SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 5 HIS A 374
GLU A 400
ALA A 398
SER A 406
 None
NAG  A1004 (-3.9A)
None
None
 1.38A 1errA-4xn3A:
undetectable
1errB-4xn3A:
undetectable		 1errA-4xn3A:
17.17
1errB-4xn3A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 5 TYR A 356
VAL A 345
ILE A 310
MET A 359
 None
 1.40A 1opjA-4xn3A:
undetectable		 1opjA-4xn3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 VAL A 483
ILE A 480
ILE A 467
ILE A 502
VAL A 444
 None
 1.02A 1qhsA-4xn3A:
undetectable		 1qhsA-4xn3A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 VAL A 483
ILE A 480
ILE A 467
ILE A 502
VAL A 444
 None
 0.97A 1qhyA-4xn3A:
undetectable		 1qhyA-4xn3A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		3 / 3 ILE A 299
ASP A 270
PHE A 271
 None
 0.60A 1uwjB-4xn3A:
undetectable		 1uwjB-4xn3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 ILE A 496
ALA A 459
ILE A 420
THR A 503
PHE A 424
 None
 1.02A 2cd2A-4xn3A:
undetectable		 2cd2A-4xn3A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 5 GLU A 227
PRO A 194
ILE A 193
GLY A 228
 None
 0.93A 2qeuA-4xn3A:
undetectable
2qeuC-4xn3A:
undetectable		 2qeuA-4xn3A:
12.65
2qeuC-4xn3A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 7 PRO A 252
SER A 255
GLY A 289
TRP A 314
 None
None
None
NAG  A1004 (-4.6A)
 0.95A 2y7kA-4xn3A:
undetectable		 2y7kA-4xn3A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 TYR A 393
ASP A 339
ASN A 471
GLY A 468
ILE A 426
 NAG  A1006 (-3.4A)
NDG  A1005 (-3.0A)
NDG  A1005 (-3.3A)
GLC  A1007 (-3.2A)
None
 1.47A 3a65A-4xn3A:
undetectable		 3a65A-4xn3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 10 VAL A 485
ILE A 465
ALA A 392
ILE A 420
VAL A 449
 None
 1.04A 3me6A-4xn3A:
undetectable		 3me6A-4xn3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 6 PRO A 528
VAL A 524
THR A 531
THR A 530
 None
 1.09A 3tneA-4xn3A:
undetectable		 3tneA-4xn3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 ARG A 505
GLY A 529
ALA A 474
GLY A 473
ASN A 476
 None
 1.13A 3v3oA-4xn3A:
undetectable		 3v3oA-4xn3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 SER A 629
VAL A 628
ILE A 587
SER A 585
PHE A 616
 None
 1.43A 4c49B-4xn3A:
undetectable		 4c49B-4xn3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		3 / 3 LYS A 599
THR A 571
ILE A 514
 None
 0.80A 4e0fB-4xn3A:
3.1		 4e0fB-4xn3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 6 PRO A 528
TYR A 525
TYR A 522
PHE A 461
 None
 1.02A 4g10A-4xn3A:
undetectable		 4g10A-4xn3A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		6 / 12 ILE A 310
ARG A 327
PHE A 301
ILE A 230
VAL A 286
THR A 342
 None
 1.12A 4kfjB-4xn3A:
undetectable		 4kfjB-4xn3A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 4 HIS A 376
GLU A 400
HIS A 374
LEU A 427
 None
NAG  A1004 (-3.9A)
None
None
 1.47A 4m2rA-4xn3A:
undetectable		 4m2rA-4xn3A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 9 ASP A 561
VAL A 615
ALA A 614
GLY A 556
PHE A 584
 None
 1.20A 4mm5A-4xn3A:
undetectable		 4mm5A-4xn3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 11 ASP A 561
VAL A 615
ALA A 614
GLY A 556
PHE A 584
 None
 1.05A 4mm9A-4xn3A:
undetectable		 4mm9A-4xn3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 9 ASP A 561
VAL A 615
ALA A 614
GLY A 556
PHE A 584
 None
 1.10A 4mmbA-4xn3A:
undetectable		 4mmbA-4xn3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 7 ILE A 230
PHE A 244
LEU A 176
THR A 190
 None
 1.09A 4mmcA-4xn3A:
undetectable		 4mmcA-4xn3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 10 ASP A 561
VAL A 615
ALA A 614
GLY A 556
PHE A 584
 None
 1.18A 4mmdA-4xn3A:
undetectable		 4mmdA-4xn3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 9 ASP A 561
VAL A 615
ALA A 614
GLY A 556
PHE A 584
 None
 1.17A 4mmeB-4xn3A:
undetectable		 4mmeB-4xn3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 ASN A 315
ALA A 287
GLY A 289
ILE A 310
GLY A 285
 NAG  A1004 (-3.1A)
None
None
None
None
 1.25A 4obwA-4xn3A:
undetectable		 4obwA-4xn3A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 11 VAL A 545
LEU A 559
GLY A 548
SER A 577
LEU A 576
 None
 1.11A 4zbqA-4xn3A:
undetectable		 4zbqA-4xn3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		4 / 5 LEU A 588
PHE A 616
ILE A 587
ILE A 600
 None
 1.06A 5dzk4-4xn3A:
undetectable
5dzkg-4xn3A:
undetectable
5dzkm-4xn3A:
undetectable
5dzkn-4xn3A:
1.3		 5dzk4-4xn3A:
5.13
5dzkg-4xn3A:
16.84
5dzkm-4xn3A:
16.08
5dzkn-4xn3A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 ILE A 448
VAL A 449
SER A 489
PHE A 490
VAL A 442
 None
 1.18A 5ergB-4xn3A:
undetectable		 5ergB-4xn3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 ILE A 215
TYR A 204
GLY A 214
HIS A 212
GLN A 281
 None
None
None
RAM  A1001 (-3.7A)
None
 1.16A 5n0xB-4xn3A:
undetectable		 5n0xB-4xn3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		3 / 3 TYR A 344
HIS A 397
MET A 396
 NAG  A1004 (-3.7A)
NDG  A1005 (-3.7A)
None
 1.17A 6af6A-4xn3A:
undetectable		 6af6A-4xn3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 GLY A 285
VAL A 286
THR A 297
GLY A 298
GLY A 265
 None
 1.20A 6brdB-4xn3A:
undetectable		 6brdB-4xn3A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4xn3 TAIL SPIKE PROTEIN
(Salmonella
virus
HK620) 		5 / 12 ASN A 415
ILE A 417
VAL A 385
PHE A 424
PHE A 464
 None
 1.18A 6j21A-4xn3A:
undetectable		 6j21A-4xn3A:
21.74