SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
ILE E 397
LEU E 631
 None
 1.04A 1ddrA-4xmmE:
undetectable		 1ddrA-4xmmE:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
ILE E 397
LEU E 631
 None
 1.03A 1ddsB-4xmmE:
undetectable		 1ddsB-4xmmE:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
ILE E 397
LEU E 631
 None
 1.06A 1dyiB-4xmmE:
undetectable		 1dyiB-4xmmE:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 11 SER E 683
LEU E 680
LEU E 698
SER E 615
LEU E 705
 None
 1.39A 1ee2A-4xmmE:
undetectable		 1ee2A-4xmmE:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 11 SER E 683
LEU E 680
LEU E 698
SER E 615
LEU E 705
 None
 1.39A 1ee2B-4xmmE:
undetectable		 1ee2B-4xmmE:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 7 ASP E 258
LEU E 293
SER E 263
ASN E 318
 None
 1.24A 1ig3A-4xmmE:
undetectable
1ig3B-4xmmE:
undetectable		 1ig3A-4xmmE:
15.04
1ig3B-4xmmE:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 6 SER B 522
THR B 523
LEU B 191
ASP B 192
 None
 1.35A 1mxdA-4xmmB:
undetectable		 1mxdA-4xmmB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 6 LEU E 293
VAL E 335
ILE E 331
MET E 259
 None
 1.13A 1opjB-4xmmE:
undetectable		 1opjB-4xmmE:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 11 THR E 249
PHE E 173
PHE E 199
SER E 250
VAL E 236
 None
 1.50A 1q23G-4xmmE:
undetectable		 1q23G-4xmmE:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
LEU E 631
ILE E 528
 None
 0.98A 1ra3A-4xmmE:
undetectable		 1ra3A-4xmmE:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
ILE E 397
LEU E 631
 None
 1.12A 1rx3A-4xmmE:
undetectable		 1rx3A-4xmmE:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 10 HIS E 151
THR E 130
GLN E 132
TYR E 194
ASP E 190
 None
 1.11A 1td2A-4xmmE:
undetectable		 1td2A-4xmmE:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 400
ALA B 427
LEU B 403
SER B 406
 None
 1.10A 1tt6B-4xmmB:
undetectable		 1tt6B-4xmmB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 435
ALA B 427
LEU B 425
SER B 238
 None
 0.89A 1tz8C-4xmmB:
undetectable
1tz8D-4xmmB:
undetectable		 1tz8C-4xmmB:
12.37
1tz8D-4xmmB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 425
PRO B 418
VAL B 421
ILE B 422
 None
 0.96A 2aoiB-4xmmB:
undetectable		 2aoiB-4xmmB:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
LEU E 533
ILE E 397
LEU E 631
ILE E 528
 None
 0.93A 2d0kB-4xmmE:
undetectable		 2d0kB-4xmmE:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
LEU E 631
ILE E 528
 None
 1.02A 2drcA-4xmmE:
undetectable		 2drcA-4xmmE:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
LEU E 631
ILE E 528
 None
 1.04A 2drcB-4xmmE:
undetectable		 2drcB-4xmmE:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 537
ILE B 533
LEU B 519
ARG B 520
ILE B 516
 None
 0.85A 2f78A-4xmmB:
undetectable		 2f78A-4xmmB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 537
ILE B 533
LEU B 519
ARG B 520
ILE B 516
 None
 0.87A 2f7aA-4xmmB:
undetectable		 2f7aA-4xmmB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 10 LEU B 537
ILE B 533
LEU B 519
ARG B 520
ILE B 516
 None
 0.85A 2f8dA-4xmmB:
undetectable		 2f8dA-4xmmB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 6 LEU E 293
VAL E 335
ILE E 331
MET E 259
 None
 1.16A 2hyyC-4xmmE:
undetectable		 2hyyC-4xmmE:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 478
LEU B 531
HIS B 490
LEU B 185
TYR B 190
 None
 1.50A 2prgB-4xmmB:
undetectable		 2prgB-4xmmB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 6 LEU E 386
LEU E 389
ILE E 625
ARG E 628
 None
 0.97A 2rlfB-4xmmE:
undetectable
2rlfC-4xmmE:
undetectable		 2rlfB-4xmmE:
4.53
2rlfC-4xmmE:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 10 LEU E 639
LEU E 635
SER E 521
LEU E 520
LEU E 558
 None
 1.13A 2xn7A-4xmmE:
undetectable
2xn7B-4xmmE:
undetectable		 2xn7A-4xmmE:
15.76
2xn7B-4xmmE:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 232
GLN B 276
ILE B 240
SER B 275
 None
 1.17A 2xz5B-4xmmB:
undetectable
2xz5E-4xmmB:
undetectable		 2xz5B-4xmmB:
16.64
2xz5E-4xmmB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 5 PHE E 571
PHE E 640
LEU E 639
PHE E 562
 None
 1.33A 2y69P-4xmmE:
undetectable
2y69W-4xmmE:
undetectable		 2y69P-4xmmE:
13.88
2y69W-4xmmE:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 6 ARG E 526
ASP E 396
GLU E 447
TYR E 415
 None
 1.20A 2ya7C-4xmmE:
3.2		 2ya7C-4xmmE:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		4 / 7 VAL C  59
SER C  57
LEU C  11
TRP C 308
 None
 1.17A 3arrA-4xmmC:
undetectable		 3arrA-4xmmC:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 292
LEU B 361
ILE B 323
SER B 308
ILE B 355
 None
 1.09A 3cd2A-4xmmB:
undetectable		 3cd2A-4xmmB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 5 PRO E  18
PRO E  20
TYR E  88
TYR E  15
 None
 1.25A 3d9lA-4xmmE:
undetectable
3d9lY-4xmmE:
undetectable		 3d9lA-4xmmE:
8.23
3d9lY-4xmmE:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
LEU E 631
ILE E 528
 None
 1.02A 3drcA-4xmmE:
undetectable		 3drcA-4xmmE:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
LEU E 631
ILE E 528
 None
 1.03A 3drcB-4xmmE:
undetectable		 3drcB-4xmmE:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 188
LEU B 191
GLN B 449
 None
 0.71A 3g4lA-4xmmB:
undetectable		 3g4lA-4xmmB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 7 CYH B 384
PHE B 411
PHE B 367
PHE B 380
 None
 1.21A 3hggA-4xmmB:
undetectable		 3hggA-4xmmB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 7 LEU E 664
LEU E 679
SER E 704
ASN E 706
 None
 1.03A 3lm8A-4xmmE:
undetectable
3lm8C-4xmmE:
undetectable		 3lm8A-4xmmE:
11.96
3lm8C-4xmmE:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 7 LEU E 664
LEU E 679
SER E 704
ASN E 706
 None
 1.00A 3lm8B-4xmmE:
undetectable
3lm8D-4xmmE:
undetectable		 3lm8B-4xmmE:
11.96
3lm8D-4xmmE:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 11 HIS E 151
THR E 130
GLN E 132
TYR E 194
ASP E 190
 None
 1.13A 3mbhA-4xmmE:
undetectable		 3mbhA-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 11 VAL E 192
HIS E 151
THR E 130
GLN E 132
ASP E 190
 None
 1.41A 3mbhA-4xmmE:
undetectable		 3mbhA-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 HIS E 151
THR E 130
GLN E 132
TYR E 194
ASP E 190
 None
 1.14A 3mbhB-4xmmE:
undetectable		 3mbhB-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 VAL E 192
HIS E 151
THR E 130
GLN E 132
ASP E 190
 None
 1.40A 3mbhB-4xmmE:
undetectable		 3mbhB-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 HIS E 151
THR E 130
GLN E 132
TYR E 194
ASP E 190
 None
 1.12A 3mbhC-4xmmE:
undetectable		 3mbhC-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 VAL E 192
HIS E 151
THR E 130
GLN E 132
ASP E 190
 None
 1.41A 3mbhC-4xmmE:
undetectable		 3mbhC-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 HIS E 151
THR E 130
GLN E 132
TYR E 194
ASP E 190
 None
 1.15A 3mbhD-4xmmE:
undetectable		 3mbhD-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 VAL E 192
HIS E 151
THR E 130
GLN E 132
ASP E 190
 None
 1.40A 3mbhD-4xmmE:
undetectable		 3mbhD-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 HIS E 151
THR E 130
GLN E 132
TYR E 194
ASP E 190
 None
 1.10A 3mbhE-4xmmE:
undetectable		 3mbhE-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 VAL E 192
HIS E 151
THR E 130
GLN E 132
ASP E 190
 None
 1.41A 3mbhE-4xmmE:
undetectable		 3mbhE-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 11 HIS E 151
THR E 130
GLN E 132
TYR E 194
ASP E 190
 None
 1.12A 3mbhF-4xmmE:
undetectable		 3mbhF-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 11 VAL E 192
HIS E 151
THR E 130
GLN E 132
ASP E 190
 None
 1.42A 3mbhF-4xmmE:
undetectable		 3mbhF-4xmmE:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		6 / 12 LEU B 498
GLU B 194
ILE B 508
LEU B 492
VAL B 494
SER B 495
 None
 1.47A 3nk7B-4xmmB:
undetectable		 3nk7B-4xmmB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 420
ILE B 422
LEU B 269
ARG B 265
VAL B 404
 None
 1.07A 3o7wA-4xmmB:
undetectable		 3o7wA-4xmmB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 ARG B 182
LEU B 185
THR B 178
 None
 0.69A 3oxcA-4xmmB:
undetectable		 3oxcA-4xmmB:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 9 HIS E 164
PRO E 163
LEU E 184
LEU E 186
SER E 174
 None
 1.34A 3q1eB-4xmmE:
undetectable
3q1eD-4xmmE:
undetectable		 3q1eB-4xmmE:
8.33
3q1eD-4xmmE:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		3 / 3 PHE E 476
LYS E 356
SER E 361
 None
 1.00A 3tyeB-4xmmE:
undetectable		 3tyeB-4xmmE:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		3 / 3 GLN E 424
PHE E 408
TYR E 442
 None
 1.01A 3ucjA-4xmmE:
undetectable		 3ucjA-4xmmE:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 4 LEU B 326
ILE B 292
TYR B 298
TYR B 359
 None
 1.40A 3vt7A-4xmmB:
undetectable		 3vt7A-4xmmB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		5 / 11 ALA C 126
GLY C 132
VAL C 185
LEU C 171
GLY C 129
 None
 1.01A 3zosA-4xmmC:
undetectable
3zosB-4xmmC:
undetectable		 3zosA-4xmmC:
20.44
3zosB-4xmmC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 5 SER E 504
GLY E 503
THR E 489
ASP E 502
 None
 1.13A 4eohA-4xmmE:
undetectable		 4eohA-4xmmE:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 553
ASP E 534
LEU E 533
ILE E 397
LEU E 631
 None
 1.06A 4gh8A-4xmmE:
undetectable		 4gh8A-4xmmE:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		4 / 6 GLU C  86
ARG C  70
GLU C  92
SER C  48
 None
 1.40A 4kr3A-4xmmC:
undetectable		 4kr3A-4xmmC:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ASN E  94
GLN E 477
ASN E 480
ASN E  10
LEU E  12
 None
 1.38A 4kukA-4xmmE:
undetectable		 4kukA-4xmmE:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 ASN E  94
GLN E 477
ASN E 480
ASN E  10
LEU E  12
 None
 1.46A 4kuoA-4xmmE:
undetectable		 4kuoA-4xmmE:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		3 / 3 HIS C  13
TRP C 308
SER C  57
 None
 1.14A 4lrhD-4xmmC:
undetectable		 4lrhD-4xmmC:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 10 LEU B 400
LEU B 390
ILE B 273
LEU B 386
PHE B 423
 None
 1.05A 4odoC-4xmmB:
undetectable		 4odoC-4xmmB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 400
LEU B 390
ILE B 273
LEU B 386
PHE B 423
 None
 1.03A 4odrA-4xmmB:
undetectable
4odrB-4xmmB:
undetectable		 4odrA-4xmmB:
9.97
4odrB-4xmmB:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 11 ILE E 553
ASP E 534
LEU E 533
LEU E 631
ILE E 528
 None
 0.99A 4p66A-4xmmE:
undetectable		 4p66A-4xmmE:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		3 / 3 ASP E 396
GLU E 447
SER E 529
 None
 0.71A 5bw4B-4xmmE:
undetectable		 5bw4B-4xmmE:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		5 / 11 ALA C 117
ARG C 196
LEU C 183
LEU C 136
HIS C 120
 None
 1.23A 5eb5A-4xmmC:
undetectable		 5eb5A-4xmmC:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		3 / 3 TRP C  51
ILE C  58
SER C  74
 None
 0.94A 5gqbA-4xmmC:
undetectable		 5gqbA-4xmmC:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		5 / 12 LEU E 570
LEU E 583
ILE E 579
LEU E 642
LEU E 510
 None
 1.15A 5ienA-4xmmE:
undetectable		 5ienA-4xmmE:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		4 / 7 ILE E  95
PHE E  81
THR E 109
LEU E 108
 None
 0.94A 5iy5N-4xmmE:
0.8
5iy5W-4xmmE:
undetectable		 5iy5N-4xmmE:
18.96
5iy5W-4xmmE:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 8 SER B 328
ARG B 332
PRO B 331
ILE B 333
 None
 1.09A 5jhdE-4xmmB:
undetectable
5jhdG-4xmmB:
undetectable		 5jhdE-4xmmB:
17.00
5jhdG-4xmmB:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4xmm NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 12 TRP B 235
ASP B 231
LEU B 234
ASP B 447
PHE B 184
 None
 1.20A 5nn6A-4xmmB:
undetectable		 5nn6A-4xmmB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 192
LEU C 128
PHE C 169
ARG C 216
 None
 1.03A 5vc0A-4xmmC:
undetectable		 5vc0A-4xmmC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		4 / 5 TRP C 173
LEU C 171
VAL C 185
LEU C 134
 None
 0.97A 5xooB-4xmmC:
undetectable		 5xooB-4xmmC:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4xmm NUCLEOPORIN SEH1
(Saccharomyces
cerevisiae) 		4 / 4 VAL C 307
GLY C 238
ASP C 237
ASP C 301
 None
 1.28A 6cjkC-4xmmC:
undetectable		 6cjkC-4xmmC:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4xmm NUCLEOPORIN NUP120
(Saccharomyces
cerevisiae) 		3 / 3 GLN E 104
TYR E 106
ASN E 103
 None
 0.91A 6dwdC-4xmmE:
undetectable		 6dwdC-4xmmE:
20.89