SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4xnq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS
(Influenza
A
virus) 		4 / 8 ILE D  87
VAL D 151
ASN D 150
LEU D 108
 None
 0.82A 1dzmA-4xnqD:
undetectable		 1dzmA-4xnqD:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS
(Influenza
A
virus) 		4 / 6 LEU D  61
TRP D  69
LEU D  70
PHE D 118
 None
 1.15A 1ru9H-4xnqD:
undetectable
1ru9L-4xnqD:
undetectable		 1ru9H-4xnqD:
19.92
1ru9L-4xnqD:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS
(Influenza
A
virus) 		4 / 6 LEU D  61
TRP D  69
LEU D  70
PHE D 118
 None
 1.20A 1rukH-4xnqD:
undetectable
1rukL-4xnqD:
undetectable		 1rukH-4xnqD:
19.92
1rukL-4xnqD:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS
(Influenza
A
virus) 		5 / 12 PHE D 102
LEU D 177
LEU D 179
TYR D 105
LEU D  61
 None
 1.29A 4j03A-4xnqD:
undetectable		 4j03A-4xnqD:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS
(Influenza
A
virus) 		4 / 7 TYR D 195
TYR D 161
ALA D 132
ILE D 252
 None
 1.06A 4uymB-4xnqD:
undetectable		 4uymB-4xnqD:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS
(Influenza
A
virus) 		4 / 7 THR D 160
TYR D 161
PRO D 162
THR D 163
 None
 1.22A 5b6iA-4xnqD:
undetectable		 5b6iA-4xnqD:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS
(Influenza
A
virus) 		4 / 6 ASN D 170
THR D 171
ASN D 172
ILE D 121
 None
 1.04A 5uigA-4xnqD:
undetectable		 5uigA-4xnqD:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS
(Influenza
A
virus) 		4 / 5 LEU D 179
PHE D 233
LEU D  71
PHE D 148
 None
 1.23A 5x1fC-4xnqD:
undetectable
5x1fJ-4xnqD:
undetectable		 5x1fC-4xnqD:
19.85
5x1fJ-4xnqD:
15.23