SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424
(Homo
sapiens) 		5 / 11 ALA H 137
THR H 183
GLY H 134
GLY H 133
SER H 132
 None
 1.07A 4qvwK-4xmlH:
undetectable
4qvwL-4xmlH:
undetectable		 4qvwK-4xmlH:
22.98
4qvwL-4xmlH:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424
(Homo
sapiens) 		5 / 11 ALA H 137
THR H 183
GLY H 134
GLY H 133
SER H 132
 None
 1.07A 4qvwY-4xmlH:
undetectable
4qvwZ-4xmlH:
undetectable		 4qvwY-4xmlH:
22.98
4qvwZ-4xmlH:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424
(Homo
sapiens) 		4 / 7 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.72A 5ecmD-4xmlH:
undetectable		 5ecmD-4xmlH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424
(Homo
sapiens) 		4 / 7 ALA H  88
THR H  87
VAL H 109
GLU H  85
 None
 0.84A 5ecoD-4xmlH:
undetectable		 5ecoD-4xmlH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424
(Homo
sapiens) 		5 / 12 GLY H  84
LEU H  20
GLY H 104
PHE H  67
THR H  87
 None
 1.00A 5eskA-4xmlH:
undetectable		 5eskA-4xmlH:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424
(Homo
sapiens) 		3 / 3 PRO H 185
SER H 187
SER H 188
 None
 0.69A 6bpyA-4xmlH:
undetectable		 6bpyA-4xmlH:
20.87