SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xmv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 ASP A 427
ASP A 432
ASP A 420
 None
 0.61A 1eizA-4xmvA:
undetectable		 1eizA-4xmvA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 ASP A 427
ASP A 432
ASP A 420
 None
 0.62A 1ej0A-4xmvA:
undetectable		 1ej0A-4xmvA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 10 ALA A  38
LEU A  54
ALA A  42
PHE A 187
ILE A  23
 None
 1.13A 1g5yC-4xmvA:
undetectable		 1g5yC-4xmvA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 TRP A  71
VAL A  82
TRP A  74
 GOL  A 914 ( 3.8A)
None
None
 1.29A 1gmkC-4xmvA:
undetectable
1gmkD-4xmvA:
undetectable		 1gmkC-4xmvA:
1.84
1gmkD-4xmvA:
1.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 7 GLU A 734
VAL A 745
MET A 746
LEU A 714
 None
 1.00A 1hk3A-4xmvA:
undetectable		 1hk3A-4xmvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.73A 1j36A-4xmvA:
7.3		 1j36A-4xmvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.73A 1j36B-4xmvA:
7.7		 1j36B-4xmvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.72A 1j37A-4xmvA:
5.1		 1j37A-4xmvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.73A 1j37B-4xmvA:
3.9		 1j37B-4xmvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 5 GLU A 642
ARG A 728
ASP A 729
THR A 764
 None
 1.14A 1k4tA-4xmvA:
undetectable		 1k4tA-4xmvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.69A 1o86A-4xmvA:
7.7		 1o86A-4xmvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 5 GLU A 642
ARG A 728
ASP A 729
THR A 764
 None
 1.20A 1rr8C-4xmvA:
1.7		 1rr8C-4xmvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 5 GLU A 642
ARG A 728
ASP A 729
THR A 764
 None
 1.17A 1rrjA-4xmvA:
undetectable		 1rrjA-4xmvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 6 LEU A 334
TRP A 236
ASN A 232
PHE A 300
 None
 1.26A 1rukH-4xmvA:
2.3
1rukL-4xmvA:
2.4		 1rukH-4xmvA:
13.95
1rukL-4xmvA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 PHE A 436
VAL A 387
ILE A 388
HIS A 392
PHE A 421
 None
 1.16A 1tcoC-4xmvA:
undetectable		 1tcoC-4xmvA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 VAL A  64
VAL A  62
TRP A  74
 None
 0.96A 1w5uA-4xmvA:
undetectable
1w5uB-4xmvA:
undetectable		 1w5uA-4xmvA:
1.84
1w5uB-4xmvA:
1.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 10 LEU A 851
LEU A 848
ILE A 827
ILE A 632
LEU A 833
 None
 1.20A 1wopA-4xmvA:
undetectable		 1wopA-4xmvA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.17A 1ya3C-4xmvA:
undetectable		 1ya3C-4xmvA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		6 / 12 ALA A 262
HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 None
ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.67A 2c6nA-4xmvA:
3.1		 2c6nA-4xmvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.74A 2c6nB-4xmvA:
undetectable		 2c6nB-4xmvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 7 LEU A 247
PRO A 179
GLY A 413
ASP A 412
 None
 0.98A 2ddwB-4xmvA:
2.3		 2ddwB-4xmvA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 6 LEU A 268
MET A 227
MET A 234
LEU A 211
 None
 1.27A 2oz7A-4xmvA:
undetectable		 2oz7A-4xmvA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 LEU A 826
LEU A 808
ILE A 786
PHE A 807
LEU A 769
 None
 1.03A 2q6hA-4xmvA:
0.3		 2q6hA-4xmvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 6 ILE A 364
SER A 317
ILE A 391
PHE A 436
 None
 1.11A 2q72A-4xmvA:
undetectable		 2q72A-4xmvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 826
LEU A 808
ILE A 786
PHE A 807
LEU A 769
 None
 1.00A 2qb4A-4xmvA:
undetectable		 2qb4A-4xmvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 LEU A 826
LEU A 808
ILE A 786
PHE A 807
LEU A 769
 None
 1.00A 2qeiA-4xmvA:
undetectable		 2qeiA-4xmvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 LEU A 826
LEU A 808
ILE A 786
PHE A 807
LEU A 769
 None
 1.00A 2qjuA-4xmvA:
undetectable		 2qjuA-4xmvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.62A 2x8zA-4xmvA:
8.5		 2x8zA-4xmvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.65A 2x91A-4xmvA:
4.5		 2x91A-4xmvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 ASP A 427
ASP A 432
ASP A 420
 None
 0.53A 3douA-4xmvA:
undetectable		 3douA-4xmvA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 GLU A 398
SER A 429
VAL A 431
 None
 0.84A 3eeoA-4xmvA:
undetectable		 3eeoA-4xmvA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 GLU A 355
HIS A 362
THR A 377
 None
 0.87A 3hkuA-4xmvA:
undetectable		 3hkuA-4xmvA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 8 ALA A 415
ARG A 311
THR A 417
LEU A 318
 None
 0.88A 3hrdA-4xmvA:
undetectable
3hrdB-4xmvA:
undetectable		 3hrdA-4xmvA:
20.59
3hrdB-4xmvA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 LEU A 189
ILE A 145
ALA A 115
ALA A  31
ALA A 147
 None
 1.09A 3mdtB-4xmvA:
undetectable		 3mdtB-4xmvA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 TYR A 288
ALA A 223
SER A 229
ASP A 199
LEU A 197
 None
None
None
GOL  A 915 (-2.9A)
None
 1.40A 3ou6D-4xmvA:
undetectable		 3ou6D-4xmvA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 6 GLU A 624
PRO A 539
ARG A 349
GLY A 350
 None
 1.41A 3oxvA-4xmvA:
undetectable		 3oxvA-4xmvA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 HIS A 301
SER A 233
ASN A 269
 ZN  A 901 ( 3.2A)
None
None
 0.89A 3s8pB-4xmvA:
undetectable		 3s8pB-4xmvA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 ARG A 161
GLY A 267
GLY A 159
GLU A 212
ASN A 265
 None
 1.25A 3sxjA-4xmvA:
undetectable		 3sxjA-4xmvA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 ARG A 161
GLY A 267
GLY A 159
GLU A 212
ASN A 265
 None
 1.25A 3sxjB-4xmvA:
undetectable		 3sxjB-4xmvA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 ARG A 161
GLY A 267
GLY A 159
GLU A 212
ASN A 265
 None
 1.21A 3t7sA-4xmvA:
undetectable		 3t7sA-4xmvA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 ARG A 161
GLY A 267
GLY A 159
GLU A 212
ASN A 265
 None
 1.22A 3t7sB-4xmvA:
undetectable		 3t7sB-4xmvA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 ARG A 161
GLY A 267
GLY A 159
GLU A 212
ASN A 265
 None
 1.19A 3t7sC-4xmvA:
undetectable		 3t7sC-4xmvA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 ARG A 161
GLY A 267
GLY A 159
GLU A 212
ASN A 265
 None
 1.22A 3t7sD-4xmvA:
undetectable		 3t7sD-4xmvA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 8 HIS A 672
GLY A 335
ALA A 611
SER A 336
GLU A 615
 GOL  A 916 (-4.1A)
GOL  A 916 ( 3.5A)
GOL  A 916 ( 4.2A)
None
None
 1.29A 3u9hA-4xmvA:
undetectable		 3u9hA-4xmvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 8 HIS A 672
GLY A 335
ALA A 611
SER A 336
GLU A 615
 GOL  A 916 (-4.1A)
GOL  A 916 ( 3.5A)
GOL  A 916 ( 4.2A)
None
None
 1.24A 3u9hB-4xmvA:
undetectable		 3u9hB-4xmvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 8 HIS A 672
GLY A 335
ALA A 611
SER A 336
GLU A 615
 GOL  A 916 (-4.1A)
GOL  A 916 ( 3.5A)
GOL  A 916 ( 4.2A)
None
None
 1.29A 4bjcA-4xmvA:
undetectable		 4bjcA-4xmvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 381
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.72A 4c2pA-4xmvA:
7.8		 4c2pA-4xmvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 9 GLY A 261
HIS A 297
GLU A 298
GLU A 320
TYR A 381
 GOL  A 909 (-3.7A)
ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.35A 4dprA-4xmvA:
30.7		 4dprA-4xmvA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.04A 4fn9A-4xmvA:
undetectable		 4fn9A-4xmvA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.10A 4fn9B-4xmvA:
undetectable		 4fn9B-4xmvA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 PHE A 154
VAL A 196
GLU A 212
 None
 0.81A 4fvqA-4xmvA:
undetectable		 4fvqA-4xmvA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 7 HIS A 672
GLY A 335
ALA A 611
SER A 336
GLU A 615
 GOL  A 916 (-4.1A)
GOL  A 916 ( 3.5A)
GOL  A 916 ( 4.2A)
None
None
 1.37A 4hyfA-4xmvA:
undetectable		 4hyfA-4xmvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 8 HIS A 672
GLY A 335
ALA A 611
SER A 336
GLU A 615
 GOL  A 916 (-4.1A)
GOL  A 916 ( 3.5A)
GOL  A 916 ( 4.2A)
None
None
 1.42A 4hyfB-4xmvA:
undetectable		 4hyfB-4xmvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 8 HIS A 672
GLY A 335
ALA A 611
SER A 336
GLU A 615
 GOL  A 916 (-4.1A)
GOL  A 916 ( 3.5A)
GOL  A 916 ( 4.2A)
None
None
 1.37A 4hyfC-4xmvA:
undetectable		 4hyfC-4xmvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.06A 4ltwA-4xmvA:
undetectable		 4ltwA-4xmvA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		7 / 12 ALA A 122
HIS A 297
GLU A 298
HIS A 301
TRP A 313
GLU A 320
TYR A 381
 None
ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
None
ZN  A 901 ( 2.1A)
GOL  A 910 ( 3.5A)
 0.34A 4r7lA-4xmvA:
40.0		 4r7lA-4xmvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 HIS A 297
GLU A 298
HIS A 301
GLU A 320
TYR A 376
 ZN  A 901 ( 3.2A)
ARG  A 902 (-2.8A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 2.1A)
ARG  A 902 ( 3.8A)
 1.28A 4r7lA-4xmvA:
40.0		 4r7lA-4xmvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 HIS A 672
GLY A 335
ALA A 611
SER A 336
GLU A 615
 GOL  A 916 (-4.1A)
GOL  A 916 ( 3.5A)
GOL  A 916 ( 4.2A)
None
None
 1.49A 4rv6A-4xmvA:
undetectable		 4rv6A-4xmvA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 HIS A 672
GLY A 335
ALA A 611
SER A 336
GLU A 615
 GOL  A 916 (-4.1A)
GOL  A 916 ( 3.5A)
GOL  A 916 ( 4.2A)
None
None
 1.49A 4rv6B-4xmvA:
undetectable		 4rv6B-4xmvA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 LEU A 699
GLU A 655
ALA A 658
LEU A 657
TYR A 660
 None
 1.03A 4wg0B-4xmvA:
undetectable
4wg0C-4xmvA:
undetectable
4wg0D-4xmvA:
undetectable		 4wg0B-4xmvA:
1.38
4wg0C-4xmvA:
1.38
4wg0D-4xmvA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 LEU A 699
GLU A 655
ALA A 658
LEU A 657
TYR A 660
 None
 1.02A 4wg0D-4xmvA:
undetectable
4wg0E-4xmvA:
undetectable
4wg0F-4xmvA:
undetectable		 4wg0D-4xmvA:
1.38
4wg0E-4xmvA:
1.38
4wg0F-4xmvA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 LEU A 699
GLU A 655
ALA A 658
LEU A 657
TYR A 660
 None
 1.03A 4wg0F-4xmvA:
undetectable
4wg0G-4xmvA:
undetectable
4wg0H-4xmvA:
undetectable		 4wg0F-4xmvA:
1.38
4wg0G-4xmvA:
1.38
4wg0H-4xmvA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 LEU A 699
GLU A 655
ALA A 658
LEU A 657
TYR A 660
 None
 1.14A 4wg0H-4xmvA:
undetectable
4wg0I-4xmvA:
undetectable
4wg0J-4xmvA:
undetectable		 4wg0H-4xmvA:
1.38
4wg0I-4xmvA:
1.38
4wg0J-4xmvA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 GLU A 655
ALA A 658
LEU A 657
TYR A 660
LEU A 699
 None
 1.06A 4wg0G-4xmvA:
undetectable
4wg0H-4xmvA:
undetectable
4wg0I-4xmvA:
undetectable		 4wg0G-4xmvA:
1.38
4wg0H-4xmvA:
1.38
4wg0I-4xmvA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 GLU A 655
ALA A 658
LEU A 657
TYR A 660
LEU A 699
 None
 1.10A 4wg0K-4xmvA:
undetectable
4wg0L-4xmvA:
undetectable
4wg0M-4xmvA:
undetectable		 4wg0K-4xmvA:
1.38
4wg0L-4xmvA:
1.38
4wg0M-4xmvA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 ALA A 683
LEU A 685
LEU A 619
ARG A 641
LEU A 603
 None
None
None
MLI  A 918 (-4.2A)
None
 1.35A 4xi3A-4xmvA:
undetectable		 4xi3A-4xmvA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 5 ALA A 795
ARG A 840
HIS A 583
ALA A 636
 None
 1.33A 5a06C-4xmvA:
undetectable
5a06D-4xmvA:
undetectable		 5a06C-4xmvA:
18.71
5a06D-4xmvA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		3 / 3 HIS A 301
SER A 233
ASN A 269
 ZN  A 901 ( 3.2A)
None
None
 0.86A 5cprB-4xmvA:
undetectable		 5cprB-4xmvA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 213
ILE A 252
LEU A 268
GLY A 267
ILE A 270
 None
 1.25A 5j7wC-4xmvA:
2.2		 5j7wC-4xmvA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 11 GLN A 724
ASN A 760
THR A 764
TYR A 735
LEU A 717
 None
 1.45A 5jh7D-4xmvA:
undetectable		 5jh7D-4xmvA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 6 GLU A 121
PHE A 375
THR A 377
TYR A 376
 ARG  A 902 (-3.1A)
None
None
ARG  A 902 ( 3.8A)
 1.21A 5lrbA-4xmvA:
undetectable		 5lrbA-4xmvA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 7 ARG A 438
PHE A 436
LEU A 394
SER A 537
 None
 1.06A 5uxcA-4xmvA:
undetectable		 5uxcA-4xmvA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		4 / 6 LEU A 731
TYR A 660
ASP A 712
GLN A 665
 None
None
GOL  A 913 (-3.4A)
None
 1.44A 6djzC-4xmvA:
undetectable		 6djzC-4xmvA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 213
ILE A 252
LEU A 268
GLY A 267
ILE A 270
 None
 1.22A 6qxsD-4xmvA:
undetectable		 6qxsD-4xmvA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 213
ILE A 252
LEU A 268
GLY A 267
ILE A 270
 None
 1.27A 6qyaB-4xmvA:
undetectable		 6qyaB-4xmvA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4xmv AMINOPEPTIDASE N
(Escherichia
coli) 		5 / 12 LEU A 213
ILE A 252
LEU A 268
GLY A 267
ILE A 270
 None
 1.25A 6qyaD-4xmvA:
undetectable		 6qyaD-4xmvA:
18.01