SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		4 / 5 GLY H  95
GLN H 101
VAL H   2
SER H  97
 None
None
PCA  H   1 ( 3.3A)
None
 1.27A 1p6kB-4xmpH:
undetectable		 1p6kB-4xmpH:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		4 / 5 GLY H  95
GLN H 101
VAL H   2
SER H  97
 None
None
PCA  H   1 ( 3.3A)
None
 1.26A 1rs6B-4xmpH:
undetectable		 1rs6B-4xmpH:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		4 / 5 GLY H  95
GLN H 101
VAL H   2
SER H  97
 None
None
PCA  H   1 ( 3.3A)
None
 1.49A 1zzqB-4xmpH:
undetectable		 1zzqB-4xmpH:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		4 / 5 GLY H  95
GLN H 101
VAL H   2
SER H  97
 None
None
PCA  H   1 ( 3.3A)
None
 1.27A 1zzuB-4xmpH:
undetectable		 1zzuB-4xmpH:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4xmp LIGHT CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.89A 2aojA-4xmpL:
undetectable		 2aojA-4xmpL:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4xmp LIGHT CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		4 / 7 GLU L  17
VAL L  19
LEU L  21
TYR L  86
 None
 0.99A 3qeoB-4xmpL:
undetectable		 3qeoB-4xmpL:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4xmp LIGHT CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		4 / 4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 0.93A 3tgvB-4xmpL:
undetectable		 3tgvB-4xmpL:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
LIGHT CHAIN OF
ANTIBODY VRC08
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ILE H  20
PRO L  44
VAL H  93
TRP H 103
 None
 1.12A 4f4dB-4xmpH:
undetectable		 4f4dB-4xmpH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		5 / 12 GLY H  85
ILE H  34
GLY H 104
PHE H  63
THR H  87
 None
 1.10A 4zdyA-4xmpH:
undetectable		 4zdyA-4xmpH:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		5 / 12 GLY H  85
LEU H  80
ILE H  34
GLY H 104
THR H  87
 None
 1.09A 5eskA-4xmpH:
undetectable		 5eskA-4xmpH:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		5 / 12 GLY H  85
LEU H  80
ILE H  34
PHE H  63
THR H  87
 None
 1.12A 5eskA-4xmpH:
undetectable		 5eskA-4xmpH:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		5 / 12 GLY H  85
ILE H  34
GLY H 104
PHE H  63
THR H  87
 None
 1.08A 5eslA-4xmpH:
undetectable		 5eslA-4xmpH:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
LIGHT CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		5 / 12 PHE L 118
LEU L 135
SER H 132
VAL L 196
HIS L 198
 None
 1.48A 5h1eA-4xmpL:
undetectable		 5h1eA-4xmpL:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4xmp LIGHT CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		3 / 3 ARG L  77
GLY L  16
GLU L  17
 None
 0.61A 6fgdA-4xmpL:
undetectable		 6fgdA-4xmpL:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		5 / 12 THR H  83
VAL H 111
VAL H 109
VAL H  67
TYR H  90
 None
 1.29A 6iblA-4xmpH:
undetectable		 6iblA-4xmpH:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4xmp HEAVY CHAIN OF
ANTIBODY VRC08
(Homo
sapiens) 		5 / 12 THR H  83
VAL H 111
VAL H 109
VAL H  67
TYR H  90
 None
 1.30A 6iblB-4xmpH:
undetectable		 6iblB-4xmpH:
18.62