SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4xl5 BGFP-A
(synthetic
construct) 		3 / 3 ASP C  74
ARG C  76
ASP C  43
 None
 0.95A 1vptA-4xl5C:
undetectable		 1vptA-4xl5C:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 11 ALA C  99
ILE C 103
GLY C  73
LEU C  81
ALA C  77
 None
 1.16A 3kw2A-4xl5C:
undetectable		 3kw2A-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 11 ALA C 192
ILE C 196
GLY C 166
LEU C 174
ALA C 170
 None
 1.23A 3kw2A-4xl5C:
undetectable		 3kw2A-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 11 ALA C  99
ILE C 103
GLY C  73
LEU C  81
ALA C  77
 None
 1.17A 3kw2B-4xl5C:
undetectable		 3kw2B-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 11 ALA C 192
ILE C 196
GLY C 166
LEU C 174
ALA C 170
 None
 1.24A 3kw2B-4xl5C:
undetectable		 3kw2B-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 11 ALA C 223
ILE C 227
GLY C 197
LEU C 205
ALA C 201
 None
 1.26A 3kw2B-4xl5C:
undetectable		 3kw2B-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLY C  39
GLY C  42
VAL C  47
ALA C  65
ALA C  64
 None
 1.03A 3mteA-4xl5C:
undetectable		 3mteA-4xl5C:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLY C  70
GLY C  73
VAL C  78
ALA C  96
ALA C  95
 None
 1.01A 3mteA-4xl5C:
undetectable		 3mteA-4xl5C:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLY C 163
GLY C 166
VAL C 171
ALA C 189
ALA C 188
 None
 0.98A 3mteA-4xl5C:
undetectable		 3mteA-4xl5C:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		6 / 12 GLY C  39
GLY C  42
VAL C  16
ALA C  34
ALA C  35
LEU C  50
 None
 1.26A 3p2kC-4xl5C:
undetectable		 3p2kC-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLY C 163
GLY C 166
VAL C 171
ALA C 189
ALA C 188
 None
 1.08A 3p2kC-4xl5C:
undetectable		 3p2kC-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLY C 225
GLY C 228
VAL C 202
ALA C 220
ALA C 221
 None
 1.09A 3p2kC-4xl5C:
undetectable		 3p2kC-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLY C  39
GLY C  42
VAL C  47
ALA C  65
ALA C  64
 None
 1.02A 3p2kD-4xl5C:
undetectable		 3p2kD-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLY C  70
GLY C  73
VAL C  78
ALA C  96
ALA C  95
 None
 1.00A 3p2kD-4xl5C:
undetectable		 3p2kD-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLY C 163
GLY C 166
VAL C 171
ALA C 189
ALA C 188
 None
 0.97A 3p2kD-4xl5C:
undetectable		 3p2kD-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4xl5 BGFP-A
(synthetic
construct) 		3 / 3 ASP C  74
ARG C  76
ASP C  43
 None
 0.87A 4fzvA-4xl5C:
undetectable		 4fzvA-4xl5C:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLU C 106
LEU C 112
GLY C 104
LEU C  81
ALA C  96
 None
 1.21A 5kbwA-4xl5C:
undetectable		 5kbwA-4xl5C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLU C 137
LEU C 143
GLY C 135
LEU C 112
ALA C 127
 None
 1.25A 5kbwA-4xl5C:
undetectable		 5kbwA-4xl5C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLU C 106
LEU C 112
GLY C 104
LEU C  81
ALA C  96
 None
 1.22A 5kc4E-4xl5C:
undetectable		 5kc4E-4xl5C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4xl5 BGFP-A
(synthetic
construct) 		5 / 12 GLU C 137
LEU C 143
GLY C 135
LEU C 112
ALA C 127
 None
 1.26A 5kc4E-4xl5C:
undetectable		 5kc4E-4xl5C:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4xl5 BGFP-A
(synthetic
construct) 		3 / 3 ASP C  74
ARG C  76
ASP C  43
 None
 0.82A 5zvgA-4xl5C:
undetectable		 5zvgA-4xl5C:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4xl5 BGFP-A
(synthetic
construct) 		3 / 3 ASP C  74
ARG C  76
ASP C  43
 None
 0.85A 5zvgB-4xl5C:
undetectable		 5zvgB-4xl5C:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4xl5 BGFP-A
(synthetic
construct) 		4 / 8 GLY C 163
LEU C 162
ALA C 170
GLU C 168
 None
 0.82A 6mdqA-4xl5C:
undetectable		 6mdqA-4xl5C:
16.40