SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 10 GLY A 458
PHE A 368
SER A 461
LEU A 361
LEU A 294
 None
 1.35A 1a8uA-4xniA:
undetectable		 1a8uA-4xniA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 10 GLY A 458
PHE A 368
SER A 461
LEU A 361
LEU A 294
 None
 1.35A 1a8uB-4xniA:
undetectable		 1a8uB-4xniA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		3 / 3 MET A  66
LEU A  69
SER A  70
 None
 0.63A 1ee2A-4xniA:
undetectable		 1ee2A-4xniA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		3 / 3 MET A 426
LEU A 429
SER A 430
 None
 0.61A 1ee2A-4xniA:
undetectable		 1ee2A-4xniA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 12 ALA A 169
ALA A 168
TRP A 323
LEU A 181
ALA A 178
 None
 1.04A 1fm6U-4xniA:
undetectable		 1fm6U-4xniA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 8 SER A  28
ILE A 155
VAL A  67
SER A 431
 None
 1.09A 1kb9A-4xniA:
undetectable
1kb9C-4xniA:
undetectable
1kb9D-4xniA:
undetectable
1kb9E-4xniA:
undetectable		 1kb9A-4xniA:
20.66
1kb9C-4xniA:
24.03
1kb9D-4xniA:
19.08
1kb9E-4xniA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 12 LEU A 117
LEU A 102
VAL A 101
MET A  60
TYR A  63
 None
 1.31A 1kt4A-4xniA:
undetectable		 1kt4A-4xniA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 11 LEU A 117
LEU A 102
VAL A 101
MET A  60
TYR A  63
 None
 1.30A 1kt7A-4xniA:
undetectable		 1kt7A-4xniA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 7 LEU A  36
LEU A  43
ILE A  51
MET A  60
 None
 1.05A 1n13I-4xniA:
undetectable
1n13L-4xniA:
undetectable		 1n13I-4xniA:
8.61
1n13L-4xniA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 6 GLY A 185
ILE A 184
VAL A 166
SER A 180
 None
None
None
78M  A 505 (-4.3A)
 1.05A 1rs7B-4xniA:
undetectable		 1rs7B-4xniA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 12 LEU A 125
ASN A 128
GLY A 123
GLY A  74
THR A 131
 None
 0.80A 2egvA-4xniA:
undetectable		 2egvA-4xniA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 12 LEU A 125
ASN A 128
GLY A 123
GLY A  74
THR A 131
 None
 0.83A 2egvB-4xniA:
undetectable		 2egvB-4xniA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		3 / 3 VAL A  88
TRP A  90
VAL A  93
 None
78M  A 510 ( 4.2A)
None
 0.95A 2izqA-4xniA:
undetectable
2izqB-4xniA:
undetectable		 2izqA-4xniA:
6.55
2izqB-4xniA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 6 TRP A  24
MET A  23
MET A  20
LEU A 157
 None
 1.22A 2oz7A-4xniA:
undetectable		 2oz7A-4xniA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 7 ALA A 307
THR A 308
ALA A 311
ARG A  53
 None
 0.95A 2ql8A-4xniA:
undetectable
2ql8B-4xniA:
undetectable		 2ql8A-4xniA:
14.56
2ql8B-4xniA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 8 GLU A  25
GLU A  22
SER A  70
ILE A 120
 None
 1.00A 3jz0B-4xniA:
undetectable		 3jz0B-4xniA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 12 GLY A  91
ALA A  87
ASN A 128
ILE A  95
ILE A 118
 None
 0.98A 4ax8A-4xniA:
undetectable		 4ax8A-4xniA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 12 GLY A  91
ALA A  87
ASN A 128
ILE A  95
ILE A 118
 None
 0.99A 4aztA-4xniA:
undetectable		 4aztA-4xniA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 12 GLY A  91
ALA A  87
ASN A 128
ILE A  95
ILE A 118
 None
 1.00A 4azvA-4xniA:
undetectable		 4azvA-4xniA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 8 LEU A 402
PHE A 339
PRO A 351
GLN A 350
 None
 1.17A 4j7uD-4xniA:
undetectable		 4j7uD-4xniA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 12 ILE A 165
ALA A 169
ALA A 168
LEU A 181
ALA A 178
 None
 1.17A 4nqaH-4xniA:
undetectable		 4nqaH-4xniA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 7 ASN A 128
TYR A 194
LEU A 190
PHE A 187
 None
None
None
78M  A 505 ( 3.7A)
 1.23A 4yv5A-4xniA:
undetectable		 4yv5A-4xniA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 5 GLU A  22
THR A  21
THR A 135
HIS A 204
 None
 1.18A 5axaA-4xniA:
undetectable		 5axaA-4xniA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 5 GLU A  22
THR A  21
THR A 135
HIS A 204
 None
 1.17A 5axaC-4xniA:
undetectable		 5axaC-4xniA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GS4_A_F9EA601_0
(DIPEPTIDE AND
TRIPEPTIDE PERMEASE
A)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		6 / 10 TYR A  30
LYS A 126
ASN A 156
ASN A 328
PRO A 329
GLU A 400
 None
 1.01A 6gs4A-4xniA:
38.5		 6gs4A-4xniA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GS4_A_F9EA601_0
(DIPEPTIDE AND
TRIPEPTIDE PERMEASE
A)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 10 TYR A  30
LYS A 126
ASN A 328
PRO A 329
GLU A 299
 None
 1.40A 6gs4A-4xniA:
38.5		 6gs4A-4xniA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GZ9_A_TXCA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		6 / 10 TYR A  30
TYR A  68
ASN A 156
ALA A 159
ASN A 328
PRO A 329
 None
 0.59A 6gz9A-4xniA:
46.0		 6gz9A-4xniA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		5 / 6 ASN A 156
ASN A 328
PRO A 329
ILE A 332
GLU A 400
 None
 0.82A 6h7uA-4xniA:
46.1		 6h7uA-4xniA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 6 VAL A 152
ASN A 156
ILE A 332
GLU A 400
 None
 0.89A 6h7uA-4xniA:
46.1		 6h7uA-4xniA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		6 / 8 TYR A  30
ASN A 156
ASN A 328
PRO A 329
ILE A 332
GLU A 400
 None
 0.79A 6hzpA-4xniA:
46.5		 6hzpA-4xniA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4xni DI-OR TRIPEPTIDE:H+
SYMPORTER
(Streptococcus
thermophilus) 		4 / 8 VAL A 152
ASN A 156
ILE A 332
GLU A 400
 None
 0.96A 6hzpA-4xniA:
46.5		 6hzpA-4xniA:
42.33