undetectable		 6nmpP-4xl1B:
19.10
6nmpW-4xl1B:
16.08