SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xmr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		4 / 7 VAL A 192
GLY A 194
THR A 164
THR A 178
 None
 0.82A 1gtnC-4xmrA:
undetectable
1gtnD-4xmrA:
undetectable		 1gtnC-4xmrA:
13.78
1gtnD-4xmrA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		5 / 11 LEU A 215
THR A 273
THR A  61
THR A 209
ILE A 276
 None
 1.14A 1pkvA-4xmrA:
undetectable
1pkvB-4xmrA:
undetectable		 1pkvA-4xmrA:
16.54
1pkvB-4xmrA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		5 / 11 ILE A 276
LEU A 215
THR A 273
THR A  61
THR A 209
 None
 1.13A 1pkvA-4xmrA:
undetectable
1pkvB-4xmrA:
undetectable		 1pkvA-4xmrA:
16.54
1pkvB-4xmrA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		3 / 3 THR A  42
PRO A  40
THR A  44
 None
 0.65A 209dC-4xmrA:
undetectable		 209dC-4xmrA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		5 / 12 ILE A 197
ALA A 114
THR A 178
LEU A 193
TYR A 118
 None
None
None
None
ILE  A 301 (-3.6A)
 1.28A 2japD-4xmrA:
undetectable		 2japD-4xmrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		6 / 10 LEU A 119
VAL A 101
GLY A 102
GLY A 120
LEU A 121
LEU A 140
 None
 1.25A 2v3kA-4xmrA:
undetectable		 2v3kA-4xmrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM0_B_KANB302_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		5 / 11 THR A 178
TYR A 118
LEU A 128
ARG A 141
VAL A 176
 None
ILE  A 301 (-3.6A)
ILE  A 301 ( 4.8A)
None
None
 1.31A 4em0B-4xmrA:
0.0		 4em0B-4xmrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		3 / 3 LEU A  46
LYS A  43
THR A  42
 None
 0.63A 4lj0A-4xmrA:
undetectable		 4lj0A-4xmrA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		5 / 9 LEU A  58
ALA A 274
VAL A 206
GLY A 211
THR A  64
 None
 1.46A 5w5vA-4xmrA:
undetectable		 5w5vA-4xmrA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN
(Campylobacter
jejuni) 		4 / 7 ALA A 265
GLY A 264
LEU A 263
GLY A 211
 None
 0.74A 6nm4A-4xmrA:
undetectable		 6nm4A-4xmrA:
21.62