SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xlg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
([Candida]
glabrata) 		4 / 7 PHE A 260
PRO A 280
ALA A 256
SER A 251
 None
 1.27A 1lquA-4xlgA:
undetectable		 1lquA-4xlgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
([Candida]
glabrata) 		5 / 12 LEU A 118
CYH A  13
THR A  30
ILE A  27
HIS A  40
 None
 1.12A 3sp9A-4xlgA:
undetectable		 3sp9A-4xlgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4
([Candida]
glabrata) 		4 / 6 MET A 126
PRO B 683
GLN A   5
PRO A   8
 None
 1.29A 3vkxA-4xlgA:
undetectable		 3vkxA-4xlgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
([Candida]
glabrata) 		4 / 5 TYR A  26
GLN A  83
GLY A  28
SER A  29
 None
 1.26A 4fu8A-4xlgA:
undetectable		 4fu8A-4xlgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
([Candida]
glabrata) 		3 / 3 LEU A 206
LYS A 203
THR A 202
 None
 0.54A 4lj0A-4xlgA:
undetectable		 4lj0A-4xlgA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4
([Candida]
glabrata;
[Candida]
glabrata) 		4 / 8 ASP B 673
ILE A 234
ARG B 677
TYR A 257
 None
 1.18A 6hisA-4xlgB:
undetectable
6hisB-4xlgB:
undetectable		 6hisA-4xlgB:
25.27
6hisB-4xlgB:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4
([Candida]
glabrata;
[Candida]
glabrata) 		4 / 8 ASP B 673
ILE A 234
ARG B 677
TYR A 257
 None
 1.19A 6hisB-4xlgB:
undetectable
6hisC-4xlgB:
undetectable		 6hisB-4xlgB:
25.27
6hisC-4xlgB:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4
([Candida]
glabrata;
[Candida]
glabrata) 		4 / 8 ASP B 673
ILE A 234
ARG B 677
TYR A 257
 None
 1.18A 6hisC-4xlgB:
undetectable
6hisD-4xlgB:
undetectable		 6hisC-4xlgB:
25.27
6hisD-4xlgB:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4
([Candida]
glabrata;
[Candida]
glabrata) 		4 / 8 ASP B 673
ILE A 234
ARG B 677
TYR A 257
 None
 1.20A 6hisD-4xlgB:
undetectable
6hisE-4xlgB:
undetectable		 6hisD-4xlgB:
25.27
6hisE-4xlgB:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4
([Candida]
glabrata;
[Candida]
glabrata) 		4 / 8 TYR A 257
ASP B 673
ILE A 234
ARG B 677
 None
 1.19A 6hisA-4xlgA:
undetectable
6hisE-4xlgA:
undetectable		 6hisA-4xlgA:
14.24
6hisE-4xlgA:
14.24